RANBP1 Gene

Name	RAN binding protein 1
Description	This gene encodes a protein that forms a complex with Ras-related nuclear protein (Ran) and metabolizes guanoside triphosphate (GTP). This complex participates in the regulation of the cell cycle by controlling transport of proteins and nucleic acids into the nucleus. There are multiple pseudogenes for this gene on chromosomes 9, 12, 17, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRanBP1 is a pivotal regulator of Ran‐GTPase signaling that coordinates key events during cell cycle progression. Kinetic analyses show that although RanBP1 does not affect the rate‐limiting GTP cleavage step, it dramatically accelerates the association between Ran and its GTPase–activating protein, facilitating efficient nucleotide exchange."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In human cells, depletion of RanBP1 delays prometaphase by promoting hyperstabilization of mitotic spindles and mislocalization of microtubule regulators, which can culminate in lagging chromosomes and aneuploidy. Moreover, through the formation of complexes with Ran‐GDP and importin‑β, RanBP1 plays a central role in nuclear import, and its tightly regulated down‐regulation during telophase is critical for nuclear reorganization."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Phosphorylation by mitotic kinases such as Polo‑like kinase 1 modulates its interactions with Ran, thereby ensuring proper microtubule nucleation and spindle assembly."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn cancer cells, RanBP1 is emerging as a critical mediator of both mitotic fidelity and chemotherapeutic response. Its expression is regulated by Sgk1 such that alterations in RanBP1 levels impact microtubule dynamics and determine taxol sensitivity; indeed, reduced RanBP1 expression not only triggers caspase‑3–dependent apoptosis upon microtubule stabilization but also enhances the apoptotic response to taxol treatment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " In addition, interaction studies have revealed that the intracellular domain of CD147 binds to the C‑terminal tail of RanBP1 to modulate microtubule stability, implicating this partnership in paclitaxel resistance. Elevated RanBP1 expression is further associated with cancer stem cell characteristics – including enhanced expression of stem cell markers, epithelial–mesenchymal transition, and altered cytokine production (notably IL‑18) – features that correlate with a poor patient prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its functions during mitosis and in cancer, RanBP1 is implicated in distinct physiological and pathological processes. Genetic analyses have linked polymorphisms in the RANBP1 gene to neurophysiological endophenotypes such as deficits in smooth pursuit eye movement observed in schizophrenia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " Furthermore, under conditions of oxidative stress, signaling through the epidermal growth factor receptor and protein kinase A modulates RanBP1’s nucleocytoplasmic shuttling via specific phosphorylation sites, underscoring its role as an integration point for stress‐responsive signaling pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Michael J Seewald, Astrid Kraemer, Marian Farkasovsky, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Biochemical characterization of the Ran-RanBP1-RanGAP system: are RanBP proteins and the acidic tail of RanGAP required for the Ran-RanGAP GTPase reaction?"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.23.22.8124-8136.2003"}], "href": "https://doi.org/10.1128/MCB.23.22.8124-8136.2003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14585972"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14585972"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Antonio Tedeschi, Marilena Ciciarello, Rosamaria Mangiacasale, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RANBP1 localizes a subset of mitotic regulatory factors on spindle microtubules and regulates chromosome segregation in human cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.009308"}], "href": "https://doi.org/10.1242/jcs.009308"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17940066"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17940066"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Thierry G Lonhienne, Jade K Forwood, Mary Marfori, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Importin-beta is a GDP-to-GTP exchange factor of Ran: implications for the mechanism of nuclear import."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.019935"}], "href": "https://doi.org/10.1074/jbc.M109.019935"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19549784"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19549784"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Marilena Ciciarello, Emanuele Roscioli, Barbara Di Fiore, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear reformation after mitosis requires downregulation of the Ran GTPase effector RanBP1 in mammalian cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Chromosoma (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00412-010-0286-5"}], "href": "https://doi.org/10.1007/s00412-010-0286-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20658144"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20658144"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hyo-In Hwang, Jae-Hoon Ji, Young-Joo Jang "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation of Ran-binding protein-1 by Polo-like kinase-1 is required for interaction with Ran and early mitotic progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.255620"}], "href": "https://doi.org/10.1074/jbc.M111.255620"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21813642"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21813642"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ka Chun Yau, Alexei Arnaoutov, Vasilisa Aksenova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RanBP1 controls the Ran pathway in mammalian cells through regulation of mitotic RCC1 dynamics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2020.1782036"}], "href": "https://doi.org/10.1080/15384101.2020.1782036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32594833"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32594833"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "W M Rensen, E Roscioli, A Tedeschi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RanBP1 downregulation sensitizes cancer cells to taxol in a caspase-3-dependent manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2009.24"}], "href": "https://doi.org/10.1038/onc.2009.24"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19270727"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19270727"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "R Amato, D Scumaci, L D'Antona, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sgk1 enhances RANBP1 transcript levels and decreases taxol sensitivity in RKO colon carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2012.470"}], "href": "https://doi.org/10.1038/onc.2012.470"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23108393"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23108393"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Gang Nan, Shu-Hua Zhao, Ting Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CD147 supports paclitaxel resistance via interacting with RanBP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-021-02143-3"}], "href": "https://doi.org/10.1038/s41388-021-02143-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34974521"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34974521"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yeon-Jee Kahm, In-Gyu Kim, Rae-Kwon Kim "}, {"type": "b", "children": [{"type": "t", "text": "RanBP1: A Potential Therapeutic Target for Cancer Stem Cells in Lung Cancer and Glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms24076855"}], "href": "https://doi.org/10.3390/ijms24076855"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37047826"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37047826"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Hyun Sub Cheong, Byung Lae Park, Eun Mi Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of RANBP1 haplotype with smooth pursuit eye movement abnormality."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet B Neuropsychiatr Genet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.b.31139"}], "href": "https://doi.org/10.1002/ajmg.b.31139"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21184585"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21184585"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Mohamed Kodiha, Nabila Azad, Siwei Chu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oxidative stress and signaling through EGFR and PKA pathways converge on the nuclear transport factor RanBP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Cell Biol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejcb.2023.151376"}], "href": "https://doi.org/10.1016/j.ejcb.2023.151376"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38011756"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38011756"}]}]}]}
Synonyms	HTF9A
Proteins	RANG_HUMAN
NCBI Gene ID	5902
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RANBP1 has 11,885 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 126 datasets.

Click the + buttons to view associations for RANBP1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RANBP1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by RANBP1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RANBP1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of RANBP1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of RANBP1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RANBP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RANBP1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving RANBP1 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RANBP1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RANBP1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RANBP1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of RANBP1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RANBP1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of RANBP1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with RANBP1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with RANBP1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RANBP1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RANBP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RANBP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RANBP1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RANBP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing RANBP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RANBP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RANBP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing RANBP1 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RANBP1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RANBP1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with RANBP1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with RANBP1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of RANBP1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RANBP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RANBP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RANBP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RANBP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RANBP1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RANBP1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of RANBP1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing RANBP1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with RANBP1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with RANBP1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of RANBP1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.