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These studies describe how TIM‑3 and its various ligands (for example, galectin‑9 and HMGB1) orchestrate the termination and modulation of immune responses in diverse contexts such as T helper 1 cell exhaustion, tumor‐infiltrating dendritic cell function, viral infection, autoimmunity, and tissue tolerance in transplantation and pregnancy."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "45"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Christian Stehlik, Maryla Krajewska, Kate Welsh, et al. 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