{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRab5A functions as a master regulator of early endocytic trafficking, orchestrating the internalization and sorting of a wide spectrum of receptors and cargo. It governs the formation and homotypic fusion of early endosomes, and by engaging a variety of effector proteins—including APPL1, Rabankyrin‐5, EEA1 and SARA—Rab5A organizes discrete signaling platforms that not only direct clathrin‐mediated endocytosis but also coordinate downstream mitogenic and signal‐transduction cascades. Structural and functional studies have revealed that Rab5A’s GTP‐bound state induces critical conformational changes in tethering proteins to promote endosome fusion, and that its precise cycling is essential for regulating receptor recycling and progression toward later endocytic compartments."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its canonical roles in endocytosis, Rab5A is centrally implicated in diverse pathological contexts. In infectious diseases, Rab5A activity is co‐opted by viruses such as dengue, West Nile, hepatitis C and B, as well as by intracellular bacteria (e.g. Salmonella, Yersinia, group B coxsackievirus and Streptococcus), to facilitate their entry, replication or evasion of host defenses by modulating endosomal maturation, macropinocytosis and vesicular trafficking. Dysregulation of Rab5A is also a common feature in neurodegenerative disorders such as Alzheimer’s disease and Down syndrome, where its overactivation accelerates amyloidogenic processing and neuronal apoptosis. Moreover, in numerous cancers including breast, ovarian, hepatocellular carcinoma and glioma, elevated Rab5A expression—often driven by upstream signals such as Caveolin-1 or altered microRNA activity—promotes abnormal receptor recycling, focal adhesion disassembly and integrin signaling, thereby enhancing cell migration, invasion and metastasis. These findings underscore Rab5A’s pivotal role as a signaling hub that integrates extracellular cues with intracellular trafficking events."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "46"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in membrane trafficking and receptor recycling, Rab5A intersects with cellular quality‐control and metabolic programs. Under conditions of nutrient withdrawal or mitochondrial stress, Rab5A engages with signaling partners including class III phosphatidylinositol 3-kinase complexes and endoplasmic reticulum proteins to promote autophagosomal and mitophagic pathways. This function is integrated into broader Rab cascades that govern endolysosomal maturation and ensure cellular homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "47", "end_ref": "50"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Marta Miaczynska, Savvas Christoforidis, Angelika Giner, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "The Rab5 effector Rabankyrin-5 regulates and coordinates different endocytic mechanisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pbio.0020261"}], "href": "https://doi.org/10.1371/journal.pbio.0020261"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15328530"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15328530"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Owen J Driskell, Aleksandr Mironov, Victoria J Allan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dynein is required for receptor sorting and the morphogenesis of early endosomes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1525"}], "href": "https://doi.org/10.1038/ncb1525"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17173037"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17173037"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Guangyu Zhu, Jia Chen, Jay Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.emboj.7601771"}], "href": "https://doi.org/10.1038/sj.emboj.7601771"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17581628"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17581628"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "David H Murray, Marcus Jahnel, Janelle Lauer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An endosomal tether undergoes an entropic collapse to bring vesicles together."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature19326"}], "href": "https://doi.org/10.1038/nature19326"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27556945"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27556945"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Catherine Sem Wegner, Lene Malerød, Nina Marie Pedersen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ultrastructural characterization of giant endosomes induced by GTPase-deficient Rab5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histochem Cell Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00418-009-0643-8"}], "href": "https://doi.org/10.1007/s00418-009-0643-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19830447"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19830447"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yang Hu, Jen-Zen Chuang, Kai Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SARA, a FYVE domain protein, affects Rab5-mediated endocytosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.00177"}], "href": "https://doi.org/10.1242/jcs.00177"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12432064"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12432064"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "J L Rosenfeld, R H Moore, K P Zimmer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lysosome proteins are redistributed during expression of a GTP-hydrolysis-defective rab5a."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.114.24.4499"}], "href": "https://doi.org/10.1242/jcs.114.24.4499"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11792815"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11792815"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jennifer L Dinneen, Brian P Ceresa "}, {"type": "b", "children": [{"type": "t", "text": "Expression of dominant negative rab5 in HeLa cells regulates endocytic trafficking distal from the plasma membrane."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2003.12.006"}], "href": "https://doi.org/10.1016/j.yexcr.2003.12.