RABGAP1 Gene

Name	RAB GTPase activating protein 1
Description	Enables GTPase activator activity and small GTPase binding activity. Located in cytosol. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies indicate that TP53INP2 plays diverse, tissue‐specific roles by regulating autophagy and signaling pathways. In skeletal muscle, TP53INP2 is a key autophagy activator: its elevated expression stimulates p62‐independent degradation of ubiquitinated proteins, leading to muscle atrophy, whereas its loss promotes hypertrophy. In diabetic conditions—where TP53INP2 is markedly repressed—this regulation may serve as an adaptive mechanism to preserve muscle mass under insulin-deficient states."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the adipose lineage, TP53INP2 functions as a negative regulator of adipogenesis. It achieves this by driving autophagy‐dependent sequestration of GSK3β into late endosomes, resulting in increased β-catenin levels and subsequent activation of TCF/LEF transcription factors, which in turn suppress the expression of master adipogenic genes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nInterestingly, TP53INP2 also exerts a coding-independent role in the nervous system. In sympathetic neurons its transcript acts as a scaffold that interacts with the nerve growth factor (NGF) receptor TrkA, thereby facilitating receptor endocytosis and sustaining NGF-TrkA signaling essential for axon growth. This non-canonical function underscores the emerging concept that mRNAs can influence cellular processes without being translated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nComplementing these findings, investigations into related regulators have highlighted the activity of the EPI64 subfamily, which includes proteins that, in addition to their GAP activity towards select Rab GTPases (e.g., Rab35), exhibit RasGAP functions. Localized at the cell periphery, these proteins modulate Ras and Rab activity, thereby integrating autophagy with small GTPase signaling dynamics."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, age-related declines in muscle function—characteristic of sarcopenia—have been linked to reduced TP53INP2 levels. In mouse and human studies, reactivation of TP53INP2 in skeletal muscle restored autophagy, enhanced mitophagy, diminished oxidative stress, and ultimately improved muscle mass and function, emphasizing its potential in healthy aging."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFinally, emerging evidence suggests that TP53INP2 may impact the course of spinal cord injury by modulating inflammatory responses and neuronal apoptosis, thereby offering a potential target for therapeutic intervention in this devastating neurological disorder."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "David Sala, Saška Ivanova, Natàlia Plana, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Autophagy-regulating TP53INP2 mediates muscle wasting and is repressed in diabetes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI72327"}], "href": "https://doi.org/10.1172/JCI72327"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24713655"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24713655"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Montserrat Romero, Alba Sabaté-Pérez, Víctor A Francis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TP53INP2 regulates adiposity by activating β-catenin through autophagy-dependent sequestration of GSK3β."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41556-018-0072-9"}], "href": "https://doi.org/10.1038/s41556-018-0072-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29593329"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29593329"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hamish Crerar, Emily Scott-Solomon, Chantal Bodkin-Clarke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of NGF Signaling by an Axonal Untranslated mRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuron (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuron.2019.02.011"}], "href": "https://doi.org/10.1016/j.neuron.2019.02.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30853298"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30853298"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hiroyuki Nagai, Sayaka Yasuda, Yusuke Ohba, et al. "}, {"type": "b", "children": [{"type": "t", "text": "All members of the EPI64 subfamily of TBC/RabGAPs also have GAP activities towards Ras."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jb/mvs147"}], "href": "https://doi.org/10.1093/jb/mvs147"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23248241"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23248241"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "David Sebastián, Marc Beltrà, Andrea Irazoki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TP53INP2-dependent activation of muscle autophagy ameliorates sarcopenia and promotes healthy aging."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15548627.2024.2333717"}], "href": "https://doi.org/10.1080/15548627.2024.2333717"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38545813"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38545813"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Penghao Sun, Jinchuan Chen, Rujie Qin "}, {"type": "b", "children": [{"type": "t", "text": "TP53INP2 knockdown inhibits inflammatory response and apoptosis after spinal cord injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immun Inflamm Dis (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/iid3.1256"}], "href": "https://doi.org/10.1002/iid3.1256"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38652010"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38652010"}]}]}]}
Synonyms	GAPCENA, TBC1D11
Proteins	RBGP1_HUMAN
NCBI Gene ID	23637
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RABGAP1 has 6,549 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 119 datasets.

Click the + buttons to view associations for RABGAP1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RABGAP1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RABGAP1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of RABGAP1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of RABGAP1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of RABGAP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RABGAP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RABGAP1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RABGAP1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RABGAP1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RABGAP1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of RABGAP1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RABGAP1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of RABGAP1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with RABGAP1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with RABGAP1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RABGAP1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RABGAP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RABGAP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of RABGAP1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing RABGAP1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RABGAP1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RABGAP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing RABGAP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RABGAP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RABGAP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RABGAP1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RABGAP1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with RABGAP1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with RABGAP1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by RABGAP1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with RABGAP1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RABGAP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RABGAP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RABGAP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RABGAP1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RABGAP1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of RABGAP1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing RABGAP1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with RABGAP1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of RABGAP1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with RABGAP1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.