RAPSN Gene

HGNC Family	Zinc fingers
Name	receptor-associated protein of the synapse
Description	This gene encodes a member of a family of proteins that are receptor associated proteins of the synapse. The encoded protein contains a conserved cAMP-dependent protein kinase phosphorylation site, and plays a critical role in clustering and anchoring nicotinic acetylcholine receptors at synaptic sites by linking the receptors to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin. Mutations in this gene may play a role in postsynaptic congenital myasthenic syndromes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRapsyn is a critical postsynaptic scaffolding protein that orchestrates neuromuscular junction (NMJ) formation by clustering nicotinic acetylcholine receptors (AChRs) at the motor endplate. Structurally, it harbors several domains that facilitate its function – multiple tetratricopeptide repeats (TPRs) mediate self-association, a coiled‐coil domain binds directly to AChRs, and a RING‐H2 domain couples rapsyn to the subsynaptic cytoskeleton via beta‐dystroglycan. In addition, recent studies have revealed that rapsyn undergoes liquid–liquid phase separation to form condensates that efficiently recruit AChRs and other postsynaptic components, while also directly immobilizing AChRs within confined membrane domains. These mechanisms underscore its pivotal role in NMJ maturation and maintenance."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nTranscriptional regulation of the RAPSN gene is mediated by key promoter elements. Specific consensus sequences, including E-boxes and binding sites for transcription factors such as Kaiso and its partner delta-catenin, have been shown to directly activate rapsyn expression in muscle cells. Mutations in these promoter regions, including alterations within E-box motifs, impair transcriptional activity and predict reduced rapsyn expression at the NMJ. These findings highlight the sophisticated control of gene expression that is crucial for proper synapse formation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMutations in RAPSN have been implicated in a spectrum of congenital myasthenic syndromes (CMS), with clinical severity ranging from mild fatigable weakness to lethal forms such as fetal akinesia. In many patients, the common N88K mutation is found either in homozygous form or compounded with additional mutations—including missense changes, frameshifts, large deletions, and even novel splice variants – that correlate with variation in endplate AChR density and postsynaptic morphological development. Epidemiological studies further reveal a founder effect in certain populations, underscoring the mutation-specific heterogeneity and its impact on disease outcome."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its classic role at the NMJ, rapsyn may also have functions in other cellular contexts. Altered methylation patterns of RAPSN in blood have been associated with breast cancer risk, suggesting an epigenetic dimension to its regulation that could serve as a potential biomarker. Moreover, recent evidence indicates that in cells lacking AChRs, rapsyn influences the distribution and mobility of lysosomes, implicating it in intracellular organelle organization and membrane integrity. These emerging roles expand our understanding of rapsyn as not only a synaptic organizer but also as a modulator of other cellular processes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "19", "end_ref": "22"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kinji Ohno, Andrew G Engel, Xin-Ming Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rapsyn mutations in humans cause endplate acetylcholine-receptor deficiency and myasthenic syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1086/339465"}], "href": "https://doi.org/10.1086/339465"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11791205"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11791205"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Vanessa Dunne, Ricardo A Maselli "}, {"type": "b", "children": [{"type": "t", "text": "Identification of pathogenic mutations in the human rapsyn gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hum Genet (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10038-003-0005-7"}], "href": "https://doi.org/10.1007/s10038-003-0005-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12730725"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12730725"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Brenda L Banwell, Kinji Ohno, Joern P Sieb, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel truncating RAPSN mutations causing congenital myasthenic syndrome responsive to 3,4-diaminopyridine."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuromuscul Disord (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.nmd.2003.11.004"}], "href": "https://doi.org/10.1016/j.nmd.2003.11.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15036330"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15036330"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "M Milone, X M Shen, D Selcen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Myasthenic syndrome due to defects in rapsyn: Clinical and molecular findings in 39 patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurology (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1212/WNL.0b013e3181ae7cbc"}], "href": "https://doi.org/10.1212/WNL.0b013e3181ae7cbc"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19620612"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19620612"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Guanglin Xing, Hongyang Jing, Lei Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A mechanism in agrin signaling revealed by a prevalent Rapsyn mutation in congenital myasthenic syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.49180"}], "href": "https://doi.org/10.7554/eLife.49180"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31549961"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31549961"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Guanglin Xing, Hongyang Jing, Zheng Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Membraneless condensates by Rapsn phase separation as a platform for neuromuscular junction formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuron (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuron.2021.04.021"}], "href": "https://doi.org/10.1016/j.neuron.2021.04.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34033754"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34033754"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Joachim Piguet, Christoph Schreiter, Jean-Manuel Segura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Acetylcholine receptor organization in membrane domains in muscle cells: evidence for rapsyn-independent and rapsyn-dependent mechanisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.139782"}], "href": "https://doi.org/10.1074/jbc.M110.139782"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20978122"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20978122"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xufeng Liao, Yingxing Wang, Xinsheng Lai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of Rapsyn in neuromuscular junction and congenital myasthenic syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomol Biomed (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.17305/bb.2022.8641"}], "href": "https://doi.org/10.17305/bb.2022.8641"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36815443"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36815443"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Marianna Rodova, Kevin F Kelly, Michael VanSaun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of the rapsyn promoter by kaiso and delta-catenin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.24.16.7188-7196.2004"}], "href": "https://doi.org/10.1128/MCB.24.16.7188-7196.2004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15282317"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15282317"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Kinji Ohno, Menachem Sadeh, Ilan Blatt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "E-box mutations in the RAPSN promoter region in eight cases with congenital myasthenic syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddg089"}], "href": "https://doi.org/10.1093/hmg/ddg089"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12651869"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12651869"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Esther Leshinsky-Silver, Daniel Shapira, Keren Yosovitz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel mutation in the TPR6 domain of the RAPSN gene associated with congenital myasthenic syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurol Sci (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jns.2012.01.012"}], "href": "https://doi.org/10.1016/j.jns.2012.01.