RAB26 Gene

HGNC Family	Ras small GTPases superfamily
Name	RAB26, member RAS oncogene family
Description	Members of the RAB protein family, including RAB26, are important regulators of vesicular fusion and trafficking. The RAB family of small G proteins regulates intercellular vesicle trafficking, including exocytosis, endocytosis, and recycling (summary by Seki et al., 2000 [PubMed 11043516]).[supplied by OMIM, Nov 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRab26 has emerged as a key regulator of vesicle dynamics in neurons by specifically associating with clusters of synaptic vesicles and directing these vesicles into preautophagosomal structures. This activity promotes the selective degradation of aged or dysfunctional vesicles and may be critical for maintaining proper synaptic function. In addition, variations in a GCC repeat within the RAB26 gene have been linked to altered vesicle transport and axonal dystrophy, suggesting a potential connection with late‐onset neurodegenerative disorders such as Alzheimer’s disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn secretory cells, Rab26 is transcriptionally upregulated by key developmental factors to support cell-type–specific architecture remodeling. In gastric chief cells, for example, the transcription factor MIST1 directly activates the expression of RAB26 (along with other small GTPases), thereby establishing large secretory granules essential for proper secretion. In parallel, studies in maturing secretory cells have revealed that heightened Rab26 expression drives a reorganization of lysosomal compartments, prompting lysosome clustering and redistribution of mitochondria; this reorganization may be pivotal for secretory cell maturation and function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in vesicle clustering and secretory granule formation, Rab26 is instrumental in regulating membrane trafficking and cell signaling in various contexts. Rab26 interacts activation-dependently with the third intracellular loop of α2-adrenergic receptors, facilitating their export from the Golgi to the plasma membrane and ensuring efficient receptor-mediated signaling. In the realm of cancer biology, Rab26 has been shown to suppress migratory and invasive behavior in breast cancer cells by fostering the autophagic degradation of phosphorylated Src, while in non-small cell lung cancer its transcriptional activation by SMAD3 underpins tumor progression. Moreover, in airway epithelial cells, Rab26 expression is downregulated by cigarette smoke-induced oxidative stress through promoter hypermethylation, with restoration of its levels attenuating inflammatory responses via partial inactivation of p38 and JNK MAPK signaling pathways."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Beyenech Binotti, Nathan J Pavlos, Dietmar Riedel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The GTPase Rab26 links synaptic vesicles to the autophagy pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.05597"}], "href": "https://doi.org/10.7554/eLife.05597"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25643395"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25643395"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "S Alizadeh, S Khamse, N Tajeddin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A GCC repeat in RAB26 undergoes natural selection in human and harbors divergent genotypes in late-onset Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2023.147968"}], "href": "https://doi.org/10.1016/j.gene.2023.147968"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37931854"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37931854"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiaolin Tian, Ramon U Jin, Andrew J Bredemeyer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RAB26 and RAB3D are direct transcriptional targets of MIST1 that regulate exocrine granule maturation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01328-09"}], "href": "https://doi.org/10.1128/MCB.01328-09"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20038531"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20038531"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ramon U Jin, Jason C Mills "}, {"type": "b", "children": [{"type": "t", "text": "RAB26 coordinates lysosome traffic and mitochondrial localization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.138776"}], "href": "https://doi.org/10.1242/jcs.138776"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24413166"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24413166"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Chunman Li, Yi Fan, Tien-Hung Lan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab26 modulates the cell surface transport of α2-adrenergic receptors from the Golgi."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.410936"}], "href": "https://doi.org/10.1074/jbc.M112.410936"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23105096"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23105096"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Huiying Liu, Yuxia Zhou, Hantian Qiu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab26 suppresses migration and invasion of breast cancer cells through mediating autophagic degradation of phosphorylated Src."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-03561-7"}], "href": "https://doi.org/10.1038/s41419-021-03561-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33731709"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33731709"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Haixia Ren, Bo Yang, Mingjiang Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RAB26 contributes to the progression of non-small cell lung cancer after being transcriptionally activated by SMAD3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2051853"}], "href": "https://doi.org/10.1080/21655979.2022.2051853"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35291909"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35291909"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Bin-Feng He, Yi-Xing Wu, Wei-Ping Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ROS induced the Rab26 promoter hypermethylation to promote cigarette smoking-induced airway epithelial inflammation of COPD through activation of MAPK signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Free Radic Biol Med (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.freeradbiomed.2023.01.001"}], "href": "https://doi.org/10.1016/j.freeradbiomed.2023.01.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36610560"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36610560"}]}]}]}
Synonyms	V46133
Proteins	RAB26_HUMAN
NCBI Gene ID	25837
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RAB26 has 5,243 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 109 datasets.

Click the + buttons to view associations for RAB26 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RAB26 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RAB26 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of RAB26 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of RAB26 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of RAB26 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RAB26 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RAB26 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RAB26 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RAB26 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RAB26 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of RAB26 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RAB26 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of RAB26 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RAB26 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RAB26 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RAB26 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RAB26 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RAB26 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing RAB26 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing RAB26 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RAB26 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RAB26 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RAB26 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RAB26 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with RAB26 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with RAB26 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of RAB26 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by RAB26 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with RAB26 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RAB26 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RAB26 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RAB26 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RAB26 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RAB26 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RAB26 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of RAB26 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing RAB26 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD High Level Gene-Disease Associations	diseases associated with RAB26 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of RAB26 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with RAB26 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing RAB26 from the GeneSigDB Published Gene Signatures dataset.