{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRab11‐family interacting protein 1 (Rab11FIP1), also known as Rab‐coupling protein (RCP), is a multifunctional effector of the Rab11 GTPases that plays a pivotal role in endosomal recycling. Early studies identified Rab11FIP1 as a membrane‐bound protein that interacts with GTP-bound Rab11 (and, more weakly, Rab4), thereby regulating the sorting and recycling of key cargo such as the transferrin receptor. Its molecular function is further modulated by specific structural features – for example, PEST sequences that mediate calcium‐dependent, calpain‐regulated degradation – and by the production of multiple alternatively spliced isoforms that display distinct subcellular localizations. Moreover, Rab11FIP1 participates in directing retrograde transport from early/recycling endosomes to the trans-Golgi network and helps organize a dynamic, spatially compartmentalized recycling network that is sensitive to phosphoinositide signaling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of cancer, Rab11FIP1 is a critical regulator of receptor and integrin recycling—a function that may underpin aggressive tumour behavior. Enhanced recycling of cargo such as α5β1 integrin and receptor tyrosine kinases (including EGFR and EphA2) promotes rapid cell migration, invasion and ultimately metastasis. In breast and other cancers, amplification or overexpression of Rab11FIP1 can activate downstream signaling cascades (involving Ras, ERK/Akt and NF‐κB) and induce epithelial-to-mesenchymal transition. Conversely, its levels can be modulated by mutant p53 or specific microRNAs (for example, miR‐93 and miR‐205) to either augment or suppress these oncogenic processes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its putative role in oncogenesis, Rab11FIP1 orchestrates diverse specialized trafficking events in multiple cell types. In neurons, for instance, Rab11FIP1 regulates the recycling and compartmentalization of integrins to promote axon growth and regeneration. In immune and epithelial cells, it facilitates the incorporation of viral envelope glycoproteins into budding HIV‐1 particles, governs the retrograde targeting of recycling vesicles via tethering proteins such as Golgin-97, and even participates in the recycling of ion channels (like hERG) and GPCRs. Additional roles include modulating receptor internalization—as seen for PAR1 in thrombin signaling—and mediating the late stages of cytokinesis via its recruitment to the midbody, as well as supporting the transcytosis of polymeric immunoglobulin A. Combined, these findings underscore Rab11FIP1’s function as an essential trafficking scaffold that integrates membrane recycling with cell signaling and structural remodeling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "22", "end_ref": "32"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Andrew J Lindsay, Alan G Hendrick, Giuseppina Cantalupo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M108665200"}], "href": "https://doi.org/10.1074/jbc.M108665200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11786538"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11786538"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Andrew A Peden, Eric Schonteich, John Chun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The RCP-Rab11 complex regulates endocytic protein sorting."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e03-12-0918"}], "href": "https://doi.org/10.1091/mbc.e03-12-0918"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15181150"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15181150"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "María T Damiani, Martín Pavarotti, Natalia Leiva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab coupling protein associates with phagosomes and regulates recycling from the phagosomal compartment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Traffic (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1600-0854.2004.00220.x"}], "href": "https://doi.org/10.1111/j.1600-0854.2004.00220.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15355514"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15355514"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Nicolas Marie, Andrew J Lindsay, Mary W McCaffrey "}, {"type": "b", "children": [{"type": "t", "text": "Rab coupling protein is selectively degraded by calpain in a Ca2+-dependent manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20042116"}], "href": "https://doi.org/10.1042/BJ20042116"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15769254"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15769254"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yuki Tajika, Toshiyuki Matsuzaki, Takeshi Suzuki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential regulation of AQP2 trafficking in endosomes by microtubules and actin filaments."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histochem Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00418-005-0010-3"}], "href": "https://doi.org/10.1007/s00418-005-0010-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16049696"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16049696"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "V S Patil, G Sachdeva, D N Modi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab coupling protein (RCP): a novel target of progesterone action in primate endometrium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Endocrinol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1677/jme.1.01807"}], "href": "https://doi.org/10.1677/jme.1.01807"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16216915"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16216915"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Min Jin, James R Goldenring "}, {"type": "b", "children": [{"type": "t", "text": "The Rab11-FIP1/RCP gene codes for multiple protein transcripts related to the plasma membrane recycling system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbaexp.2006.06.001"}], "href": "https://doi.org/10.1016/j.bbaexp.2006.06.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16920206"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16920206"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jian Jing, Jagath R Junutula, Christine Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FIP1/RCP binding to Golgin-97 regulates retrograde transport from recycling endosomes to the trans-Golgi network."