{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRASSF2 is emerging as a critical Ras‐effector protein that exerts tumor‐suppressive functions. It directly binds activated K‐Ras to mediate proapoptotic and cell cycle–inhibitory signals, thereby counteracting the oncogenic potential of aberrant Ras signalling. In various tumor types, re‐expression of RASSF2 leads to growth suppression and enhanced apoptosis, underscoring its role as a bona fide tumor suppressor. Notably, experimental studies have demonstrated that forced expression of RASSF2 inhibits tumor cell growth and transformation in vitro and in in vivo models."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nA salient feature of RASSF2 inactivation in cancer is its frequent epigenetic silencing via promoter hypermethylation. In a range of malignancies—notably colorectal, gastric, breast, lung, cervical, ovarian, and even esophageal cancers—the RASSF2 promoter exhibits tumor‐specific hypermethylation that correlates with loss of gene expression. These epigenetic modifications not only occur early during tumorigenesis but also serve as potential diagnostic markers, as demonstrated by studies using primary tumor tissues, matched normal epithelium, and even circulating plasma DNA."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its expression status, RASSF2 operates within complex signaling networks. It interacts with proapoptotic kinases such as MST1 and MST2 and appears to protect these kinases from degradation, thereby fostering an apoptotic environment. In addition, its subcellular distribution, governed by functional nuclear localization and export signals, is modulated by kinase activity (for example, via ERK2‐mediated phosphorylation) and transcriptional co‐activators like p300. Such regulatory mechanisms integrate RASSF2 into broader pathways that include the Hippo cascade and influence nuclear–cytoplasmic dynamics essential for cell growth control."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "19", "end_ref": "21"}, {"type": "fg_f", "ref": "5"}, {"type": "fg_f", "ref": "22"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRecent investigations have also uncovered layers of post‐transcriptional regulation involving RASSF2. For instance, a circular RNA derived from RASSF2 (circRASSF2) has been shown to be up‐regulated in laryngeal squamous cell carcinoma, where it modulates tumor cell behavior by acting as a molecular sponge for specific microRNAs. Similarly, in the tumor microenvironment of head and neck cancers, microRNA‐mediated downregulation of the RASSF2–PAR‐4 axis in cancer‐associated fibroblasts appears to promote cancer cell proliferation and migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "23"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, these studies also indicate that the status of RASSF2—whether by genetic, epigenetic, or post‐transcriptional alterations—bears significant prognostic and diagnostic value. Aberrant methylation and/or loss of RASSF2 expression correlates with adverse clinical features and survival outcomes in cancers such as colorectal, thyroid, and ovarian, as well as in pancreatic, cervical, and even breast cancers. Such findings underscore the promise of incorporating RASSF2 profiling into liquid biopsy panels and other molecular screening approaches for early cancer detection and prognostication."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "25", "end_ref": "30"}, {"type": "fg_f", "ref": "15"}, {"type": "fg_fs", "start_ref": "31", "end_ref": "34"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its roles in tumor cell–intrinsic pathways, genetic variants in RASSF2 may further modify cancer risk and phenotype. For example, a particular single nucleotide polymorphism (rs4813720) in RASSF2 has been linked to sex‐specific differences in childhood acute lymphoblastic leukemia, suggesting that interindividual genetic variability in RASSF2 can modulate responses to oncogenic signals."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "35"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Michele D Vos, Chad A Ellis, Candice Elam, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Inactivation of RASSF2A by promoter methylation correlates with lymph node metastasis in nasopharyngeal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.22185"}], "href": "https://doi.org/10.1002/ijc.22185"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17013896"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17013896"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Kyoichi Kaira, Noriaki Sunaga, Yoshio Tomizawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic inactivation of the RAS-effector gene RASSF2 in lung cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2007)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17549418"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17549418"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Takashi Imai, Minoru Toyota, Hiromu Suzuki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1349-7006.2008.00769.x"}], "href": "https://doi.org/10.1111/j.1349-7006.2008.00769.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18294275"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18294275"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Howard Donninger, Luke Hesson, Michele Vos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Ras effector RASSF2 controls the PAR-4 tumor suppressor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00208-09"}], "href": "https://doi.org/10.1128/MCB.00208-09"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20368356"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20368356"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Samuel A Stoner, Katherine Tin Heng Liu, Elizabeth T Andrews, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The RUNX1-ETO target gene RASSF2 suppresses t(8;21) AML development and regulates Rac GTPase signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood Cancer J (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41408-020-0282-9"}], "href": "https://doi.org/10.1038/s41408-020-0282-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32029705"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32029705"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Luke B Hesson, Robin Wilson, Dion Morton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1208566"}], "href": "https://doi.org/10.1038/sj.onc.1208566"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15806169"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15806169"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "M Endoh, G Tamura, T Honda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RASSF2, a potential tumour suppressor, is silenced by CpG island