RASGRF2 Gene

HGNC Family	Rho guanine nucleotide exchange factors (ARHGEF), Pleckstrin homology domain containing (PLEKH)
Name	Ras protein-specific guanine nucleotide-releasing factor 2
Description	RAS GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This gene encodes a calcium-regulated nucleotide exchange factor activating both RAS and RAS-related protein, RAC1, through the exchange of bound GDP for GTP, thereby, coordinating the signaling of distinct mitogen-activated protein kinase pathways. [provided by RefSeq, Oct 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRASGRF2 is a member of the Ras guanine nucleotide–releasing factor family that facilitates GDP/GTP exchange on Ras family GTPases, thereby modulating key intracellular signaling pathways. It has been shown to activate H‐Ras at the plasma membrane and in the endoplasmic reticulum, with distinct domain requirements in different subcellular compartments."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, RasGRF2 is capable of activating TC21 when it is farnesylated, highlighting substrate‐specific determinants required for its exchange activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Notably, RasGRF2 has been implicated in the regulation of mesolimbic dopamine neuron activity and, by modulating ERK pathway activation in response to calcium, may influence reward sensitivity and alcohol intake. Indeed, mice lacking RasGRF2 display blunted dopamine release with reduced ethanol consumption, while a human haplotype including rs26907 is associated with altered ventral striatal responses during reward anticipation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Furthermore, insertion of a human endogenous retrovirus (HERV-K) element in the RASGRF2 gene alters its transcription and cellular phenotype, providing a potential mechanism linking RasGRF2 to addiction, a finding consistent with observed genetic associations with alcohol-related behaviors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in neuronal signaling, RasGRF2 contributes to immune cell function and cell motility. In T lymphocytes, RasGRF2 is recruited to the immune synapse upon T-cell receptor stimulation where it activates Ras and subsequently stimulates NF-AT–dependent signaling pathways, which are crucial for cytokine production."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Its function in T-cell activation is further underscored by evidence that both Vav1 and RasGRF2 serve as exchange factors for Ras superfamily GTPases in lymphocytes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Moreover, in studies of cellular morphology, RasGRF2 has been identified as a negative regulator of Cdc42 activation; by directly binding to Cdc42 and outcompeting its other activators, RasGRF2 modulates the balance between rounded and elongated cell migration modes, thereby influencing motility and invasiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRASGRF2 further appears to play nuanced roles in tumor biology. In non–small cell lung cancer, aberrant promoter methylation frequently silences RasGRF2, suggesting that loss of its expression may be an important event in lung carcinogenesis, independent of related tumor suppressors such as RASSF1A."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " In contrast, in colorectal cancer elevated RasGRF2 levels promote migration and invasion through upregulation of MMP9 and activation of Src/Akt–NF-κB signaling, indicating a pro-metastatic function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " Moreover, in triple-negative breast cancers, reciprocal expression between RasGRF2 and annexin A6 delineates highly proliferative tumors from more invasive subsets, with high RasGRF2 expression correlating with increased Ki67 positivity and poorer outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Finally, a single-nucleotide polymorphism in the RASGRF2 gene is associated with adverse overall survival in hepatitis B virus–related hepatocellular carcinoma, further underscoring the clinical relevance of RasGRF2 in cancer progression"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": ", while suggestive associations with malignant mesothelioma risk also support its role in tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Imanol Arozarena, David Matallanas, María T Berciano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.24.4.1516-1530.2004"}], "href": "https://doi.org/10.1128/MCB.24.4.1516-1530.2004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14749369"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14749369"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Fernando Calvo, Piero Crespo "}, {"type": "b", "children": [{"type": "t", "text": "Structural and spatial determinants regulating TC21 activation by RasGRF family nucleotide exchange factors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e09-03-0212"}], "href": "https://doi.org/10.1091/mbc.e09-03-0212"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19692568"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19692568"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "David Stacey, Ainhoa Bilbao, Matthieu Maroteaux, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RASGRF2 regulates alcohol-induced reinforcement by influencing mesolimbic dopamine neuron activity and dopamine release."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1211844110"}], "href": "https://doi.org/10.1073/pnas.1211844110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23223532"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23223532"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ignacio Novo-Veleiro, Clara Cieza-Borrella, Isabel Pastor, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Single Nucleotide Polymorphism in the RASGRF2 Gene Is Associated with Alcoholic Liver Cirrhosis in Men."