RBBP6 Gene

Name	retinoblastoma binding protein 6
Description	The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that RBBP6 functions as a multifunctional regulator of RNA metabolism. Notably, its involvement in the 3′ end processing of pre-mRNAs is mediated by an unusual ubiquitin‐like domain (DWNN) that associates with the core polyadenylation machinery, ensuring proper cleavage and polyadenylation of mRNAs—especially those with AU‐rich 3′ untranslated regions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, a study on Ebola virus infection demonstrated that a 23–amino acid region of RBBP6 binds the viral transcription regulator VP30 by mimicking the binding interface of the viral nucleoprotein. This interaction inhibits viral transcription, highlighting the therapeutic potential of targeting this interface."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond RNA processing, RBBP6 exerts significant control over cell proliferation, apoptosis, and cell cycle progression in various cancers. As an E3 ubiquitin ligase, RBBP6 ubiquitinates substrates such as YB‐1 and the transcriptional repressor ZBTB38—events that ultimately modulate p53 stability and thereby promote cell proliferation. In esophageal, lung, breast, colorectal, cervical, ovarian, prostate, and even glioma contexts, RBBP6 overexpression or dysregulation has been linked to enhanced tumor cell viability, migration, invasion, and metastasis, while its inhibition (via RNA interference) augments apoptosis and induces cell cycle arrest. In several studies, RBBP6 knockdown restored p53 functions and reduced oncogenic signaling pathways (including those mediated by the JNK pathway and NF‑κB activation), underscoring its potential as a diagnostic biomarker and therapeutic target."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nStructural analyses have further refined the mechanistic understanding of RBBP6. Its C‐terminal region contains a RING finger–like domain that, despite binding two zinc ions, structurally resembles U‑box proteins—suggesting a role in chaperone-mediated ubiquitination and protein quality control via interactions with Hsp70 and Hsp40. Moreover, in the context of HIV-associated nephropathy, increased expression of the DWNN-only isoform of RBBP6 has been correlated with enhanced apoptosis, further emphasizing the complexity of its regulatory functions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jyoti Batra, Judd F Hultquist, Dandan Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein Interaction Mapping Identifies RBBP6 as a Negative Regulator of Ebola Virus Replication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2018.08.044"}], "href": "https://doi.org/10.1016/j.cell.2018.08.044"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30550789"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30550789"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Dafne Campigli Di Giammartino, Wencheng Li, Koichi Ogami, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RBBP6 isoforms regulate the human polyadenylation machinery and modulate expression of mRNAs with AU-rich 3' UTRs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.245787.114"}], "href": "https://doi.org/10.1101/gad.245787.114"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25319826"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25319826"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Vytaute Boreikaite, Thomas S Elliott, Jason W Chin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RBBP6 activates the pre-mRNA 3' end processing machinery in humans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.349223.121"}], "href": "https://doi.org/10.1101/gad.349223.121"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35177536"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35177536"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Moredreck Chibi, Mervin Meyer, Amanda Skepu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2008.09.060"}], "href": "https://doi.org/10.1016/j.jmb.2008.09.060"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18851979"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18851979"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Benoit Miotto, Moredreck Chibi, Ping Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The RBBP6/ZBTB38/MCM10 axis regulates DNA replication and common fragile site stability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2014.03.030"}], "href": "https://doi.org/10.1016/j.celrep.2014.03.030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24726359"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24726359"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "David J R Pugh, Eiso Ab, Andrew Faro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DWNN, a novel ubiquitin-like domain, implicates RBBP6 in mRNA processing and ubiquitin-like pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Struct Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1472-6807-6-1"}], "href": "https://doi.org/10.1186/1472-6807-6-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16396680"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16396680"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Lesetja R Motadi, Kanti D Bhoola, Zodwa Dlamini "}, {"type": "b", "children": [{"type": "t", "text": "Expression and function of retinoblastoma binding protein 6 (RBBP6) in human lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunobiology (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.imbio.2011.05.004"}], "href": "https://doi.org/10.1016/j.imbio.2011.05.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21676486"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21676486"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Pontsho Moela, Mpho M S Choene, Lesetja R Motadi "}, {"type": "b", "children": [{"type": "t", "text": "Silencing RBBP6 (Retinoblastoma Binding Protein 6) sensitises breast cancer cells MCF7 to staurosporine and camptothecin-induced cell death."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunobiology (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.imbio.2014.03.002"}], "href": "https://doi.org/10.1016/j.imbio.2014.03.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24703106"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24703106"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Zukile Mbita, Mervin Meyer, Amanda Skepu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "De-regulation of the RBBP6 isoform 3/DWNN in human cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-011-1150-5"}], "href": "https://doi.org/10.1007/s11010-011-1150-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22139301"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22139301"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Chao Xiao, Gang Wu, Zhijie Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RBBP6, a RING finger-domain E3 ubiquitin ligase, induces epithelial-mesenchymal transition and promotes metastasis of colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-019-2070-7"}], "href": "https://doi.org/10.1038/s41419-019-2070-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31685801"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31685801"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Chao Xiao, Yupeng Wang, Miao Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RBBP6 increases radioresistance and serves as a therapeutic target for preoperative radiotherapy in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.13516"}], "href": "https://doi.org/10.1111/cas.13516"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29369481"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29369481"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Mautin A Kappo, Eiso Ab, Faqeer Hassem, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Solution structure of RING finger-like domain of retinoblastoma-binding protein-6 (RBBP6) suggests it functions as a U-box."