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22326364"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22326364"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Vanessa Dunne, Ricardo A Maselli "}, {"type": "b", "children": [{"type": "t", "text": "Common founder effect of rapsyn N88K studied using intragenic markers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hum Genet (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10038-004-0159-y"}], "href": "https://doi.org/10.1007/s10038-004-0159-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15252722"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15252722"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Julie Vogt, Benjamin J Harrison, Hayley Spearman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutation analysis of CHRNA1, CHRNB1, CHRND, and RAPSN genes in multiple pterygium syndrome/fetal akinesia patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2007.09.016"}], "href": "https://doi.org/10.1016/j.ajhg.2007.09.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18179903"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18179903"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "J S Müller, S K Baumeister, V M Rasic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Impaired receptor clustering in congenital myasthenic syndrome with novel RAPSN mutations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurology (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1212/01.wnl.0000233837.79459.40"}], "href": "https://doi.org/10.1212/01.wnl.0000233837.79459.40"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16931511"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16931511"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Juliane S Müller, Angela Abicht, Hans-Jürgen Christen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A newly identified chromosomal microdeletion of the rapsyn gene causes a congenital myasthenic syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuromuscul Disord (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.nmd.2004.06.010"}], "href": "https://doi.org/10.1016/j.nmd.2004.06.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15482960"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15482960"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Sharon Aharoni, Menachem Sadeh, Yehuda Shapira, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Congenital myasthenic syndrome in Israel: Genetic and clinical characterization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuromuscul Disord (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.nmd.2016.11.014"}], "href": "https://doi.org/10.1016/j.nmd.2016.11.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28024842"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28024842"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Karen Gaudon, Isabelle Pénisson-Besnier, Brigitte Chabrol, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multiexon deletions account for 15% of congenital myasthenic syndromes with RAPSN mutations after negative DNA sequencing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jmg.2010.081034"}], "href": "https://doi.org/10.1136/jmg.2010.081034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20930056"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20930056"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Shivani Mishra, Karthik Vijay Nair, Anju Shukla "}, {"type": "b", "children": [{"type": "t", "text": "Delineation of molecular characteristics of congenital myasthenic syndromes in Indian families and review of literature."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Dysmorphol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MCD.0000000000000465"}], "href": "https://doi.org/10.1097/MCD.0000000000000465"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37646703"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37646703"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Qiuqiong Tang, Tim Holland-Letz, Alla Slynko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNA methylation array analysis identifies breast cancer associated RPTOR, MGRN1 and RAPSN hypomethylation in peripheral blood DNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.11640"}], "href": "https://doi.org/10.18632/oncotarget.11640"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27577081"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27577081"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Shuifang Lei, Lixi Li, Xiaoqin Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The association between RAPSN methylation in peripheral blood and breast cancer in the Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hum Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s10038-021-00933-x"}], "href": "https://doi.org/10.1038/s10038-021-00933-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33958711"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33958711"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Mohamed Aittaleb, Po-Ju Chen, Mohammed Akaaboune "}, {"type": "b", "children": [{"type": "t", "text": "Failure of lysosome clustering and positioning in the juxtanuclear region in cells deficient in rapsyn."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.172536"}], "href": "https://doi.org/10.1242/jcs.172536"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26330529"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26330529"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Espen Homleid Alseth, Angelina Hatlø Maniaol, Ahmed Elsais, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Investigation for RAPSN and DOK-7 mutations in a cohort of seronegative myasthenia gravis patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Muscle Nerve (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mus.21919"}], "href": "https://doi.org/10.1002/mus.21919"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21305573"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21305573"}]}]}]}
Synonyms	CMS11, RAPSYN, RNF205
Proteins	RAPSN_HUMAN
NCBI Gene ID	5913
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RAPSN has 6,462 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 118 datasets.

Click the + buttons to view associations for RAPSN from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RAPSN Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by RAPSN gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RAPSN gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of RAPSN gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of RAPSN gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of RAPSN gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RAPSN gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving RAPSN protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RAPSN gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RAPSN gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RAPSN gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of RAPSN gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RAPSN gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of RAPSN gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with RAPSN protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with RAPSN gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RAPSN gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RAPSN gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RAPSN gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with RAPSN gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with RAPSN gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RAPSN gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RAPSN protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing RAPSN protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing RAPSN protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RAPSN protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RAPSN protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RAPSN gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RAPSN gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with RAPSN gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with RAPSN gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with RAPSN gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by RAPSN gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving RAPSN gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving RAPSN gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with RAPSN gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RAPSN gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RAPSN gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RAPSN gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RAPSN gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RAPSN gene from the ENCODE Histone Modification Site Profiles dataset.