RANGAP1 Gene

Name	Ran GTPase activating protein 1
Description	This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRanGAP1 acts as a central regulator of nucleocytoplasmic transport by catalyzing RanGTP hydrolysis. Its function depends on its post‐translational modification by SUMO-1 – a process that, while achievable by the E2 enzyme Ubc9 alone, is markedly enhanced by the SUMO E3 ligase activity of nucleoporins such as Nup358/RanBP2. Structural and biochemical studies reveal that once conjugated to SUMO, RanGAP1 behaves nearly as a “bead-on-a-string,” maintaining intrinsic flexibility that facilitates formation of stable complexes with Ran and RanBP1. Phosphorylation events, notably at serine 358 by casein kinase II, further modulate its ability to form these complexes. In addition, interactions with factors like the immune adaptor SLP-76 promote its association with the RanBP2/RanGAP1-SUMO complex, thereby ensuring efficient nuclear export of transcription regulators in T cells."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in nucleocytoplasmic trafficking, RanGAP1 is essential for maintaining mitotic fidelity. Its recruitment to kinetochores and subsequent interaction with spindle-associated proteins—such as NUSAP1—contributes to proper spindle assembly and chromosome segregation. Deficiency or misregulation of RanGAP1 can lead to hyperactivation of the spindle assembly checkpoint, failure in chromatid decatenation, and even chromosomal fragmentation (chromothripsis), events that underline its importance in cell division and genome stability."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAberrant expression or mislocalization of RanGAP1 is implicated in several disease processes. Upregulation of a circular RNA form of RanGAP1 is linked to enhanced invasion and migration in gastric cancer through a miRNA sponging mechanism, while in chronic myeloid leukemia, reduction of RanGAP1 results in nuclear entrapment of the oncogenic fusion protein BCR-ABL, thereby potentiating the apoptotic response to imatinib. In neurodegenerative disorders like Huntington’s disease, sequestration of RanGAP1 disrupts nuclear envelope integrity and messenger RNA export. Moreover, dynamic changes in RanGAP1 levels significantly impact vascular smooth muscle cell differentiation in proliferative vascular diseases, and in gliomas, altered SUMOylation of RanGAP1 modulates the TGF-β/Smad signaling pathway. Preliminary findings also indicate that RanGAP1, in concert with other factors such as KDM2A, may contribute to HBV core protein–mediated hepatocarcinogenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Matthew S Macauley, Wesley J Errington, Mark Okon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural and dynamic independence of isopeptide-linked RanGAP1 and SUMO-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M408705200"}], "href": "https://doi.org/10.1074/jbc.M408705200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15355965"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15355965"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "David Reverter, Christopher D Lima "}, {"type": "b", "children": [{"type": "t", "text": "Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature03588"}], "href": "https://doi.org/10.1038/nature03588"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15931224"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15931224"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Eri Takeda, Miki Hieda, Jun Katahira, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation of RanGAP1 stabilizes its interaction with Ran and RanBP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Struct Funct (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1247/csf.30.69"}], "href": "https://doi.org/10.1247/csf.30.69"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16428860"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16428860"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jaclyn R Gareau, David Reverter, Christopher D Lima "}, {"type": "b", "children": [{"type": "t", "text": "Determinants of small ubiquitin-like modifier 1 (SUMO1) protein specificity, E3 ligase, and SUMO-RanGAP1 binding activities of nucleoporin RanBP2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.321141"}], "href": "https://doi.org/10.1074/jbc.M111.321141"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22194619"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22194619"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hebin Liu, Helga Schneider, Asha Recino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Immune Adaptor SLP-76 Binds to SUMO-RANGAP1 at Nuclear Pore Complex Filaments to Regulate Nuclear Import of Transcription Factors in T Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2015.07.015"}], "href": "https://doi.org/10.1016/j.molcel.2015.07.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26321253"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26321253"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Elodie Blondel-Tepaz, Marie Leverve, Badr Sokrat, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The RanBP2/RanGAP1-SUMO complex gates β-arrestin2 nuclear entry to regulate the Mdm2-p53 signaling axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-021-01704-w"}], "href": "https://doi.org/10.1038/s41388-021-01704-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33649538"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33649538"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Christine A Mills, Aussie Suzuki, Anthony Arceci, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nucleolar and spindle-associated protein 1 (NUSAP1) interacts with a SUMO E3 ligase complex during chromosome segregation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M117.796045"}], "href": "https://doi.org/10.1074/jbc.M117.796045"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28900032"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28900032"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Zhuang Zhang, Rubo Sui, Lili Ge, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircRNA_0079586 and circRNA_RanGAP1 are involved in the pathogenesis of intracranial aneurysms rupture by regulating the expression of MPO."