RAB4A Gene

HGNC Family	Ras small GTPases superfamily
Name	RAB4A, member RAS oncogene family
Description	This gene is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane trafficking. The encoded protein is associated with early endosomes and is involved in their sorting and recycling. The protein also plays a role in regulating the recycling of receptors from endosomes to the plasma membrane. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRab4A is a pivotal regulator of receptor recycling that intricately modulates membrane protein composition in immune cells. In autoimmune settings such as systemic lupus erythematosus, enhanced mTOR activity drives overexpression of HRES‐1/Rab4, which promotes the lysosomal degradation of key T cell surface receptors including TCRζ and CD4, thereby impairing normal T cell signaling. In addition, the original identification of HRES‐1/Rab4 revealed its ability to interact directly with CD4 and other receptors—a process further exploited by viral proteins (for example, HIV‐1 tat) to disrupt receptor recycling—and Rab4A also participates in the trafficking of G protein–coupled receptors such as the oxytocin receptor, underscoring its immunomodulatory potential."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond the immune system, Rab4A orchestrates the rapid recycling of a broad spectrum of receptors and channels. It directs the sorting of recycling receptors such as FcRn in endothelial cells as well as the epithelial sodium channel (ENaC) in secretory epithelia, thereby influencing ion transport and cellular homeostasis. In addition, Rab4A‐dependent trafficking governs the fast recycling “short cycle” of various G protein–coupled receptors—including the beta‑2 adrenergic receptor and the angiotensin II type 1 receptor—as well as integrin αvβ3 recycling that is essential for VEGFR1‐mediated angiogenic processes. Moreover, interactions with adaptor proteins such as D‑AKAP2, and its involvement in the recycling of the prostaglandin D2 receptor (DP1) via enhanced guanine nucleotide exchange, further underscore its role as a master coordinator of endocytic recycling, ensuring proper receptor resensitization and signaling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRab4A’s regulatory reach extends into cancer biology and cellular homeostasis, where its ability to control the recycling dynamics of membrane proteins plays a decisive role in disease progression. In tumor cells, altered Rab4A activity contributes to multidrug resistance by modulating the cell surface expression of P‑glycoprotein and of cardiac ion channels such as hERG via the up‐regulation of specific ubiquitin ligases. Structural studies reveal unique features of the Rab4A nucleotide‐binding pocket that may underlie its specialized recycling kinetics. In melanoma and other cancers, Rab4A regulates epithelial‑to‑mesenchymal transition through activation of RAC1, while its modulation by proteins like TBC1D16 promotes changes in transferrin receptor trafficking and epidermal growth factor receptor degradation. Furthermore, defects in Rab4A‐dependent trafficking are implicated in aberrant endosomal morphology and prolonged receptor signaling in breast cancer, and disruptions in Rab4A–associated recycling through mutated LRBA highlight its importance in immune dysregulation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Andrew J Lindsay, Alan G Hendrick, Giuseppina Cantalupo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M108665200"}], "href": "https://doi.org/10.1074/jbc.M108665200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11786538"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11786538"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Gyorgy Nagy, Jeffrey Ward, Dick D Mosser, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of CD4 expression via recycling by HRES-1/RAB4 controls susceptibility to HIV infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M606301200"}], "href": "https://doi.org/10.1074/jbc.M606301200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16935861"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16935861"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Francesca Conti, Sarah Sertic, Alessandra Reversi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Intracellular trafficking of the human oxytocin receptor: evidence of receptor recycling via a Rab4/Rab5 \"short cycle\"."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Endocrinol Metab (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpendo.90590.2008"}], "href": "https://doi.org/10.1152/ajpendo.90590.2008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19126785"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19126785"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "David R Fernandez, Tiffany Telarico, Eduardo Bonilla, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of mammalian target of rapamycin controls the loss of TCRzeta in lupus T cells through HRES-1/Rab4-regulated lysosomal degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.0803600"}], "href": "https://doi.org/10.4049/jimmunol.0803600"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19201859"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19201859"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "E Sally Ward, Cruz Martinez, Carlos Vaccaro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "From sorting endosomes to exocytosis: association of Rab4 and Rab11 GTPases with the Fc receptor, FcRn, during recycling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e04-08-0735"}], "href": "https://doi.org/10.1091/mbc.e04-08-0735"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15689494"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15689494"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Sunil K Saxena, Madhurima Singh, Hiroshi Shibata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab4 GTP/GDP modulates amiloride-sensitive sodium channel (ENaC) function in colonic epithelia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2005.12.036"}], "href": "https://doi.org/10.1016/j.bbrc.2005.12.036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16389071"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16389071"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Matthew C Jones, Patrick T Caswell, Kim Moran-Jones, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VEGFR1 (Flt1) regulates Rab4 recycling to control fibronectin polymerization and endothelial vessel branching."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Traffic (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1600-0854.2009.00898.x"}], "href": "https://doi.org/10.1111/j.1600-0854.2009.00898.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19302266"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19302266"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Guillermo A Yudowski, Manojkumar A Puthenveedu, Anastasia G Henry, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cargo-mediated regulation of a rapid Rab4-dependent recycling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e08-08-0892"}], "href": "https://doi.org/10.1091/mbc.e08-08-0892"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19369423"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19369423"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Christopher T Eggers, Jenny C Schafer, James R Goldenring, et al. "}, {"type": "b", "children": [{"type": "t", "text": "D-AKAP2 interacts with Rab4 and Rab11 through its RGS domains and regulates transferrin receptor recycling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.022582"}], "href": "https://doi.org/10.1074/jbc.M109.022582"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19797056"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19797056"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jessica L Esseltine, Lianne B Dale, Stephen S G Ferguson "}, {"type": "b", "children": [{"type": "t", "text": "Rab GTPases bind at a common site within the angiotensin II type I receptor carboxyl-terminal tail: evidence that Rab4 regulates receptor phosphorylation, desensitization, and resensitization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Pharmacol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/mol.110.068379"}], "href": "https://doi.org/10.1124/mol.110.068379"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20943774"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20943774"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Chantal