{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRASSF6, a member of the Ras association domain family, plays a pivotal tumor‐suppressive role by modulating apoptosis and the cell cycle. Early studies demonstrated that RASSF6 binds activated Ras and, in cooperation with oncogenic Ras, promotes apoptosis in tumor cells, while its expression is frequently lost in human cancers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Subsequent work revealed that RASSF6 interacts with MST2 in the Hippo pathway—inhibiting MST2 activity when bound but, once released from MST2, triggering WW45‐dependent apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In HeLa cells, exogenous RASSF6 expression induced cell death via both caspase‐dependent and caspase‐independent mechanisms through Bax activation and cytochrome c release."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, in p53‐positive cells RASSF6 facilitates the ubiquitination and degradation of MDM2 to stabilize p53 and induce G1/S arrest"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", while in p53‐negative contexts it can engage pRb‐dependent pathways to similarly promote cell cycle arrest and apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " DNA damage further triggers the nuclear accumulation of RASSF6 through phosphorylation‐dependent interactions with chromatin remodelers, enhancing p53 target gene transcription"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", and its binding with BCL‑XL has been shown to counteract these apoptotic signals."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMultiple investigations have highlighted that the tumor‐suppressive functions of RASSF6 are frequently compromised by epigenetic mechanisms. In gastric cancer, for example, miR‑181a‑5p directly targets and represses RASSF6, thereby enhancing cell proliferation, colony formation, and epithelial–mesenchymal transition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Similarly, in colorectal cancer, miR‑496 acts as an oncomiR by binding directly to RASSF6, leading to Wnt pathway activation and increased metastatic potential."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Aberrant promoter CpG island methylation has been detected for RASSF6 in gastric carcinoma, with methylation events correlating inversely with its expression"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "and extended analyses in acute lymphocytic leukemia have shown that RASSF6, along with other family members, is epigenetically silenced"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " In addition, genome-wide methylation studies in neuroblastoma and other solid tumors have implicated RASSF family inactivation as a frequent event."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFunctional studies across various tumor types further corroborate a critical role for RASSF6 in restraining malignant progression. In melanoma, re-expression of RASSF6 suppresses MAPK and AKT pathway activation, reduces cell invasiveness, and limits brain metastasis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": " In colorectal and breast cancers, restoration of RASSF6 expression curtails cellular proliferation, migration, and colony formation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": " In clear cell renal cell carcinoma, RASSF6 induces p21 accumulation and G1 arrest, and it promotes apoptosis via activated JNK signaling"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": ", while in nasopharyngeal carcinoma, RASSF6 overexpression sensitizes metastatic cells to cisplatin and radiation through enhanced JNK‐mediated apoptotic responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": " In hepatocellular carcinoma, RASSF6 dampens focal adhesion kinase phosphorylation and reduces MMP‑2/9 expression, thereby inhibiting invasion and the epithelial–mesenchymal transition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": " Moreover, decreased RASSF6 expression has been associated with adverse prognosis in gastric"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": "and pancreatic ductal adenocarcinomas"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "22"}]}, {"type": "t", "text": ", whereas in esophageal squamous cell carcinoma, elevated RASSF6 is paradoxically linked to lymph node metastasis and poor survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "23"}]}, {"type": "t", "text": " In osteosarcoma, the tumor-suppressive long noncoding RNA TUSC7 exerts its function by sponging miR‑181a and thereby relieving repression on RASSF6, underscoring the therapeutic potential of the TUSC7/miR‑181a/RASSF6 axis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "24"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "N P C Allen, H Donninger, M D Vos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RASSF6 is a novel member of the RASSF family of tumor suppressors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1210440"}], "href": "https://doi.org/10.1038/sj.onc.1210440"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17404571"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17404571"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mitsunobu Ikeda, Akira Kawata, Misa Nishikawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hippo pathway-dependent and -independent roles of RASSF6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.2000300"}], "href": "https://doi.org/10.1126/scisignal.2000300"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19797269"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19797269"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Mitsunobu Ikeda, Susumu Hirabayashi, Naoyuki Fujiwara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ras-association domain family protein 6 induces apoptosis via both caspase-dependent and caspase-independent pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2007.02.013"}], "href": "https://doi.org/10.1016/j.yexcr.2007.02.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17367779"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17367779"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hiroaki Iwasa, Takumi Kudo, Sainawaer Maimaiti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The RASSF6 tumor suppressor protein regulates apoptosis and the cell cycle via MDM2 protein and p53 protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.507384"}], "href": "https://doi.org/10.1074/jbc.M113.507384"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24003224"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24003224"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Shakhawoat Hossain, Hiroaki Iwasa, Aradhan Sarkar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The RASSF6 Tumor Suppressor Protein Regulates Apoptosis and Cell Cycle Progression via Retinoblastoma Protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00046-18"}], "href": "https://doi.org/10.1128/MCB.00046-18"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29891515"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29891515"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Joshua Agbemefa Kuleape, Shakhawoat Hossain, Caleb Kwame Sinclear, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNA Damage Triggers the Nuclear Accumulation of RASSF6 Tumor Suppressor Protein via CDK9 and BAF53 To Regulate p53 Target Gene Transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00310-21"}], "href": "https://doi.org/10.1128/MCB.00310-21"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34898277"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34898277"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Xiaoyin Xu, Hiroaki Iwasa, Shakhawoat Hossain, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BCL-XL binds and antagonizes RASSF6 tumor suppressor to suppress p53 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Cells (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/gtc.12541"}], "href": "https://doi.org/10.1111/gtc.12541"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29193479"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29193479"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yushuai Mi, Dongyuan Zhang, Weiliang Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-181a-5p promotes the progression of gastric cancer via RASSF6-mediated MAPK signalling activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2016.12.033"}], "href": "https://doi.org/10.1016/j.canlet.2016.12.033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28043911"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28043911"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Hua