RASGRP2 Gene

HGNC Family	EF-hand domain containing
Name	RAS guanyl releasing protein 2 (calcium and DAG-regulated)
Description	The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Four alternatively spliced transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRASGRP2, which encodes the calcium‐ and diacylglycerol‐regulated guanine nucleotide exchange factor CalDAG-GEFI, is a pivotal mediator of Rap1 activation that underlies critical “inside-out” signaling in platelets and megakaryocytes. Activation of Rap1 by RASGRP2 drives the conformational change and clustering of integrin αIIbβ3, enhancing fibrinogen binding and platelet aggregation. In patients, pathogenic mutations in RASGRP2 lead to impaired Rap1 activation and integrin signaling, resulting in significant bleeding diatheses, as demonstrated by studies in both megakaryocytes and platelets."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn vascular endothelial cells, RASGRP2 is subject to intricate transcriptional regulation and posttranslational modification. Distinct endothelial splice variants and promoter/silencer elements ensure cell-type–specific expression, while ERK2-dependent phosphorylation of RASGRP2 modulates its catalytic activity and thereby tunes Rap1 signaling. Moreover, RASGRP2 not only reinforces cell–matrix adhesion and barrier integrity by activating Rap1 but also activates related small GTPases (R-RAS and R-RAS2) that protect cells from apoptosis by limiting reactive oxygen species and preserving adherens junctions. These actions support vascular homeostasis and may contribute to the protection against complications such as diabetic retinopathy and atherosclerosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "11"}]}, {"type": "t", "text": "\n\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in hemostasis and vascular integrity, emerging studies show that RASGRP2 contributes to cell migration and adhesion in other contexts. In chronic lymphocytic leukemia cells, for example, CD38-driven increases in intracellular Ca²⁺ stimulate RASGRP2 activity, thereby promoting Rap1-dependent cell adhesion and migration. Additionally, in fibroblast-like synoviocytes from rheumatoid arthritis patients, altered expression of Ras guanine nucleotide-releasing proteins (including RASGRP2) points to potential therapeutic avenues in inflammatory joint disease. Intriguingly, RASGRP2 has also been implicated in host–pathogen interactions, as binding of a herpes simplex virus mutant to RASGRP2 may influence permissiveness to viral infection, and its genetic linkage with other platelet regulatory genes underscores the need for comprehensive assessment of variants in bleeding disorders."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "16"}]}, {"type": "t", "text": "\n\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Koji Eto, Ronan Murphy, Steve W Kerrigan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.202380099"}], "href": "https://doi.org/10.1073/pnas.202380099"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12239348"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12239348"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Matthias Canault, Dorsaf Ghalloussi, Charlotte Grosdidier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20130477"}], "href": "https://doi.org/10.1084/jem.20130477"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24958846"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24958846"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "María Luisa Lozano, Aaron Cook, José María Bastida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel mutations in RASGRP2, which encodes CalDAG-GEFI, abrogate Rap1 activation, causing platelet dysfunction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2015-11-683102"}], "href": "https://doi.org/10.1182/blood-2015-11-683102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27235135"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27235135"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Sarah K Westbury, Matthias Canault, Daniel Greene, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expanded repertoire of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "RASGRP2"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " variants responsible for platelet dysfunction and severe bleeding."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2017-03-776773"}], "href": "https://doi.org/10.1182/blood-2017-03-776773"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28637664"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28637664"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Emilse Bermejo, Maria F Alberto, David S Paul, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Marked bleeding diathesis in patients with platelet dysfunction due to a novel mutation in RASGRP2, encoding CalDAG-GEFI (p.Gly305Asp)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Platelets (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/09537104.2017.1332759"}], "href": "https://doi.org/10.1080/09537104.2017.1332759"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28726538"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28726538"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Kentaro Nagamine, Akira Matsuda, Takamitsu Hori "}, {"type": "b", "children": [{"type": "t", "text": "Identification of the gene regulatory region in human rasgrp2 gene in vascular endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Pharm Bull (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1248/bpb.33.1138"}], "href": "https://doi.org/10.1248/bpb.33.1138"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20606303"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20606303"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jinqi Ren, Aaron A Cook, Wolfgang Bergmeier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A negative-feedback loop regulating ERK1/2 activation and mediated by RasGPR2 phosphorylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2016.04.100"}], "href": "https://doi.org/10.1016/j.bbrc.2016.04.100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27107697"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27107697"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jun-Ichi Takino, Takuma Sato, Takumi Kanetaka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RasGRP2 inhibits glyceraldehyde-derived toxic advanced glycation end-products from inducing permeability in vascular endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-021-82619-0"}], "href": "https://doi.org/10.1038/s41598-021-82619-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33536515"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33536515"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jun-Ichi Takino, Shouhei Miyazaki, Kentaro Nagamine, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Role of RASGRP2 in Vascular Endothelial Cells-A Mini Review."