Binda, Samuel Génier, Jade Degrandmaison, et al. "}, {"type": "b", "children": [{"type": "t", "text": "L-type prostaglandin D synthase regulates the trafficking of the PGD"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "2"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": " DP1 receptor by interacting with the GTPase Rab4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA119.008233"}], "href": "https://doi.org/10.1074/jbc.RA119.008233"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31575663"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31575663"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Clotilde Ferrándiz-Huertas, Asia Fernández-Carvajal, Antonio Ferrer-Montiel "}, {"type": "b", "children": [{"type": "t", "text": "Rab4 interacts with the human P-glycoprotein and modulates its surface expression in multidrug resistant K562 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.25310"}], "href": "https://doi.org/10.1002/ijc.25310"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20209493"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20209493"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Alice Barbarin, Raymond Frade "}, {"type": "b", "children": [{"type": "t", "text": "Procathepsin L secretion, which triggers tumour progression, is regulated by Rab4a in human melanoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20110361"}], "href": "https://doi.org/10.1042/BJ20110361"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21501115"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21501115"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Zhi Cui, Shetuan Zhang "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of the human ether-a-go-go-related gene (hERG) channel by Rab4 protein through neural precursor cell-expressed developmentally down-regulated protein 4-2 (Nedd4-2)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.461715"}], "href": "https://doi.org/10.1074/jbc.M113.461715"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23792956"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23792956"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Basem S Goueli, Marianne Broome Powell, Elizabeth C Finger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TBC1D16 is a Rab4A GTPase activating protein that regulates receptor recycling and EGF receptor signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1204540109"}], "href": "https://doi.org/10.1073/pnas.1204540109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23019362"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23019362"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Gergely Talaber, Gabriella Miklossy, Zachary Oaks, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HRES-1/Rab4 promotes the formation of LC3(+) autophagosomes and the accumulation of mitochondria during autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0084392"}], "href": "https://doi.org/10.1371/journal.pone.0084392"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24404161"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24404161"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Simone Kälin, David T Hirschmann, Dominik P Buser, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rabaptin5 is recruited to endosomes by Rab4 and Rabex5 to regulate endosome maturation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.174664"}], "href": "https://doi.org/10.1242/jcs.174664"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26430212"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26430212"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Subbulakshmi Karthikeyan, Patrick J Casey, Mei Wang "}, {"type": "b", "children": [{"type": "t", "text": "RAB4A GTPase regulates epithelial-to-mesenchymal transition by modulating RAC1 activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13058-022-01564-6"}], "href": "https://doi.org/10.1186/s13058-022-01564-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36307864"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36307864"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Naava Naslavsky, Steve Caplan "}, {"type": "b", "children": [{"type": "t", "text": "Receptor-mediated internalization promotes increased endosome size and number in a RAB4- and RAB5-dependent manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Cell Biol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejcb.2023.151339"}], "href": "https://doi.org/10.1016/j.ejcb.2023.151339"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37423034"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37423034"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Rui Su, Meng Su, Yan Lu "}, {"type": "b", "children": [{"type": "t", "text": "Ras-related Protein in Brain 4A (Rab4A) is Downregulated by miR-496 to inhibit the Progression of Gastric Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Comb Chem High Throughput Screen (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/0113862073260841231010055245"}], "href": "https://doi.org/10.2174/0113862073260841231010055245"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38523522"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38523522"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Viktória Szentgyörgyi, Leon Maximilian Lueck, Daan Overwijn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Arf1-dependent LRBA recruitment to Rab4 endosomes is required for endolysosome homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.202401167"}], "href": "https://doi.org/10.1083/jcb.202401167"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39325073"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39325073"}]}]}]}
Synonyms	HRES-1/RAB4, HRES1, RAB4
Proteins	RAB4A_HUMAN
NCBI Gene ID	5867
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RAB4A has 7,527 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 120 datasets.

Click the + buttons to view associations for RAB4A from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RAB4A Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RAB4A gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of RAB4A gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of RAB4A gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of RAB4A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RAB4A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RAB4A gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RAB4A gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RAB4A gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RAB4A gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RAB4A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of RAB4A gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with RAB4A protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with RAB4A gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RAB4A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RAB4A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RAB4A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RAB4A gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RAB4A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing RAB4A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RAB4A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RAB4A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RAB4A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RAB4A gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with RAB4A gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with RAB4A gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with RAB4A gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of RAB4A protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by RAB4A gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RAB4A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RAB4A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RAB4A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RAB4A gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RAB4A gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of RAB4A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing RAB4A from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of RAB4A gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with RAB4A gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing RAB4A from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of RAB4A gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of RAB4A gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.