{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRab25 is an epithelial‐specific small GTPase that orchestrates endosomal recycling and vesicular trafficking, thereby directing the delivery of key cargo such as β1‐integrin to discrete plasma membrane domains. By partnering directly with the integrin cytoplasmic tail and effector proteins like Rab Coupling Protein (FIP2), Rab25 modulates cell polarity and promotes dynamic membrane protrusions—processes that underpin pseudopod extension and cell motility. These vesicle‐trafficking functions are essential for establishing the polarized distribution of adhesion receptors that both support normal epithelial organization and, when aberrantly regulated, facilitate invasive cellular behavior."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNotably, Rab25 exhibits a context‐dependent duality in tumorigenesis. In certain epithelial cancers—such as ovarian carcinoma, renal cell carcinoma, hepatocellular carcinoma, and subsets of non‐small cell lung cancer—increased Rab25 expression enhances pro‐survival signaling (via AKT, mTOR, and HIF‐1α pathways), promotes epithelial‐to‐mesenchymal transition (EMT) and supports chemoresistance, thereby acting in a pro‐tumorigenic manner. In contrast, in malignancies of the colon, head and neck and in triple‐negative breast cancer, reduced or absent Rab25 disrupts epithelial polarity and integrin recycling, contributing to tumor progression and metastasis. Thus, Rab25 can function either as an oncogene or as a tumor suppressor depending on the cellular context and tissue type."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "27"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAt the molecular level, Rab25 expression is intricately controlled by epigenetic and transcriptional mechanisms. An open chromatin conformation at its core promoter facilitates CREB binding and recruitment of co-activators, thereby upregulating Rab25 transcription. In addition, dynamic interactions with effector proteins—such as the formation of heterotetrameric complexes with FIP2—finely tune its role in vesicular transport. Epigenetic modifications, including promoter hypermethylation and regulation by transcription factors like ZEB2, further modulate Rab25 levels and, in turn, impact downstream pathways (including EGFR, AKT, HIF‐1α, and Wnt signaling) that govern tumor cell bioenergetics, chemoresistance and sensitivity to therapeutic agents. These integrated regulatory networks underscore Rab25’s multifaceted contributions to tumor biology and its potential as both a prognostic biomarker and a therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "28"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Patrick T Caswell, Heather J Spence, Maddy Parsons, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Cell (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.devcel.2007.08.012"}], "href": "https://doi.org/10.1016/j.devcel.2007.08.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17925226"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17925226"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Daniel Kessler, Gianna-Carina Gruen, Dominik Heider, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The action of small GTPases Rab11 and Rab25 in vesicle trafficking during cell migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000295249"}], "href": "https://doi.org/10.1159/000295249"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22613965"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22613965"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Moorthy Krishnan, Lynne A Lapierre, Byron C Knowles, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab25 regulates integrin expression in polarized colonic epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E12-10-0745"}], "href": "https://doi.org/10.1091/mbc.E12-10-0745"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23345591"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23345591"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jiaxing Zhang, Jinhuan Wei, Jian Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of Rab25 contributes to metastasis of bladder cancer through induction of epithelial-mesenchymal transition and activation of Akt/GSK-3β/Snail signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgt187"}], "href": "https://doi.org/10.1093/carcin/bgt187"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23722651"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23722651"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yang Fan, Xiao-Yan Xin, Bi-Liang Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of RAB25 expression by RNAi inhibits growth of human epithelial ovarian cancer cells in vitro and in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathology (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/00313020601024037"}], "href": "https://doi.org/10.1080/00313020601024037"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17393986"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17393986"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ji-Ming Cheng, Lisa Volk, Deepak Kumar Mummidavarapu Janaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor suppressor function of Rab25 in triple-negative breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.24900"}], "href": "https://doi.org/10.1002/ijc.24900"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19795443"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19795443"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Ki Taek Nam, Hyuk-Joon Lee, J Joshua Smith, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI40728"}], "href": "https://doi.org/10.1172/JCI40728"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20197623"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20197623"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Kwai Wa Cheng, Roshan Agarwal, Shreya Mitra, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab25 increases cellular ATP and glycogen stores protecting cancer cells from bioenergetic stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Mol Med (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/emmm.201100193"}], "href": "https://doi.org/10.1002/emmm.201100193"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22253197"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22253197"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Y X Yin, F Shen, H Pei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased expression of Rab25 in breast cancer correlates with lymphatic metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-012-0412-5"}], "href": "https://doi.org/10.1007/s13277-012-0412-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22644676"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22644676"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Man Tong, Kwok Wah Chan, Jessie Y J Bao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab25 is a tumor suppressor gene with antiangiogenic and anti-invasive activities in esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-12-1269"}], "href": "https://doi.org/10.1158/0008-5472.CAN-12-1269"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22991305"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22991305"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Shreya Mitra, Kwai W Cheng, Gordon B Mills "}, {"type": "b", "children": [{"type": "t", "text": "Rab25 in cancer: a brief update."