RAP2A Gene

HGNC Family	Ras small GTPases superfamily
Name	RAP2A, member of RAS oncogene family
Description	Enables GTPase activity; guanyl ribonucleotide binding activity; and magnesium ion binding activity. Involved in several processes, including microvillus assembly; positive regulation of protein autophosphorylation; and regulation of dendrite morphogenesis. Acts upstream of or within establishment of protein localization. Located in plasma membrane and recycling endosome membrane. Is active in Schaffer collateral - CA1 synapse. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRAP2A, a member of the Ras‐related small GTPase superfamily, functions as a versatile molecular switch that translates extracellular and mechanical cues into intracellular responses. Several studies have demonstrated that RAP2A relays extracellular matrix rigidity signals to regulate mechanosensitive pathways—for example, controlling the Hippo effectors YAP/TAZ and modulating actin cytoskeletal reorganization via effectors such as TNIK and MAP4K4. In polarized epithelial cells, RAP2A also couples apicobasal polarity with brush border (microvillus) formation, thereby contributing to the spatial organization of the cell."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn immune and vascular contexts, RAP2A plays a critical role in regulating cell adhesion, migration, and barrier function. In neutrophils and T lymphocytes, RAP2A is rapidly activated upon integrin engagement, thereby orchestrating cytoskeletal dynamics and directional cell movement. In endothelial cells, RAP2A signaling—often acting reciprocally to Rap1—modulates junctional protein expression and barrier permeability, a function further evidenced under conditions of altered mechanical stress."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nWithin the nervous system, RAP2A contributes to the fine tuning of synaptic plasticity by affecting dendritic spine morphology and synaptic strength. Its activity has been associated with promoting long‐term depression and reducing spine maintenance, thereby influencing learning and memory processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn oncogenesis, dysregulated RAP2A expression has been implicated in promoting tumor cell migration, invasion, and metastasis. Mechanistically, overexpression of RAP2A enhances signaling via pathways such as Akt and mTOR and increases the activities of matrix metalloproteinases, thus contributing to an aggressive malignant phenotype. Genetic studies have further linked polymorphisms at the RAP2A locus with susceptibility to peripheral arterial disease, and aberrantly high RAP2A levels have been reported in hepatocellular, pancreatic, breast, and lung cancers—highlighting its promise as both a prognostic marker and a therapeutic target."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, RAP2A is not only central to mammalian cell physiology but also plays a pivotal role in host–pathogen interactions. For instance, a parasite‐secreted RAP2A protein has been shown to be essential for Plasmodium falciparum invasion of erythrocytes, offering a novel target for anti‐malarial interventions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, these findings underscore RAP2A as a multifaceted regulator that integrates mechanical stimuli, cytoskeletal dynamics, and signaling cues to modulate cell polarity, adhesion, migration, synaptic plasticity, and tumor progression. With diverse roles spanning normal physiology to disease states, RAP2A continues to emerge as an attractive candidate for targeted therapeutic strategies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Noriko Machida, Masato Umikawa, Kimiko Takei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.C300542200"}], "href": "https://doi.org/10.1074/jbc.C300542200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14966141"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14966141"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kiyohito Taira, Masato Umikawa, Kimiko Takei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M406370200"}], "href": "https://doi.org/10.1074/jbc.M406370200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15342639"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15342639"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Martijn Gloerich, Jean Paul ten Klooster, Marjolein J Vliem, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rap2A links intestinal cell polarity to brush border formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb2537"}], "href": "https://doi.org/10.1038/ncb2537"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22797597"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22797597"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Zhipeng Meng, Yunjiang Qiu, Kimberly C Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RAP2 mediates mechanoresponses of the Hippo pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41586-018-0444-0"}], "href": "https://doi.org/10.1038/s41586-018-0444-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30135582"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30135582"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Chenzhou Wu, Xiaomin Cai, Ying Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interplay of RAP2 GTPase and the cytoskeleton in Hippo pathway regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jbc.2024.107257"}], "href": "https://doi.org/10.1016/j.jbc.2024.107257"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38574891"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38574891"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Fabio Greco, Annarita Ciana, Daniela Pietra, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rap2, but not Rap1 GTPase is expressed in human red blood cells and is involved in vesiculation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2006.02.001"}], "href": "https://doi.org/10.1016/j.bbamcr.2006.02.