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15023538"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15023538"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Huaiping Zhu, Zhimin Liang, Guangpu Li "}, {"type": "b", "children": [{"type": "t", "text": "Rabex-5 is a Rab22 effector and mediates a Rab22-Rab5 signaling cascade in endocytosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e09-06-0453"}], "href": "https://doi.org/10.1091/mbc.e09-06-0453"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19759177"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19759177"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "S Kim, Y Sato, P S Mohan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Psychiatry (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/mp.2015.97"}], "href": "https://doi.org/10.1038/mp.2015.97"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26194181"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26194181"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Olivera M Grbovic, Paul M Mathews, Ying Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M304122200"}], "href": "https://doi.org/10.1074/jbc.M304122200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12761223"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12761223"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Carolyn B Coyne, Le Shen, Jerrold R Turner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Coxsackievirus entry across epithelial tight junctions requires occludin and the small GTPases Rab34 and Rab5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Host Microbe (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.chom.2007.07.003"}], "href": "https://doi.org/10.1016/j.chom.2007.07.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18005733"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18005733"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Manoj N Krishnan, Bindu Sukumaran, Utpal Pal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab 5 is required for the cellular entry of dengue and West Nile viruses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.02210-06"}], "href": "https://doi.org/10.1128/JVI.02210-06"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17301152"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17301152"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Gustavo V Mallo, Marianela Espina, Adam C Smith, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SopB promotes phosphatidylinositol 3-phosphate formation on Salmonella vacuoles by recruiting Rab5 and Vps34."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200804131"}], "href": "https://doi.org/10.1083/jcb.200804131"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18725540"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18725540"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Wen-Chi Su, Ti-Chun Chao, Yih-Leh Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab5 and class III phosphoinositide 3-kinase Vps34 are involved in hepatitis C virus NS4B-induced autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.00173-11"}], "href": "https://doi.org/10.1128/JVI.00173-11"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21835792"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21835792"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Li Li, Eunjung Kim, Haixin Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of mTORC1 by the Rab and Arf GTPases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.C110.102483"}], "href": "https://doi.org/10.1074/jbc.C110.102483"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20457610"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20457610"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Emanuela Frittoli, Andrea Palamidessi, Paola Marighetti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A RAB5/RAB4 recycling circuitry induces a proteolytic invasive program and promotes tumor dissemination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201403127"}], "href": "https://doi.org/10.1083/jcb.201403127"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25049275"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25049275"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Stephen D Ginsberg, Elliott J Mufson, Scott E Counts, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regional selectivity of rab5 and rab7 protein upregulation in mild cognitive impairment and Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Alzheimers Dis (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/JAD-2010-101080"}], "href": "https://doi.org/10.3233/JAD-2010-101080"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20847427"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20847427"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Stephen D Ginsberg, Elliott J Mufson, Melissa J Alldred, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of select rab GTPases in cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Chem Neuroanat (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jchemneu.2011.05.012"}], "href": "https://doi.org/10.1016/j.jchemneu.2011.05.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21669283"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21669283"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Michelle Stone, Shuaizheng Jia, Won Do Heo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Participation of rab5, an early endosome protein, in hepatitis C virus RNA replication machinery."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.01366-06"}], "href": "https://doi.org/10.1128/JVI.01366-06"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17301141"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17301141"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Alina Macovei, Catalina Petrareanu, Catalin Lazar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of hepatitis B virus infection by Rab5, Rab7, and the endolysosomal compartment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.00393-13"}], "href": "https://doi.org/10.1128/JVI.00393-13"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23536683"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23536683"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Yingying Lu, Shichen Dong, Baixia Hao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vacuolin-1 potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/auto.32200"}], "href": "https://doi.org/10.4161/auto.32200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25483964"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25483964"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Francesca Conti, Sarah Sertic, Alessandra Reversi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Intracellular trafficking of the human oxytocin receptor: evidence of receptor recycling via a Rab4/Rab5 \"short cycle\"."