hypermethylation in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Cancer (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.bjc.6602854"}], "href": "https://doi.org/10.1038/sj.bjc.6602854"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16265349"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16265349"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Hye-Won Park, Hio Chung Kang, Il-Jin Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Correlation between hypermethylation of the RASSF2A promoter and K-ras/BRAF mutations in microsatellite-stable colorectal cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.22276"}], "href": "https://doi.org/10.1002/ijc.22276"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17013898"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17013898"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "W N Cooper, R E Dickinson, A Dallol, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic regulation of the ras effector/tumour suppressor RASSF2 in breast and lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1210805"}], "href": "https://doi.org/10.1038/sj.onc.1210805"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17891178"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17891178"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jinghua Ren, Wenshan He, Ruiguang Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RASSF2A promoter methylation in hepatitis B virus-related hepatocellular carcinogenesis and its correlation with elevated serum alpha-fetoprotein level."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Huazhong Univ Sci Technolog Med Sci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11596-009-0309-8"}], "href": "https://doi.org/10.1007/s11596-009-0309-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19513612"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19513612"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Seley Gharanei, Anna T Brini, Sumathi Vaiyapuri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RASSF2 methylation is a strong prognostic marker in younger age patients with Ewing sarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Epigenetics (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/epi.25617"}], "href": "https://doi.org/10.4161/epi.25617"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23887284"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23887284"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Xian Zhang, Yingchun Ma, Yu Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aberrant promoter methylation and silencing of RASSF2A gene in cervical cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Obstet Gynaecol Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jog.12322"}], "href": "https://doi.org/10.1111/jog.12322"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24605823"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24605823"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Yu Wu, Xian Zhang, Li Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aberrant methylation of RASSF2A in tumors and plasma of patients with epithelial ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian Pac J Cancer Prev (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7314/apjcp.2014.15.3.1171"}], "href": "https://doi.org/10.7314/apjcp.2014.15.3.1171"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24606436"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24606436"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Noemi Perez-Janices, Idoia Blanco-Luquin, Natalia Torrea, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential involvement of RASSF2 hypermethylation in breast cancer subtypes and their prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.4062"}], "href": "https://doi.org/10.18632/oncotarget.4062"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26284587"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26284587"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Wei Guo, Zhiming Dong, Yanli Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased expression and frequent promoter hypermethylation of RASSF2 and RASSF6 correlate with malignant progression and poor prognosis of gastric cardia adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Carcinog (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mc.22416"}], "href": "https://doi.org/10.1002/mc.22416"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26456015"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26456015"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "D Aydin, A Bilici, S Kayahan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic importance of RASSF2 expression in patients with gastric cancer who had undergone radical gastrectomy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Transl Oncol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12094-015-1405-9"}], "href": "https://doi.org/10.1007/s12094-015-1405-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26459248"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26459248"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Kena Zhou, Congbo Cai, Yi He, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "RASSF2 associates with and stabilizes the proapoptotic kinase MST2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2009.152"}], "href": "https://doi.org/10.1038/onc.2009.152"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19525978"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19525978"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Gita Kumari, S Mahalingam "}, {"type": "b", "children": [{"type": "t", "text": "Extracellular signal-regulated kinase 2 (ERK-2) mediated phosphorylation regulates nucleo-cytoplasmic shuttling and cell growth control of Ras-associated tumor suppressor protein, RASSF2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2009.06.013"}], "href": "https://doi.org/10.1016/j.yexcr.2009.06.