RANBP10 Gene

Name	RAN binding protein 10
Description	RAN is a small GTPase involved in the assembly of microtubules to form mitotic spindles. The protein encoded by this gene is a cytoplasmic guanine nucleotide exchange factor (GEF) that binds beta-tubulin and has GEF activity toward RAN. The encoded protein plays a role in the formation of noncentrosomal microtubules. In addition, this protein may be involved in the regulation of D(1) receptor signaling by protein kinase C delta and protein kinase C gamma. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRANBP10 functions as a versatile regulator of microtubule dynamics in specialized cells. In megakaryocytes, it binds beta‐tubulin and, through its guanine nucleotide exchange factor (GEF) activity, locally generates Ran.GTP to organize noncentrosomal microtubules essential for proplatelet formation and subsequent thrombopoiesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nIn the neuronal context, elevated RANBP10 levels are detrimental. miR-196a confers neuroprotection in Huntington’s disease by suppressing RANBP10 expression, which in turn improves neuronal morphology, enhances β-tubulin polymerization, and supports intracellular transport, thereby mitigating pathological protein aggregation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n\nRANBP10 also serves as a modulator of receptor signaling pathways. Its interaction with protein kinase C isoforms (PKCγ and PKCδ) regulates the phosphorylation state of the D1 dopamine receptor; overexpression of RANBP10 enhances basal receptor phosphorylation and attenuates receptor-mediated cAMP production, suggesting a role in fine-tuning signal transduction."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n\nIn viral infections, RANBP10 acts as a transcriptional coactivator. During herpes simplex virus type 1 (HSV-1) infection, it interacts with the viral regulatory protein ICP0 to promote viral gene expression by modulating chromatin organization; its depletion results in greater histone H3 association with viral promoters and reduced transcription of immediate early, early, and late viral genes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n\nMoreover, RANBP10 is implicated in the nuclear import of viral genomes. In human papillomavirus (HPV) infection, it forms a novel transport complex with karyopherin alpha2 (KPNA2) and dynein light chain (DYNLT3), which facilitates the delivery of the L2/vDNA subviral complex into the nucleus by promoting its association with mitotic chromatin."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n\nIn oncology, particularly glioblastoma (GBM), RANBP10 is overexpressed and associated with poor clinical outcomes. It contributes to tumor progression by suppressing the promoter activity of the tumor suppressor FBXW7, leading to increased stability of the oncogene c-Myc and enhancing cellular proliferation, migration, invasion, and overall tumor growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Harald Schulze, Marei Dose, Manav Korpal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M709397200"}], "href": "https://doi.org/10.1074/jbc.M709397200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18347012"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18347012"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lu-Shiun Her, Su-Han Mao, Chih-Yi Chang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-196a Enhances Neuronal Morphology through Suppressing RANBP10 to Provide Neuroprotection in Huntington's Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Theranostics (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/thno.18813"}], "href": "https://doi.org/10.7150/thno.18813"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28744327"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28744327"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Elizabeth B Rex, Michele L Rankin, Yu Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of RanBP 9/10 as interacting partners for protein kinase C (PKC) gamma/delta and the D1 dopamine receptor: regulation of PKC-mediated receptor phosphorylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Pharmacol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/mol.110.063727"}], "href": "https://doi.org/10.1124/mol.110.063727"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20395553"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20395553"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yuka Sato, Akihisa Kato, Yuhei Maruzuru, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cellular Transcriptional Coactivator RanBP10 and Herpes Simplex Virus 1 ICP0 Interact and Synergistically Promote Viral Gene Expression and Replication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.03043-15"}], "href": "https://doi.org/10.1128/JVI.03043-15"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26739050"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26739050"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Kun-Yi Lai, Matteo Rizzato, Inci Aydin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Ran-binding protein facilitates nuclear import of human papillomavirus type 16."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Pathog (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.ppat.1009580"}], "href": "https://doi.org/10.1371/journal.ppat.1009580"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33974675"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33974675"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jianbing Hou, Yudong Liu, Pan Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RANBP10 promotes glioblastoma progression by regulating the FBXW7/c-Myc pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-04207-4"}], "href": "https://doi.org/10.1038/s41419-021-04207-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34671019"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34671019"}]}]}]}
Proteins	RBP10_HUMAN
NCBI Gene ID	57610
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RANBP10 has 5,376 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 112 datasets.

Click the + buttons to view associations for RANBP10 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RANBP10 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RANBP10 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of RANBP10 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of RANBP10 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of RANBP10 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RANBP10 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RANBP10 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RANBP10 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RANBP10 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RANBP10 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RANBP10 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of RANBP10 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with RANBP10 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with RANBP10 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RANBP10 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RANBP10 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RANBP10 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RANBP10 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RANBP10 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing RANBP10 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RANBP10 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RANBP10 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RANBP10 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RANBP10 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with RANBP10 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with RANBP10 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of RANBP10 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by RANBP10 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with RANBP10 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RANBP10 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RANBP10 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RANBP10 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RANBP10 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RANBP10 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RANBP10 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of RANBP10 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing RANBP10 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of RANBP10 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with RANBP10 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing RANBP10 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of RANBP10 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.