RAB11FIP3 Gene

HGNC Family	EF-hand domain containing
Name	RAB11 family interacting protein 3 (class II)
Description	Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP3 is one of many proteins that interact with and regulate Rab GTPases (Hales et al., 2001 [PubMed 11495908]).[supplied by OMIM, Mar 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRab11-FIP3 is a multifunctional effector protein that primarily interacts with Rab11 and ARF GTPases to regulate membrane trafficking. It localizes to a pericentrosomal endosomal recycling compartment and to distinct vesicular structures throughout the cell. Notably, during cell division, Rab11-FIP3 accumulates at the cleavage furrow and midbody, where it promotes the targeted delivery and fusion of recycling endosomes necessary for the final stages of cytokinesis (abscission). In addition, its coiled‐coil domains mediate homodimerization and support the structural integrity of the recycling compartment."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in cytokinesis, Rab11-FIP3 links membrane trafficking with the microtubule motor machinery. It interacts with dynein light intermediate chains—thereby targeting dynein complexes to endosomal membranes—and is essential for the proper positioning of endocytosed cargo such as transferrin in the pericentrosomal region. Moreover, through its association with ARF6, Rab11-FIP3 facilitates the recruitment of ARF6 to the cleavage furrow, further contributing to efficient membrane remodeling during late telophase."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRab11-FIP3 also plays specialized roles in receptor transport pathways. In polarized cells, it is critical for primary cilia function by orchestrating the endosomal recycling of sensory receptors such as rhodopsin—this involves modulating the interactions among ASAP1, Rab11a, and the Rab8 guanine nucleotide exchange factor Rabin8 during ciliary trafficking. Furthermore, recent studies have identified an IKZF4/NONO–Rab11-FIP3 regulatory axis that enhances the recycling of PD-L1 to the plasma membrane in gastric cancer cells, thereby contributing to tumor immune evasion. These findings highlight the versatility of Rab11-FIP3 in integrating membrane trafficking with diverse cellular functions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Conor P Horgan, Melanie Walsh, Tomas H Zurawski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab11-FIP3 localises to a Rab11-positive pericentrosomal compartment during interphase and to the cleavage furrow during cytokinesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2004.04.157"}], "href": "https://doi.org/10.1016/j.bbrc.2004.04.157"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15158446"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15158446"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Gayle M Wilson, Andrew B Fielding, Glenn C Simon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e04-10-0927"}], "href": "https://doi.org/10.1091/mbc.e04-10-0927"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15601896"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15601896"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Tomoo Shiba, Hiroshi Koga, Hye-Won Shin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0605357103"}], "href": "https://doi.org/10.1073/pnas.0605357103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17030804"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17030804"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Conor P Horgan, Arkadiusz Oleksy, Alexander V Zhdanov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab11-FIP3 is critical for the structural integrity of the endosomal recycling compartment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Traffic (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1600-0854.2007.00543.x"}], "href": "https://doi.org/10.1111/j.1600-0854.2007.00543.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17394487"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17394487"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Eric Schonteich, Manohar Pilli, Glenn C Simon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular characterization of Rab11-FIP3 binding to ARF GTPases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejcb.2007.05.004"}], "href": "https://doi.org/10.1016/j.ejcb.2007.05.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17628206"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17628206"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Conor P Horgan, Sara R Hanscom, Rushee S Jolly, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab11-FIP3 binds dynein light intermediate chain 2 and its overexpression fragments the Golgi complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2010.03.028"}], "href": "https://doi.org/10.1016/j.bbrc.2010.03.028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20214888"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20214888"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jing Wang, Dusanka Deretic "}, {"type": "b", "children": [{"type": "t", "text": "The Arf and Rab11 effector FIP3 acts synergistically with ASAP1 to direct Rabin8 in ciliary receptor targeting."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.162925"}], "href": "https://doi.org/10.1242/jcs.162925"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25673879"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25673879"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Nuoqing Weng, Chuzhou Zhou, Yuhang Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IKZF4/NONO-RAB11FIP3 axis promotes immune evasion in gastric cancer via facilitating PD-L1 endosome recycling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2024.216618"}], "href": "https://doi.org/10.1016/j.canlet.2024.216618"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38211652"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38211652"}]}]}]}
Synonyms	RAB11-FIP3
Proteins	RFIP3_HUMAN
NCBI Gene ID	9727
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RAB11FIP3 has 5,999 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 116 datasets.

Click the + buttons to view associations for RAB11FIP3 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RAB11FIP3 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by RAB11FIP3 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RAB11FIP3 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of RAB11FIP3 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of RAB11FIP3 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of RAB11FIP3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RAB11FIP3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RAB11FIP3 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RAB11FIP3 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RAB11FIP3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RAB11FIP3 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RAB11FIP3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of RAB11FIP3 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with RAB11FIP3 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with RAB11FIP3 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RAB11FIP3 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RAB11FIP3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RAB11FIP3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing RAB11FIP3 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RAB11FIP3 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RAB11FIP3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing RAB11FIP3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing RAB11FIP3 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing RAB11FIP3 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RAB11FIP3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RAB11FIP3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RAB11FIP3 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RAB11FIP3 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with RAB11FIP3 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with RAB11FIP3 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by RAB11FIP3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with RAB11FIP3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RAB11FIP3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RAB11FIP3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RAB11FIP3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RAB11FIP3 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RAB11FIP3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of RAB11FIP3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing RAB11FIP3 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of RAB11FIP3 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with RAB11FIP3 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.