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.217059"}], "href": "https://doi.org/10.1074/jbc.M110.217059"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22130672"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22130672"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Fang Teng, Hong-Jie Ruan, Juan Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RBBP6 promotes human cervical carcinoma malignancy via JNK signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2018.02.083"}], "href": "https://doi.org/10.1016/j.biopha.2018.02.083"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29501043"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29501043"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Zodwa Dlamini, Charleen Rupnarain, Sarala Naicker, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression analysis and association of RBBP6 with apoptosis in colon cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Histol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10735-016-9663-6"}], "href": "https://doi.org/10.1007/s10735-016-9663-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26905308"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26905308"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Wen Zhang, Jianguo Shi, Guoyan Liu "}, {"type": "b", "children": [{"type": "t", "text": "Abnormal expression of long non-coding RNA FGD5-AS1 affects the development of ovarian cancer through regulating miR-107/RBBP6 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Chin J Physiol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4103/cjop.CJOP-D-22-00084"}], "href": "https://doi.org/10.4103/cjop.CJOP-D-22-00084"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37322627"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37322627"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Dezhi Hu, Shuo Zhang, Yingjie Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of genetic variants in the retinoblastoma binding protein 6 gene with the risk of glioma: a case-control study in a Chinese Han population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosurg (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3171/2014.6.JNS132240"}], "href": "https://doi.org/10.3171/2014.6.JNS132240"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25127414"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25127414"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Y-J Liu, L-L Cui, Z-S Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RBBP6 aggravates the progression of ovarian cancer by targeting PIK3R6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202010_23386"}], "href": "https://doi.org/10.26355/eurrev_202010_23386"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33155192"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33155192"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Wen-Ying Guan, Sheng Zhao, Yun-Na Luo "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of the expression and association of retinoblastoma binding protein 6 with the JNK signaling pathway in prostate cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biol Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cbin.11419"}], "href": "https://doi.org/10.1002/cbin.11419"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32662898"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32662898"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Robert E Scott, Erica White-Grindley, H Earl Ruley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "P2P-R expression is genetically coregulated with components of the translation machinery and with PUM2, a translational repressor that associates with the P2P-R mRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.20263"}], "href": "https://doi.org/10.1002/jcp.20263"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15617101"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15617101"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Zukile Mbita, Sarala Naicker, Stewart Goetsch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The association of RBBP6 variant 3 expressions with apoptosis in human immunodeficiency virus-associated nephropathy (HIVAN)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Mol Pathol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexmp.2015.04.005"}], "href": "https://doi.org/10.1016/j.yexmp.2015.04.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25910411"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25910411"}]}]}]}
Synonyms	MY038, P2P-R, SNAMA, RBQ-1
Proteins	RBBP6_HUMAN
NCBI Gene ID	5930
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RBBP6 has 8,213 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 127 datasets.

Click the + buttons to view associations for RBBP6 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RBBP6 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by RBBP6 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RBBP6 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of RBBP6 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of RBBP6 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of RBBP6 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RBBP6 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RBBP6 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RBBP6 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RBBP6 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RBBP6 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of RBBP6 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RBBP6 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of RBBP6 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with RBBP6 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with RBBP6 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RBBP6 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RBBP6 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RBBP6 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of RBBP6 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing RBBP6 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RBBP6 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RBBP6 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing RBBP6 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing RBBP6 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing RBBP6 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RBBP6 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RBBP6 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RBBP6 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RBBP6 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with RBBP6 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of RBBP6 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with RBBP6 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RBBP6 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RBBP6 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RBBP6 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RBBP6 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RBBP6 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RBBP6 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of RBBP6 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing RBBP6 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.