| HGNC Family | Ras small GTPases superfamily, Endogenous ligands |
| Name | ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) |
| Description | The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRAC3 is a member of the Rac subfamily of small GTPases that plays a crucial role in modulating cytoskeletal dynamics, cell adhesion, and motility. Studies using RNA interference have revealed that while related GTPases such as Rac1 are potent regulators of lamellipodia formation and cell migration, RAC3 may exert distinct effects on cell–cell junctions and actin remodeling, thereby influencing processes like E‐cadherin disassembly and integrin‐mediated adhesion. Notably, in neuronal cells RAC3 can oppose the actions of Rac1—altering cell‐matrix adhesions and neurite outgrowth—and also functions as a nuclear co‐activator for receptors such as estrogen receptor α, thereby promoting pro‐migratory and pro‐proliferative gene expression. These findings highlight RAC3’s multifaceted role in regulating both cytoskeletal organization and transcriptional programs."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the oncological context, RAC3 overexpression or dysregulation is increasingly being linked to tumor progression and metastasis across a wide variety of cancers. In lung, breast, esophageal, and brain tumors, RAC3 promotes invasive behavior by modulating epithelial‐mesenchymal transition (EMT), invadopodia formation, and extracellular matrix degradation. At the molecular level, RAC3 influences key signaling pathways—including those mediated by PAK1, ERK1/2, and JNK/MAPK—as well as post‐translational modifications such as site‐specific ubiquitination, thereby affecting cell cycle regulators (for example, CCND1 and MYC) and anti‐apoptotic mechanisms. Moreover, bioinformatics and functional studies in bladder and endometrial cancers have demonstrated that elevated RAC3 expression correlates with advanced stage, poor differentiation, chemoresistance, and adverse clinical outcomes, with upstream regulators (such as KLF1) further contributing to its pathological effects."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its oncogenic roles, emerging evidence links constitutional dysregulation and de novo variants of RAC3 to neurodevelopmental disorders characterized by intellectual disability, epilepsy, and diverse brain malformations. Investigations using in utero electroporation and in vitro biochemical assays have revealed that missense variants—especially those affecting the switch regions critical for GTPase activity—lead to aberrant RAC3 signaling. These alterations disrupt normal neuronal migration and cortical organization, thereby broadening the phenotypic spectrum of “neuro‐RACopathies” and underscoring the importance of finely tuned RAC3 activity during brain development."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "20", "end_ref": "23"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Amanda Y Chan, Salvatore J Coniglio, Ya-yu Chuang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/bcr1329"}], "href": "https://doi.org/10.1186/bcr1329"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16280046"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16280046"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Amra Hajdo-Milasinović, Saskia I J Ellenbroek, Saskia van Es, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rac1 and Rac3 have opposing functions in cell adhesion and differentiation of neuronal cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.03364"}], "href": "https://doi.org/10.1242/jcs.03364"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17244648"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17244648"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Encarnación Lozano, Marieke A M Frasa, Katarzyna Smolarczyk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PAK is required for the disruption of E-cadherin adhesion by the small GTPase Rac."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.016121"}], "href": "https://doi.org/10.1242/jcs.016121"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18319303"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18319303"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Amra Hajdo-Milasinovic, Rob A van der Kammen, Zvezdana Moneva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rac3 inhibits adhesion and differentiation of neuronal cells by modifying GIT1 downstream signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.039958"}], "href": "https://doi.org/10.1242/jcs.039958"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19494130"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19494130"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "M P Walker, M Zhang, T P Le, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "F-box protein complex FBXL19 regulates TGFβ1-induced E-cadherin down-regulation by mediating Rac3 ubiquitination and degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1476-4598-13-76"}], "href": "https://doi.org/10.1186/1476-4598-13-76"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24684802"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24684802"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Tie-Qin Liu, Ge-Bang Wang, Zheng-Jun Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing of Rac3 inhibits proliferation and induces apoptosis of human lung cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian Pac J Cancer Prev (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7314/apjcp.2015.16.7.3061"}], "href": "https://doi.org/10.7314/apjcp.2015.16.7.3061"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25854406"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25854406"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Gebang Wang, Huan Wang, Chenlei Zhang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201704048"}], "href": "https://doi.org/10.1083/jcb.201704048"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29061650"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29061650"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Mei Chen, Zhenyu Nie, Hui Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rac3 Expression and its Clinicopathological Significance in Patients With Bladder Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Oncol Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/pore.2021.598460"}], "href": "https://doi.org/10.3389/pore.2021.598460"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34257551"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34257551"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Cai Meijuan, Liu Fang, Fang Min, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypomethylated gene RAC3 induces cell proliferation and invasion by increasing FASN expression in endometrial cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biochem Cell Biol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biocel.2022.106274"}], "href": "https://doi.org/10.1016/j.biocel.2022.106274"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35917927"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35917927"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Yuelong Chen, Ming Huang, Junlin Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Establishment of a prognostic model to predict chemotherapy response and identification of RAC3 as a chemotherapeutic target in bladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Environ Toxicol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/tox.23860"}], "href": "https://doi.org/10.1002/tox.23860"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37310098"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37310098"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Haodong Li, Hongxuan Ma, JianHua Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Unveiling the role of RAC3 in the growth and invasion of cisplatin-resistant bladder cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.18473"}], "href": "https://doi.org/10.1111/jcmm.18473"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38847477"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38847477"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Lide Song, Qi Xu, Rong Chen, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "A de novo variant in RAC3 causes severe global developmental delay and a middle interhemispheric variant of holoprosencephaly."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hum Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s10038-019-0656-7"}], "href": "https://doi.org/10.1038/s10038-019-0656-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31420595"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31420595"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Marcello Scala, Masashi Nishikawa, Koh-Ichi Nagata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pathophysiological Mechanisms in Neurodevelopmental Disorders Caused by Rac GTPases Dysregulation: What's behind Neuro-RACopathies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells10123395"}], "href": "https://doi.org/10.3390/cells10123395"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34943902"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34943902"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Masashi Nishikawa, Marcello Scala, Muhammad Umair, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gain-of-function p.F28S variant in "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "RAC3"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " disrupts neuronal differentiation, migration and axonogenesis during cortical development, leading to neurodevelopmental disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Genet (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jmedgenet-2022-108483"}], "href": "https://doi.org/10.1136/jmedgenet-2022-108483"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35595279"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35595279"}]}]}]}
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| Proteins | RAC3_HUMAN |
| NCBI Gene ID | 5881 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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RAC3 has 6,494 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 101 datasets.