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms222011129"}], "href": "https://doi.org/10.3390/ijms222011129"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34681791"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34681791"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jun-Ichi Takino "}, {"type": "b", "children": [{"type": "t", "text": "[Study on the Role of RASGRP2 in Vascular Endothelial Cells]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Yakugaku Zasshi (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1248/yakushi.23-00113"}], "href": "https://doi.org/10.1248/yakushi.23-00113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37914339"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37914339"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Guozhu Chen, Yisong Pei, Qiaoling Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NEDD4L-mediated RASGRP2 suppresses high-glucose and oxLDL-induced vascular endothelial cell dysfunctions by activating Rap1 and R-Ras."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Mol Cell Res (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2024.119844"}], "href": "https://doi.org/10.1016/j.bbamcr.2024.119844"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39260747"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39260747"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Junichi Takino, Kentaro Nagamine, Takamitsu Hori "}, {"type": "b", "children": [{"type": "t", "text": "Ras guanyl nucleotide releasing protein 2 affects cell viability and cell-matrix adhesion in ECV304 endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Adh Migr (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cam.24082"}], "href": "https://doi.org/10.4161/cam.24082"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23563504"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23563504"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Silvia Mele, Stephen Devereux, Andrea G Pepper, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Calcium-RasGRP2-Rap1 signaling mediates CD38-induced migration of chronic lymphocytic leukemia cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood Adv (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/bloodadvances.2017014506"}], "href": "https://doi.org/10.1182/bloodadvances.2017014506"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29970392"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29970392"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Hiroyuki Nakamura, Sanae Shimamura, Shinsuke Yasuda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ectopic RASGRP2 (CalDAG-GEFI) expression in rheumatoid synovium contributes to the development of destructive arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Rheum Dis (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/annrheumdis-2018-213588"}], "href": "https://doi.org/10.1136/annrheumdis-2018-213588"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30076153"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30076153"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Georgi Manukjan, Verena A Wiegering, Tobias Reindl, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel variants in FERMT3 and RASGRP2-Genetic linkage in Glanzmann-like bleeding disorders."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pediatr Blood Cancer (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pbc.28078"}], "href": "https://doi.org/10.1002/pbc.28078"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31724816"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31724816"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Essa Alharby, Mohammad A Bakhsh, Alia M Albalawi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel missense variant in the "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "RASGRP2"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " gene in patients with moderate to severe bleeding disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Platelets (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/09537104.2019.1663803"}], "href": "https://doi.org/10.1080/09537104.2019.1663803"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32609603"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32609603"}]}]}]}
Synonyms	CALDAG-GEFI
Proteins	GRP2_HUMAN
NCBI Gene ID	10235
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RASGRP2 has 7,774 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 130 datasets.

Click the + buttons to view associations for RASGRP2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RASGRP2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by RASGRP2 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RASGRP2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of RASGRP2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of RASGRP2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of RASGRP2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RASGRP2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RASGRP2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RASGRP2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RASGRP2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RASGRP2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of RASGRP2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RASGRP2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of RASGRP2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with RASGRP2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RASGRP2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RASGRP2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RASGRP2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with RASGRP2 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with RASGRP2 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of RASGRP2 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RASGRP2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RASGRP2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing RASGRP2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RASGRP2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RASGRP2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RASGRP2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RASGRP2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with RASGRP2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with RASGRP2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with RASGRP2 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of RASGRP2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by RASGRP2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with RASGRP2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RASGRP2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RASGRP2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RASGRP2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RASGRP2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RASGRP2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RASGRP2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of RASGRP2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.