Wang, Bianbian Yan, Pan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-496 promotes migration and epithelial-mesenchymal transition by targeting RASSF6 in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.29066"}], "href": "https://doi.org/10.1002/jcp.29066"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31273789"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31273789"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Wei Guo, Zhiming Dong, Yanli Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased expression and frequent promoter hypermethylation of RASSF2 and RASSF6 correlate with malignant progression and poor prognosis of gastric cardia adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Carcinog (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mc.22416"}], "href": "https://doi.org/10.1002/mc.22416"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26456015"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26456015"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Samareh Younesian, Sepideh Shahkarami, Parisa Ghaffari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Residual methylation of tumor suppressor gene promoters, RASSF6 and RASSF10, as novel biomarkers for minimal residual disease detection in adult acute lymphoblastic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Hematol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00277-019-03775-y"}], "href": "https://doi.org/10.1007/s00277-019-03775-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31486880"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31486880"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Anna Djos, Tommy Martinsson, Per Kogner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The RASSF gene family members RASSF5, RASSF6 and RASSF7 show frequent DNA methylation in neuroblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1476-4598-11-40"}], "href": "https://doi.org/10.1186/1476-4598-11-40"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22695170"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22695170"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Samareh Younesian, Sepideh Shahkarami, Parisa Ghaffari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNA hypermethylation of tumor suppressor genes RASSF6 and RASSF10 as independent prognostic factors in adult acute lymphoblastic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leuk Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.leukres.2017.08.016"}], "href": "https://doi.org/10.1016/j.leukres.2017.08.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28869817"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28869817"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Jessica J Mezzanotte, Victoria Hill, M Lee Schmidt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RASSF6 exhibits promoter hypermethylation in metastatic melanoma and inhibits invasion in melanoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Epigenetics (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/15592294.2014.983361"}], "href": "https://doi.org/10.4161/15592294.2014.983361"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25482183"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25482183"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Onder Bozdogan, Servet Guresci, Devrim Öcalan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Kindlin-3 and RASSF6 are probable biomarkers for predicting metastasis in cutaneous melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pol J Pathol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.5114/pjp.2021.111774"}], "href": "https://doi.org/10.5114/pjp.2021.111774"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35048636"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35048636"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Erfei Chen, Fangfang Yang, Hongjuan He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased level of RASSF6 in sporadic colorectal cancer and its anti-tumor effects both in vitro and in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.7852"}], "href": "https://doi.org/10.18632/oncotarget.7852"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27009808"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27009808"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Zheng He, Ting-Ting Zhao, Feng Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of RASSF6 promotes breast cancer growth and chemoresistance through regulation of Hippo signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.06.159"}], "href": "https://doi.org/10.1016/j.bbrc.2018.06.159"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29964010"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29964010"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Ying-Ying Liang, Li-Sheng Zheng, Yuan-Zhong Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RASSF6 promotes p21(Cip1/Waf1)-dependent cell cycle arrest and apoptosis through activation of the JNK/SAPK pathway in clear cell renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cc.28416"}], "href": "https://doi.org/10.4161/cc.28416"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24626183"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24626183"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Ying-Ying Liang, Ming-Yuan Chen, Yi-Jun Hua, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of Ras association domain family member 6 (RASSF6) underlies the treatment resistance of highly metastatic nasopharyngeal carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0100843"}], "href": "https://doi.org/10.1371/journal.pone.0100843"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25028967"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25028967"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Nan Zhu, Mahui Si, Ning Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of RAS-Association Domain Family 6 (RASSF6) Inhibits Proliferation and Tumorigenesis in Hepatocellular Carcinoma Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3727/096504016X14796039599926"}], "href": "https://doi.org/10.3727/096504016X14796039599926"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27983932"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27983932"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Yugang Wen, Quan Wang, Chongzhi Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased expression of RASSF6 is a novel independent prognostic marker of a worse outcome in gastric cancer patients after curative surgery."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Surg Oncol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1245/s10434-011-1668-5"}], "href": "https://doi.org/10.1245/s10434-011-1668-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21442347"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21442347"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Hui-Lin Ye, Dou-Dou Li, Qing Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Low RASSF6 expression in pancreatic ductal adenocarcinoma is associated with poor survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Gastroenterol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3748/wjg.v21.i21.6621"}], "href": "https://doi.org/10.3748/wjg.v21.i21.6621"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26074700"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26074700"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Leilei Zheng, Zitong Zhao, Lulu Rong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RASSF6-TRIM16 axis promotes cell proliferation, migration and invasion in esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Genet Genomics (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jgg.2019.10.004"}], "href": "https://doi.org/10.1016/j.jgg.2019.10.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31812473"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31812473"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Aiqing Zhao, Wanlin Liu, Xiaolong Cui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA TUSC7 inhibits osteosarcoma progression through the miR‑181a/RASSF6 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm.2020.4825"}], "href": "https://doi.org/10.3892/ijmm.2020.4825"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33416181"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33416181"}]}]}]}