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Endocrinol Metab (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpendo.90590.2008"}], "href": "https://doi.org/10.1152/ajpendo.90590.2008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19126785"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19126785"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Pin-I Chen, Chen Kong, Xiong Su, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab5 isoforms differentially regulate the trafficking and degradation of epidermal growth factor receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.034546"}], "href": "https://doi.org/10.1074/jbc.M109.034546"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19723633"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19723633"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Zhenqiang Fu, Wenzheng Luo, Jingtao Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Malat1 activates autophagy and promotes cell proliferation by sponging miR-101 and upregulating STMN1, RAB5A and ATG4D expression in glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2017.08.070"}], "href": "https://doi.org/10.1016/j.bbrc.2017.08.070"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28834690"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28834690"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Christiane Wiesner, Karim El Azzouzi, Stefan Linder "}, {"type": "b", "children": [{"type": "t", "text": "A specific subset of RabGTPases controls cell surface exposure of MT1-MMP, extracellular matrix degradation and three-dimensional invasion of macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.122358"}], "href": "https://doi.org/10.1242/jcs.122358"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23606746"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23606746"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Jing-Fang Wang, Kuo-Chen Chou "}, {"type": "b", "children": [{"type": "t", "text": "Insight into the molecular switch mechanism of human Rab5a from molecular dynamics simulations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2009.10.014"}], "href": "https://doi.org/10.1016/j.bbrc.2009.10.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19819222"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19819222"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Jorge Díaz, Pablo Mendoza, Rina Ortiz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab5 is required in metastatic cancer cells for Caveolin-1-enhanced Rac1 activation, migration and invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.141689"}], "href": "https://doi.org/10.1242/jcs.141689"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24659799"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24659799"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Pablo Mendoza, Rina Ortiz, Jorge Díaz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab5 activation promotes focal adhesion disassembly, migration and invasiveness in tumor cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.119727"}], "href": "https://doi.org/10.1242/jcs.119727"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23813952"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23813952"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Karine Croizet-Berger, Chantal Daumerie, Marianne Couvreur, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The endocytic catalysts, Rab5a and Rab7, are tandem regulators of thyroid hormone production."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.122187699"}], "href": "https://doi.org/10.1073/pnas.122187699"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12034881"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12034881"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Natasha L Grimsey, Catherine E Goodfellow, Mike Dragunow, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cannabinoid receptor 2 undergoes Rab5-mediated internalization and recycles via a Rab11-dependent pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2011.05.010"}], "href": "https://doi.org/10.1016/j.bbamcr.2011.05.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21640764"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21640764"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Vicente A Torres, Ainhoa Mielgo, Simone Barbero, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab5 mediates caspase-8-promoted cell motility and metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e09-09-0769"}], "href": "https://doi.org/10.1091/mbc.e09-09-0769"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19923319"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19923319"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Helen M Jopling, Adam F Odell, Nigel M Hooper, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab GTPase regulation of VEGFR2 trafficking and signaling in endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/ATVBAHA.109.186239"}], "href": "https://doi.org/10.1161/ATVBAHA.109.186239"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19372461"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19372461"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "FoSheng Hsu, Stephanie Spannl, Charles Ferguson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab5 and Alsin regulate stress-activated cytoprotective signaling on mitochondria."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.32282"}], "href": "https://doi.org/10.7554/eLife.32282"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29469808"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29469808"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Mandi M Murph, Launa A Scaccia, Laura A Volpicelli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Agonist-induced endocytosis of lysophosphatidic acid-coupled LPA1/EDG-2 receptors via a dynamin2- and Rab5-dependent pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.00397"}], "href": "https://doi.org/10.1242/jcs.00397"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12668728"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12668728"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Atsuo Sakurai, Fumito Maruyama, Junko Funao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Specific behavior of intracellular Streptococcus pyogenes that has undergone autophagic degradation is associated with bacterial streptolysin O and host small G proteins Rab5 and Rab7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.100131"}], "href": "https://doi.org/10.1074/jbc.M109.100131"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20472552"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20472552"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Dan