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E10-04-0313"}], "href": "https://doi.org/10.1091/mbc.E10-04-0313"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20610657"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20610657"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Martín Pavarotti, Anahí Capmany, Nicolas Vitale, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab11 is phosphorylated by classical and novel protein kinase C isoenzymes upon sustained phorbol ester activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Cell (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/boc.201100062"}], "href": "https://doi.org/10.1111/boc.201100062"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22188018"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22188018"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Nicholas W Baetz, James R Goldenring "}, {"type": "b", "children": [{"type": "t", "text": "Rab11-family interacting proteins define spatially and temporally distinct regions within the dynamic Rab11a-dependent recycling system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E12-09-0659"}], "href": "https://doi.org/10.1091/mbc.E12-09-0659"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23283983"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23283983"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Carlo Cosimo Campa, Emilio Hirsch "}, {"type": "b", "children": [{"type": "t", "text": "Rab11 and phosphoinositides: A synergy of signal transducers in the control of vesicular trafficking."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Adv Biol Regul (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jbior.2016.09.002"}], "href": "https://doi.org/10.1016/j.jbior.2016.09.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27658318"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27658318"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Carlo Cosimo Campa, Jean Piero Margaria, Abhishek Derle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab11 activity and PtdIns(3)P turnover removes recycling cargo from endosomes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Chem Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41589-018-0086-4"}], "href": "https://doi.org/10.1038/s41589-018-0086-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29915378"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29915378"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Patrick T Caswell, May Chan, Andrew J Lindsay, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab-coupling protein coordinates recycling of alpha5beta1 integrin and EGFR1 to promote cell migration in 3D microenvironments."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200804140"}], "href": "https://doi.org/10.1083/jcb.200804140"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18838556"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18838556"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Jinqiu Zhang, Xuejing Liu, Arpita Datta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RCP is a human breast cancer-promoting gene with Ras-activating function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI37622"}], "href": "https://doi.org/10.1172/JCI37622"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19620787"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19620787"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Pierre-Luc Boulay, Louise Mitchell, Jason Turpin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab11-FIP1C Is a Critical Negative Regulator in ErbB2-Mediated Mammary Tumor Progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-15-2782"}], "href": "https://doi.org/10.1158/0008-5472.CAN-15-2782"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26933086"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26933086"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Jing Zhang, Fenfen Wang, Junfen Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Micro ribonucleic acid-93 promotes oncogenesis of cervical cancer by targeting RAB11 family interacting protein 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Obstet Gynaecol Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jog.13027"}], "href": "https://doi.org/10.1111/jog.13027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27279231"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27279231"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "M H Hwang, K H Cho, K J Jeong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RCP induces Slug expression and cancer cell invasion by stabilizing β1 integrin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2016.277"}], "href": "https://doi.org/10.1038/onc.2016.277"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27524413"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27524413"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Christine Gundry, Sergi Marco, Elena Rainero, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms14646"}], "href": "https://doi.org/10.1038/ncomms14646"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28294115"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28294115"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Shaosen Zhang, Caihong Wang, Boyuan Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutant p53 Drives Cancer Metastasis via RCP-Mediated Hsp90α Secretion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2020.107879"}], "href": "https://doi.org/10.1016/j.celrep.2020.107879"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32640214"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32640214"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Jin Young Kim, Kyung Hwa Cho, Bo Young Jeong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Zeb1 for RCP-induced oral cancer cell invasion and its suppression by resveratrol."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Mol Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s12276-020-0474-1"}], "href": "https://doi.org/10.1038/s12276-020-0474-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32728068"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32728068"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Saurav Bhattacharya, Sushmita Sarker, Shaswati Das, et al. "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-205 represses breast cancer metastasis by perturbing the rab coupling protein [RCP]-mediated integrin β1 recycling on the membrane."