{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPYGO2 functions as a critical nuclear co‐activator within the canonical Wnt/β–catenin transcription complex. Its highly conserved plant homeodomain (PHD) finger selectively reads methylated histone H3 tails (H3K4me2/3), thereby recruiting multiple epigenetic modifiers – including MLL/MLL2 histone methyltransferase, STAGA/CBP histone acetyltransferase complexes, and other chromatin regulatory factors – to promote histone acetylation and methylation. These coordinated events facilitate the transcription of Wnt target genes, regulate histone gene expression, and even modulate rRNA production, ultimately impacting cell cycle progression and the maintenance of proliferative and stem‐like states in both normal and malignant cells."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a wide range of cancers—including breast, ovarian, glioma, prostate, hepatocellular, and colorectal carcinoma—PYGO2 is frequently overexpressed, where it acts as a potent oncogenic driver. Its elevated expression not only reinforces aberrant Wnt/β–catenin signaling but also promotes the transcription of oncogenes such as MDR1, cyclin D1, and MYC, thereby facilitating cell proliferation, cancer stem cell expansion, invasion, metastasis, and chemoresistance. 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