Jane-wit, Yulia V Surovtseva, Lingfeng Qin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Complement membrane attack complexes activate noncanonical NF-κB by forming an Akt+ NIK+ signalosome on Rab5+ endosomes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1503535112"}], "href": "https://doi.org/10.1073/pnas.1503535112"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26195760"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26195760"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Kazutaka Hayashida, Philip D Stahl, Pyong Woo Park "}, {"type": "b", "children": [{"type": "t", "text": "Syndecan-1 ectodomain shedding is regulated by the small GTPase Rab5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M804172200"}], "href": "https://doi.org/10.1074/jbc.M804172200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18957427"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18957427"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "Daphna Laifenfeld, Lucas J Patzek, Donna L McPhie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab5 mediates an amyloid precursor protein signaling pathway that leads to apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.4599-06.2007"}], "href": "https://doi.org/10.1523/JNEUROSCI.4599-06.2007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17611268"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17611268"}]}, {"type": "r", "ref": 41, "children": [{"type": "t", "text": "Po-Sheng Yang, Pen-Hui Yin, Ling-Ming Tseng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab5A is associated with axillary lymph node metastasis in breast cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1349-7006.2011.02089.x"}], "href": "https://doi.org/10.1111/j.1349-7006.2011.02089.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21895870"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21895870"}]}, {"type": "r", "ref": 42, "children": [{"type": "t", "text": "Helen Sarantis, Daniel M Balkin, Pietro De Camilli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Yersinia entry into host cells requires Rab5-dependent dephosphorylation of PI(4,5)P₂ and membrane scission."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Host Microbe (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.chom.2012.01.010"}], "href": "https://doi.org/10.1016/j.chom.2012.01.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22341461"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22341461"}]}, {"type": "r", "ref": 43, "children": [{"type": "t", "text": "Dave Bridges, Kaleigh Fisher, Sergey N Zolov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab5 proteins regulate activation and localization of target of rapamycin complex 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.334060"}], "href": "https://doi.org/10.1074/jbc.M111.334060"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22547071"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22547071"}]}, {"type": "r", "ref": 44, "children": [{"type": "t", "text": "Zhen Zhao, Xiang-Fan Liu, Hua-Cheng Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab5a overexpression promoting ovarian cancer cell proliferation may be associated with APPL1-related epidermal growth factor signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1349-7006.2010.01558.x"}], "href": "https://doi.org/10.1111/j.1349-7006.2010.01558.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20412119"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20412119"}]}, {"type": "r", "ref": 45, "children": [{"type": "t", "text": "Yanrui Sheng, Jianbo Li, Chengcheng Zou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of miR-101-3p by hepatitis B virus promotes proliferation and migration of hepatocellular carcinoma cells by targeting Rab5a."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Virol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00705-014-2084-5"}], "href": "https://doi.org/10.1007/s00705-014-2084-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24788845"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24788845"}]}, {"type": "r", "ref": 46, "children": [{"type": "t", "text": "Nasrin Perskvist, Karin Roberg, Agné Kulyté, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rab5a GTPase regulates fusion between pathogen-containing phagosomes and cytoplasmic organelles in human neutrophils."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.115.6.1321"}], "href": "https://doi.org/10.1242/jcs.115.6.1321"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11884531"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11884531"}]}, {"type": "r", "ref": 47, "children": [{"type": "t", "text": "Zhixun Dou, Ji-An Pan, Hashem A Dbouk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Class IA PI3K p110β subunit promotes autophagy through Rab5 small GTPase in response to growth factor limitation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2013.01.022"}], "href": "https://doi.org/10.1016/j.molcel.2013.01.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23434372"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23434372"}]}, {"type": "r", "ref": 48, "children": [{"type": "t", "text": "Koji Yamano, Chunxin Wang, Shireen A Sarraf, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endosomal Rab cycles regulate Parkin-mediated mitophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.31326"}], "href": "https://doi.org/10.7554/eLife.31326"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29360040"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29360040"}]}, {"type": "r", "ref": 49, "children": [{"type": "t", "text": "Ann-Christin Borchers, Lars Langemeyer, Christian Ungermann "}, {"type": "b", "children": [{"type": "t", "text": "Who's in control? Principles of Rab GTPase activation in endolysosomal membrane trafficking and beyond."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.202105120"}], "href": "https://doi.org/10.1083/jcb.202105120"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34383013"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34383013"}]}, {"type": "r", "ref": 50, "children": [{"type": "t", "text": "Yanjun Li, Yuanbo Zhao, Jia Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel ER-localized transmembrane protein, EMC6, interacts with RAB5A and regulates cell autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/auto.22742"}], "href": "https://doi.org/10.4161/auto.22742"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23182941"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23182941"}]}]}]}