Click the + buttons to view associations for RAC3 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Achilles Cell Line Gene Essentiality Profiles | cell lines with fitness changed by RAC3 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset. | |
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of RAC3 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of RAC3 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of RAC3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of RAC3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of RAC3 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of RAC3 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of RAC3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of RAC3 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of RAC3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of RAC3 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with RAC3 gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of RAC3 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of RAC3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of RAC3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of RAC3 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing RAC3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with RAC3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of RAC3 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with RAC3 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Chemical Interactions | chemicals interacting with RAC3 gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
| CTD Gene-Disease Associations | diseases associated with RAC3 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| DeepCoverMOA Drug Mechanisms of Action | small molecule perturbations with high or low expression of RAC3 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by RAC3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Curated Gene-Disease Association Evidence Scores 2025 | diseases involving RAC3 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with RAC3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with RAC3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with RAC3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with RAC3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with RAC3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at RAC3 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of RAC3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of RAC3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing RAC3 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of RAC3 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with RAC3 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing RAC3 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of RAC3 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of RAC3 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of RAC3 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of RAC3 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of RAC3 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of RAC3 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving RAC3 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving RAC3 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing RAC3 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing RAC3 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by RAC3 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by RAC3 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of RAC3 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of RAC3 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of RAC3 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of RAC3 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of RAC3 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HMDB Metabolites of Enzymes | interacting metabolites for RAC3 protein from the curated HMDB Metabolites of Enzymes dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of RAC3 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of RAC3 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of RAC3 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of RAC3 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| HPM Cell Type and Tissue Protein Expression Profiles | cell types and tissues with high or low expression of RAC3 protein relative to other cell types and tissues from the HPM Cell Type and Tissue Protein Expression Profiles dataset. | |
| Hub Proteins Protein-Protein Interactions | interacting hub proteins for RAC3 from the curated Hub Proteins Protein-Protein Interactions dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for RAC3 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of RAC3 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEGG Pathways | pathways involving RAC3 protein from the KEGG Pathways dataset. | |
| Kinase Library Serine Threonine Kinome Atlas | kinases that phosphorylate RAC3 protein from the Kinase Library Serine Threonine Atlas dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of RAC3 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of RAC3 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with RAC3 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of RAC3 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of RAC3 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of RAC3 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain RAC3 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by RAC3 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MiRTarBase microRNA Targets | microRNAs targeting RAC3 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of RAC3 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by RAC3 gene mutations from the MPO Gene-Phenotype Associations dataset. | |
| MSigDB Cancer Gene Co-expression Modules | co-expressed genes for RAC3 from the MSigDB Cancer Gene Co-expression Modules dataset. | |
| MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of RAC3 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
| PANTHER Pathways | pathways involving RAC3 protein from the PANTHER Pathways dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for RAC3 from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of RAC3 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of RAC3 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving RAC3 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving RAC3 protein from the Wikipathways PFOCR 2024 dataset. | |
| Reactome Pathways 2014 | pathways involving RAC3 protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving RAC3 protein from the Reactome Pathways 2024 dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of RAC3 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of RAC3 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at RAC3 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of RAC3 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of RAC3 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Sanger Dependency Map Cancer Cell Line Proteomics | cell lines associated with RAC3 protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset. | |
| SynGO Synaptic Gene Annotations | synaptic terms associated with RAC3 gene from the SynGO Synaptic Gene Annotations dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of RAC3 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of RAC3 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of RAC3 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of RAC3 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of RAC3 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with RAC3 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| WikiPathways Pathways 2014 | pathways involving RAC3 protein from the Wikipathways Pathways 2014 dataset. | |
| WikiPathways Pathways 2024 | pathways involving RAC3 protein from the WikiPathways Pathways 2024 dataset. | |