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-021-99062-w"}], "href": "https://doi.org/10.1038/s41598-021-99062-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34611229"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34611229"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Marc Vorpahl, Sabine Schönhofer-Merl, Cornelia Michaelis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Ran GTPase-activating protein (RanGAP1) is critically involved in smooth muscle cell differentiation, proliferation and migration following vascular injury: implications for neointima formation and restenosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0101519"}], "href": "https://doi.org/10.1371/journal.pone.0101519"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24988324"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24988324"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Tsung-Yao Lin, Ku-Chung Chen, Hsing-Jin Eugene Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-1301-Mediated RanGAP1 Downregulation Induces BCR-ABL Nuclear Entrapment to Enhance Imatinib Efficacy in Chronic Myeloid Leukemia Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0156260"}], "href": "https://doi.org/10.1371/journal.pone.0156260"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27228340"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27228340"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Fatima Gasset-Rosa, Carlos Chillon-Marinas, Alexander Goginashvili, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuron (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuron.2017.03.027"}], "href": "https://doi.org/10.1016/j.neuron.2017.03.027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28384474"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28384474"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Jun Lu, Yao-Hui Wang, Changhwan Yoon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA circ-RanGAP1 regulates VEGFA expression by targeting miR-877-3p to facilitate gastric cancer invasion and metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2019.11.038"}], "href": "https://doi.org/10.1016/j.canlet.2019.11.038"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31811909"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31811909"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Jiao Fan, Yang Liu, Yiping Zhong "}, {"type": "b", "children": [{"type": "t", "text": "Immunization with CENP-C Causes Aberrant Chromosome Segregation during Oocyte Meiosis in Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/4610494"}], "href": "https://doi.org/10.1155/2021/4610494"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33604391"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33604391"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Hong-Juan You, Li-Hong Ma, Xing Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hepatitis B virus core protein stabilizes RANGAP1 to upregulate KDM2A and facilitate hepatocarcinogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Oncol (Dordr) (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13402-023-00889-4"}], "href": "https://doi.org/10.1007/s13402-023-00889-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37845585"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37845585"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Feng Zhang, Jun Yang, Yifei Cheng "}, {"type": "b", "children": [{"type": "t", "text": "Impact of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "RANGAP1 "}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "SUMOylation on Smad4 nuclear export by bioinformatic analysis and cell assays."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomol Biomed (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.17305/bb.2024.10443"}], "href": "https://doi.org/10.17305/bb.2024.10443"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38801243"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38801243"}]}]}]}
Synonyms	FUG1, SD, RANGAP
Proteins	RAGP1_HUMAN
NCBI Gene ID	5905
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RANGAP1 has 10,235 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 131 datasets.

Click the + buttons to view associations for RANGAP1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RANGAP1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RANGAP1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of RANGAP1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of RANGAP1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of RANGAP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RANGAP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RANGAP1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving RANGAP1 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RANGAP1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RANGAP1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RANGAP1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of RANGAP1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RANGAP1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of RANGAP1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with RANGAP1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with RANGAP1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RANGAP1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RANGAP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RANGAP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing RANGAP1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RANGAP1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RANGAP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing RANGAP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing RANGAP1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RANGAP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RANGAP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RANGAP1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RANGAP1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with RANGAP1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with RANGAP1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with RANGAP1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RANGAP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RANGAP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RANGAP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RANGAP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RANGAP1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RANGAP1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of RANGAP1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing RANGAP1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of RANGAP1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with RANGAP1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.