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Apoptosis (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10495-023-01912-7"}], "href": "https://doi.org/10.1007/s10495-023-01912-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37945815"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37945815"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Richard Eva, Elisa Dassie, Patrick T Caswell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab11 and its effector Rab coupling protein contribute to the trafficking of beta 1 integrins during axon growth in adult dorsal root ganglion neurons and PC12 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.2425-10.2010"}], "href": "https://doi.org/10.1523/JNEUROSCI.2425-10.2010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20810886"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20810886"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Natasha L Grimsey, Catherine E Goodfellow, Mike Dragunow, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cannabinoid receptor 2 undergoes Rab5-mediated internalization and recycles via a Rab11-dependent pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2011.05.010"}], "href": "https://doi.org/10.1016/j.bbamcr.2011.05.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21640764"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21640764"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Mingli Qi, Janice A Williams, Hin Chu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab11-FIP1C and Rab14 direct plasma membrane sorting and particle incorporation of the HIV-1 envelope glycoprotein complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Pathog (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.ppat.1003278"}], "href": "https://doi.org/10.1371/journal.ppat.1003278"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23592992"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23592992"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Marie-Claude Landry, Claudia Champagne, Marie-Chloé Boulanger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A functional interplay between the small GTPase Rab11a and mitochondria-shaping proteins regulates mitochondrial positioning and polarization of the actin cytoskeleton downstream of Src family kinases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.516351"}], "href": "https://doi.org/10.1074/jbc.M113.516351"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24302731"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24302731"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Patrick Lall, Andrew J Lindsay, Sara Hanscom, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure-Function Analyses of the Interactions between Rab11 and Rab14 Small GTPases with Their Shared Effector Rab Coupling Protein (RCP)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.612366"}], "href": "https://doi.org/10.1074/jbc.M114.612366"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26032412"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26032412"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Jeffery Chen, Jun Guo, Tonghua Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab11-dependent Recycling of the Human Ether-a-go-go-related Gene (hERG) Channel."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M115.636324"}], "href": "https://doi.org/10.1074/jbc.M115.636324"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26152716"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26152716"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Jenny C Schafer, Rebecca E McRae, Elizabeth H Manning, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab11-FIP1A regulates early trafficking into the recycling endosomes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2016.01.003"}], "href": "https://doi.org/10.1016/j.yexcr.2016.01.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26790954"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26790954"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Alejandro Alvarez-Arce, Irene Lee-Rivera, Edith López, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Thrombin-activated PAR1 membrane expression is regulated by Rab11a-RCP complex dissociation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2020.109748"}], "href": "https://doi.org/10.1016/j.cellsig.2020.109748"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32860953"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32860953"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Nicholas V G Iannantuono, Gregory Emery "}, {"type": "b", "children": [{"type": "t", "text": "Rab11FIP1 maintains Rab35 at the intercellular bridge to promote actin removal and abscission."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.244384"}], "href": "https://doi.org/10.1242/jcs.244384"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34152390"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34152390"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Xuxu Fan, Dihan Zhou, Bali Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab11-FIP1 and Rab11-FIP5 Regulate pIgR/pIgA Transcytosis through TRIM21-Mediated Polyubiquitination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms221910466"}], "href": "https://doi.org/10.3390/ijms221910466"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34638806"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34638806"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Melissa V Fernandez-de Céspedes, Huxley K Hoffman, Hannah Carter, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab11-FIP1C Is Dispensable for HIV-1 Replication in Primary CD4"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "+"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": " T Cells, but Its Role Is Cell Type Dependent in Immortalized Human T-Cell Lines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/jvi.00876-22"}], "href": "https://doi.org/10.1128/jvi.00876-22"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36354340"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36354340"}]}]}]}