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16540189"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16540189"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Veronika Jenei, Ravi Kiran Deevi, Catherine Anne Adams, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nitric oxide produced in response to engagement of beta2 integrins on human neutrophils activates the monomeric GTPases Rap1 and Rap2 and promotes adhesion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M601335200"}], "href": "https://doi.org/10.1074/jbc.M601335200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16963453"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16963453"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Mandy Miertzschke, Paula Stanley, Tom D Bunney, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of interactions of adapter protein RAPL/Nore1B with RAP GTPases and their role in T cell migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M704361200"}], "href": "https://doi.org/10.1074/jbc.M704361200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17716979"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17716979"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Karim Dib, Lena Axelsson, Tommy Andersson "}, {"type": "b", "children": [{"type": "t", "text": "Beta2 integrins target Rap GTPases to the plasma membrane by means of degranulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2008.08.160"}], "href": "https://doi.org/10.1016/j.bbrc.2008.08.160"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18789886"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18789886"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Willem-Jan Pannekoek, Jelena R Linnemann, Patricia M Brouwer, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Constitutively active Rap2 transgenic mice display fewer dendritic spines, reduced extracellular signal-regulated kinase signaling, enhanced long-term depression, and impaired spatial learning and fear extinction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.1944-08.2008"}], "href": "https://doi.org/10.1523/JNEUROSCI.1944-08.2008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18701680"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18701680"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Jinxia Wu, Miaomiao Sang, Wenjia Cao, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Rap2a is a novel target gene of p53 and regulates cancer cell migration and invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2015.02.026"}], "href": "https://doi.org/10.1016/j.cellsig.2015.02.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25728512"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25728512"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Hui Huang, Jiehui Di, Debao Qu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of Rap2 and its Downstream Effectors in Tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anticancer Agents Med Chem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/1871520615666150518092840"}], "href": "https://doi.org/10.2174/1871520615666150518092840"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25980814"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25980814"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Mitsuru Matsukura, Kouichi Ozaki, Atsushi Takahashi, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Abnormal expression of Rap2A as a prognostic marker for human breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202009_23039"}], "href": "https://doi.org/10.26355/eurrev_202009_23039"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33015796"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33015796"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Jing-Ru Yang, Xiao-Ling Ling, Quan-Lin Guan "}, {"type": "b", "children": [{"type": "t", "text": "RAP2A promotes apoptosis resistance of hepatocellular carcinoma cells via the mTOR pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10238-021-00723-x"}], "href": "https://doi.org/10.1007/s10238-021-00723-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34018090"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34018090"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Kaizhou Jin, Chen Liu, He Cheng, et al. 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Synonyms	RAP2, RBBP-30, KREV
Proteins	RAP2A_HUMAN
NCBI Gene ID	5911
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RAP2A has 7,281 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 116 datasets.

Click the + buttons to view associations for RAP2A from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RAP2A Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by RAP2A gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RAP2A gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of RAP2A gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of RAP2A gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of RAP2A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RAP2A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RAP2A gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RAP2A gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RAP2A gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RAP2A gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of RAP2A gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RAP2A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of RAP2A gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with RAP2A protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with RAP2A gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RAP2A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RAP2A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RAP2A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RAP2A gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RAP2A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing RAP2A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RAP2A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RAP2A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RAP2A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RAP2A gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with RAP2A gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with RAP2A gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of RAP2A protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by RAP2A gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RAP2A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RAP2A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RAP2A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RAP2A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for RAP2A protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RAP2A gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RAP2A gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of RAP2A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing RAP2A from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD High Level Gene-Disease Associations	diseases associated with RAP2A gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of RAP2A gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.