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Soc Trans (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BST20120249"}], "href": "https://doi.org/10.1042/BST20120249"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23176489"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23176489"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Marta Téllez-Gabriel, Irene Arroyo-Solera, Xavier León, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High RAB25 expression is associated with good clinical outcome in patients with locally advanced head and neck squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.153"}], "href": "https://doi.org/10.1002/cam4.153"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24403269"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24403269"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yuanyuan Li, Qingzhu Jia, Qian Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab25 upregulation correlates with the proliferation, migration, and invasion of renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2015.01.144"}], "href": "https://doi.org/10.1016/j.bbrc.2015.01.144"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25686498"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25686498"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Y F Ma, B Yang, J Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of Ras-related protein 25 predicts chemotherapy resistance and prognosis in advanced non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Mol Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4238/2015.October.29.19"}], "href": "https://doi.org/10.4238/2015.October.29.19"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26535714"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26535714"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Donghua Geng, Wenyan Zhao, Yong Feng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of Rab25 promotes hepatocellular carcinoma cell proliferation and invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-015-4606-5"}], "href": "https://doi.org/10.1007/s13277-015-4606-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26692100"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26692100"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Natividad Gomez-Roman, Neha Mohan Sahasrabudhe, Fiona McGregor, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypoxia-inducible factor 1 alpha is required for the tumourigenic and aggressive phenotype associated with Rab25 expression in ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.7998"}], "href": "https://doi.org/10.18632/oncotarget.7998"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26967059"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26967059"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Shreya Mitra, Lorenzo Federico, Wei Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab25 acts as an oncogene in luminal B breast cancer and is causally associated with Snail driven EMT."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.9730"}], "href": "https://doi.org/10.18632/oncotarget.9730"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27259233"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27259233"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "M J A M Clausen, L J Melchers, M F Mastik, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RAB25 expression is epigenetically downregulated in oral and oropharyngeal squamous cell carcinoma with lymph node metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Epigenetics (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15592294.2016.1205176"}], "href": "https://doi.org/10.1080/15592294.2016.1205176"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27379752"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27379752"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Bingqian Ding, Bei Cui, Ming Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of Ras-Related Protein 25 (Rab25) Inhibits the In Vitro Cytotoxicity and In Vivo Antitumor Activity of Human Glioblastoma Multiforme Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3727/096504016X14736286083065"}], "href": "https://doi.org/10.3727/096504016X14736286083065"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28281975"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28281975"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Zi-Hao Feng, Yong Fang, Liang-Yun Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RIN1 promotes renal cell carcinoma malignancy by activating EGFR signaling through Rab25."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.13297"}], "href": "https://doi.org/10.1111/cas.13297"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28612496"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28612496"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Elizabeth S Taglauer, Patrycja A Artemiuk, Sara R Hanscom, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab11 family expression in the human placenta: Localization at the maternal-fetal interface."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0184864"}], "href": "https://doi.org/10.1371/journal.pone.0184864"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28922401"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28922401"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Yinmin Gu, Yi Ming Zou, Danqing Lei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Promoter DNA methylation analysis reveals a novel diagnostic CpG-based biomarker and RAB25 hypermethylation in clear cell renel cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-017-14314-y"}], "href": "https://doi.org/10.1038/s41598-017-14314-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29079774"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29079774"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Chonggao Yin, Qingjie Mou, Xinting Pan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-577 suppresses epithelial-mesenchymal transition and metastasis of breast cancer by targeting Rab25."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Thorac Cancer (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/1759-7714.12612"}], "href": "https://doi.org/10.1111/1759-7714.12612"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29524309"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29524309"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Jianmin Wang, Pu Zhou, Xudong Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab25 promotes erlotinib resistance by activating the β1 integrin/AKT/β-catenin pathway in NSCLC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Prolif (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cpr.12592"}], "href": "https://doi.org/10.1111/cpr.12592"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30848009"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30848009"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "C-H Hu, X-J Yang, L Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC00173 serves as sponge for miR-338-3p to promote prostate cancer progression via regulating Rab25."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202009_23011"}], "href": "https://doi.org/10.26355/eurrev_202009_23011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33015770"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33015770"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Qiang Zhang, Zhicheng Zhang, Xueyu He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of Rab25 is down-regulated in the foreskin of children with hypospadias."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pediatr Urol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jpurol.2023.05.006"}], "href": "https://doi.org/10.1016/j.jpurol.2023.05.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37246119"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37246119"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Pooja Joshi, Vijayalakshmi Ayyagari, Samikshya Kandel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of RAB25 Cooperates with Oncogenes in the Transformation of Human Mammary Epithelial Cells (HMECs) to Give Rise to Claudin-Low Tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2024/8544837"}], "href": "https://doi.org/10.1155/2024/8544837"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38803515"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38803515"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Huiping Xue, Yongxia Qiao, Peihua Ni, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A CRE that binds CREB and contributes to PKA-dependent regulation of the proximal promoter of human RAB25 gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biochem Cell Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biocel.2010.11.002"}], "href": "https://doi.org/10.1016/j.biocel.2010.11.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21075212"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21075212"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Nicolas Skrypek, Kenneth Bruneel, Cindy Vandewalle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ZEB2 stably represses RAB25 expression through epigenetic regulation by SIRT1 and DNMTs during epithelial-to-mesenchymal transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Epigenetics Chromatin (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13072-018-0239-4"}], "href": "https://doi.org/10.1186/s13072-018-0239-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30445998"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30445998"}]}]}]}