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19555684"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19555684"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Hoogeun Song, Sangphil Oh, Hyun Jung Oh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2009.11.175"}], "href": "https://doi.org/10.1016/j.bbrc.2009.11.175"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19962960"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19962960"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Chungang Liu, Yunhui Pan, Xiuli Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of RASSF2A by p300 induces late apoptosis through histone hyperacetylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biol Int (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/CBI20090388"}], "href": "https://doi.org/10.1042/CBI20090388"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20716062"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20716062"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Zongze Shen, Xing Qin, Ming Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cancer-associated fibroblasts promote cancer cell growth through a miR-7-RASSF2-PAR-4 axis in the tumor microenvironment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.13609"}], "href": "https://doi.org/10.18632/oncotarget.13609"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27901488"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27901488"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Linli Tian, Jing Cao, Hui Jiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircRASSF2 promotes laryngeal squamous cell carcinoma progression by regulating the miR-302b-3p/IGF-1R axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Sci (Lond) (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/CS20190110"}], "href": "https://doi.org/10.1042/CS20190110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30992382"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30992382"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Kimishige Akino, Minoru Toyota, Hiromu Suzuki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.gastro.2005.03.051"}], "href": "https://doi.org/10.1053/j.gastro.2005.03.051"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16012945"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16012945"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Bo Bin Lee, Eun Ju Lee, Eun Hyun Jung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aberrant methylation of APC, MGMT, RASSF2A, and Wif-1 genes in plasma as a biomarker for early detection of colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-09-0111"}], "href": "https://doi.org/10.1158/1078-0432.CCR-09-0111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19773381"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19773381"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Undraga Schagdarsurengin, Antje M Richter, Juliane Hornung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Frequent epigenetic inactivation of RASSF2 in thyroid cancer and functional consequences."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1476-4598-9-264"}], "href": "https://doi.org/10.1186/1476-4598-9-264"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20920251"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20920251"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Masatsugu Hiraki, Yoshihiko Kitajima, Yasuo Koga, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aberrant gene methylation is a biomarker for the detection of cancer cells in peritoneal wash samples from advanced gastric cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Surg Oncol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1245/s10434-011-1636-0"}], "href": "https://doi.org/10.1245/s10434-011-1636-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21409489"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21409489"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Ling Zhao, Quancai Cui, Zhaohui Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aberrant methylation of RASSF2A in human pancreatic ductal adenocarcinoma and its relation to clinicopathologic features."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pancreas (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MPA.0b013e318223d1a5"}], "href": "https://doi.org/10.1097/MPA.0b013e318223d1a5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21792082"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21792082"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "N Perez-Janices, I Blanco-Luquin, M T Tuñón, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EPB41L3, TSP-1 and RASSF2 as new clinically relevant prognostic biomarkers in diffuse gliomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.2745"}], "href": "https://doi.org/10.18632/oncotarget.2745"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25621889"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25621889"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Wei Guo, Zhiming Dong, Jianli Cui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aberrant hypermethylation of RASSF2 in tumors and peripheral blood DNA as a biomarker for malignant progression and poor prognosis of esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Metastasis (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10585-015-9759-5"}], "href": "https://doi.org/10.1007/s10585-015-9759-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26482475"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26482475"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Y Xia, N Xiong, Y Huang "}, {"type": "b", "children": [{"type": "t", "text": "Relationship between methylation status of RASSF2A gene promoter and endometriosis-associated ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Regul Homeost Agents (2018)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29504361"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29504361"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Zongwei Liu, Guilin Feng, Yonghui Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hyperhomocysteinemia may aggravate abdominal aortic aneurysm formation by up-regulating RASSF2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2023.148036"}], "href": "https://doi.org/10.1016/j.gene.2023.148036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38036076"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38036076"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Emre Aykanli, Serdar Arisan, Elif Damla Arisan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Diagnostic Value of GSTP1, RASSF1, AND RASSF2 Methylation in Serum of Prostate Cancer Patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Urol J (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.22037/uj.v20i.8014"}], "href": "https://doi.org/10.22037/uj.v20i.8014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38493315"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38493315"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Sandeep K Singh, Philip J Lupo, Michael E Scheurer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A childhood acute lymphoblastic leukemia genome-wide association study identifies novel sex-specific risk variants."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Medicine (Baltimore) (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MD.0000000000005300"}], "href": "https://doi.org/10.1097/MD.0000000000005300"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27861356"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27861356"}]}]}]}