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0168685"}], "href": "https://doi.org/10.1371/journal.pone.0168685"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27992614"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27992614"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Timokratis Karamitros, Tara Hurst, Emanuele Marchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human Endogenous Retrovirus-K HML-2 integration within "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "RASGRF2"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " is associated with intravenous drug abuse and modulates transcription in a cell-line model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1811940115"}], "href": "https://doi.org/10.1073/pnas.1811940115"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30249655"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30249655"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Sergio Ruiz, Eugenio Santos, Xosé R Bustelo "}, {"type": "b", "children": [{"type": "t", "text": "RasGRF2, a guanosine nucleotide exchange factor for Ras GTPases, participates in T-cell signaling responses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00912-07"}], "href": "https://doi.org/10.1128/MCB.00912-07"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17923690"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17923690"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Sergio Ruiz, Eugenio Santos, Xosé R Bustelo "}, {"type": "b", "children": [{"type": "t", "text": "The use of knockout mice reveals a synergistic role of the Vav1 and Rasgrf2 gene deficiencies in lymphomagenesis and metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0008229"}], "href": "https://doi.org/10.1371/journal.pone.0008229"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20011522"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20011522"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Fernando Calvo, Victoria Sanz-Moreno, Lorena Agudo-Ibáñez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb2271"}], "href": "https://doi.org/10.1038/ncb2271"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21685891"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21685891"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Xiaojie Ma, Laura Espana-Serrano, Wan-ju Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "βArrestin1 regulates the guanine nucleotide exchange factor RasGRF2 expression and the small GTPase Rac-mediated formation of membrane protrusion and cell motility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.511360"}], "href": "https://doi.org/10.1074/jbc.M113.511360"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24692549"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24692549"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Hong Chen, Makoto Suzuki, Yohko Nakamura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aberrant methylation of RASGRF2 and RASSF1A in human non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2006)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16596198"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16596198"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Peifen Lu, Junjun Chen, Lihong Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RasGRF2 promotes migration and invasion of colorectal cancer cells by modulating expression of MMP9 through Src/Akt/NF-κB pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biol Ther (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384047.2018.1529117"}], "href": "https://doi.org/10.1080/15384047.2018.1529117"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30359168"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30359168"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Olga Y Korolkova, Sarrah E Widatalla, Diva S Whalen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reciprocal expression of Annexin A6 and RasGRF2 discriminates rapidly growing from invasive triple negative breast cancer subsets."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0231711"}], "href": "https://doi.org/10.1371/journal.pone.0231711"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32298357"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32298357"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Qiuling Lin, Moqin Qiu, Xueyan Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variants of SOS2, MAP2K1 and RASGRF2 in the RAS pathway genes predict survival of HBV-related hepatocellular carcinoma patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Toxicol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00204-023-03469-5"}], "href": "https://doi.org/10.1007/s00204-023-03469-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37029817"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37029817"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Gemma Cadby, Sutapa Mukherjee, A W Bill Musk, et al. 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Synonyms	RAS-GRF2
Proteins	RGRF2_HUMAN
NCBI Gene ID	5924
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RASGRF2 has 4,248 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 114 datasets.

Click the + buttons to view associations for RASGRF2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RASGRF2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RASGRF2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of RASGRF2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RASGRF2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RASGRF2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RASGRF2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RASGRF2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RASGRF2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with RASGRF2 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with RASGRF2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RASGRF2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RASGRF2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RASGRF2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RASGRF2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing RASGRF2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RASGRF2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RASGRF2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RASGRF2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RASGRF2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with RASGRF2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with RASGRF2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with RASGRF2 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by RASGRF2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with RASGRF2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with RASGRF2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RASGRF2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RASGRF2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RASGRF2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RASGRF2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RASGRF2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RASGRF2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of RASGRF2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing RASGRF2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with RASGRF2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with RASGRF2 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with RASGRF2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing RASGRF2 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of RASGRF2 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of RASGRF2 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of RASGRF2 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RASGRF2 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.