RBL2 Gene

Name	retinoblastoma-like 2
Description	Enables promoter-specific chromatin binding activity. Involved in regulation of lipid kinase activity. Acts upstream of or within negative regulation of gene expression. Located in chromosome; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRBL2 (p130) is a key member of the retinoblastoma protein family that helps enforce cell‐cycle arrest and maintain cellular quiescence by repressing E2F‐responsive genes. RBL2/p130 contributes to transcriptional repression as part of multiprotein complexes (for example, the DREAM complex), and its activity is tightly controlled by phosphorylation. Cyclin-dependent kinases, such as those activated in mid‐G1, phosphorylate p130—modifying its ability to bind E2F—while specific phosphatases including PP2A dephosphorylate it to enhance its stability, thus ensuring proper cell cycle progression and exit (see, e.g.."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to mediating cell cycle arrest, RBL2/p130 functions as an important tumor suppressor and regulator of senescence and differentiation. Its maintenance of a repressive state on genes required for S‐phase entry makes it a critical barrier to oncogenic transformation. Alterations in p130 stability or function—for example, through enhanced proteolysis after CDK4/6 phosphorylation or via disruption by viral oncoproteins from high‐risk human papillomaviruses, Kaposi’s sarcoma–associated herpesvirus, or cytomegalovirus—can promote unscheduled cell cycle reentry and contribute to tumor progression in various cancers including small‐cell lung carcinoma, breast cancer, hepatocellular carcinoma, and osteosarcoma. Moreover, p130 is implicated in the cellular response to DNA damage where its recruitment and complex formation (with E2F factors) potentiate an enduring senescence‐like arrest, and its targeting by microRNAs (for instance, miR‑106b) further illustrates its role in oncogenesis (see, e.g.."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "18"}, {"type": "fg_f", "ref": "9"}, {"type": "fg_f", "ref": "13"}, {"type": "fg_f", "ref": "15"}, {"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional layers of regulation modulate RBL2/p130 function. Epigenetic mechanisms—including histone modifications and DNA methylation—as well as microRNA‐mediated targeting (for example, by the miR‑106b cluster), further adjust the protein’s expression and activity, thereby influencing differentiation programs and stress responses. Viral proteins such as SV40 large T antigen and the HCMV UL97 kinase additionally impact p130 through altered phosphorylation dynamics that affect its promoter association and degradation. Collectively, these modifications underscore the critical and multifaceted role of RBL2/p130 in balancing proliferation, differentiation, and apoptosis in both normal and transformed cells (see, e.g.."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}, {"type": "fg_f", "ref": "6"}, {"type": "fg_f", "ref": "14"}, {"type": "fg_fs", "start_ref": "22", "end_ref": "24"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Larisa Litovchick, Subhashini Sadasivam, Laurence Florens, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2007.04.015"}], "href": "https://doi.org/10.1016/j.molcel.2007.04.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17531812"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17531812"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Donato Tedesco, Jiri Lukas, Steven I Reed "}, {"type": "b", "children": [{"type": "t", "text": "The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.1011202"}], "href": "https://doi.org/10.1101/gad.1011202"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12435635"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12435635"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Elizaveta V Benevolenskaya, Heather L Murray, Philip Branton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Binding of pRB to the PHD protein RBP2 promotes cellular differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2005.05.012"}], "href": "https://doi.org/10.1016/j.molcel.2005.05.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15949438"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15949438"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Lucia Cicchillitti, Pasquale Fasanaro, Paolo Biglioli, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Distinct phosphorylation events regulate p130- and p107-mediated repression of E2F-4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M200381200"}], "href": "https://doi.org/10.1074/jbc.M200381200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12006580"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12006580"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Giuseppina D'Andrilli, Valeria Masciullo, Luigi Bagella, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Frequent loss of pRb2/p130 in human ovarian carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.ccr-03-0524"}], "href": "https://doi.org/10.1158/1078-0432.ccr-03-0524"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15131049"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15131049"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Bethany E Schaffer, Kwon-Sik Park, Gloria Yiu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of p130 accelerates tumor development in a mouse model for human small-cell lung carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-09-4228"}], "href": "https://doi.org/10.1158/0008-5472.CAN-09-4228"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20406986"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20406986"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Fang Lu, William Stedman, Malik Yousef, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic regulation of Kaposi's sarcoma-associated herpesvirus latency by virus-encoded microRNAs that target Rta and the cellular Rbl2-DNMT pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.01997-09"}], "href": "https://doi.org/10.1128/JVI.01997-09"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20071580"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20071580"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Marcella Macaluso, Caterina Cinti, Giuseppe Russo, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "p130/p107/p105Rb-dependent transcriptional repression during DNA-damage-induced cell-cycle exit at G2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.02307"}], "href": "https://doi.org/10.1242/jcs.02307"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15827088"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15827088"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Thanh U Barbie, David A Barbie, David T MacLaughlin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mullerian Inhibiting Substance inhibits cervical cancer cell growth via a pathway involving p130 and p107."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.2636900100"}], "href": "https://doi.org/10.1073/pnas.2636900100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14671316"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14671316"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Nicholas J Genovese, N Sanjib Banerjee, Thomas R Broker, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Casein kinase II motif-dependent phosphorylation of human papillomavirus E7 protein promotes p130 degradation and S-phase induction in differentiated human keratinocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.01202-07"}], "href": "https://doi.org/10.1128/JVI.01202-07"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18321970"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18321970"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Nicola Alessio, Wolfgang Bohn, Verena Rauchberger, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "pRb2/p130, vascular endothelial growth factor, p27(KIP1), and proliferating cell nuclear antigen expression in hepatocellular carcinoma: their clinical significance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-03-0662"}], "href": "https://doi.org/10.1158/1078-0432.CCR-03-0662"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15161709"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15161709"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "H Helmbold, N Kömm, W Deppert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rb2/p130 is the dominating pocket protein in the p53-p21 DNA damage response pathway leading to senescence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2009.222"}], "href": "https://doi.org/10.1038/onc.2009.222"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19648966"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19648966"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Zhaojian Liu, Elizabeth Gersbach, Xiyu Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-106a represses the Rb tumor suppressor p130 to regulate cellular proliferation and differentiation in high-grade serous ovarian carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-13-0131"}], "href": "https://doi.org/10.1158/1541-7786.MCR-13-0131"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24045973"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24045973"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Erica L DuPree, Suparna Mazumder, Alexandru Almasan "}, {"type": "b", "children": [{"type": "t", "text": "Genotoxic stress induces expression of E2F4, leading to its association with p130 in prostate carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-03-3695"}], "href": "https://doi.org/10.1158/0008-5472.CAN-03-3695"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15231644"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15231644"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Egle Balciunaite, Alexander Spektor, Nathan H Lents, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pocket protein complexes are recruited to distinct targets in quiescent and proliferating cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.25.18.8166-8178.2005"}], "href": "https://doi.org/10.1128/MCB.25.18.8166-8178.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16135806"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16135806"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Jihyun Chung, Vrajesh Karkhanis, Sookil Tae, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein arginine methyltransferase 5 (PRMT5) inhibition induces lymphoma cell death through reactivation of the retinoblastoma tumor suppressor pathway and polycomb repressor complex 2 (PRC2) silencing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.510669"}], "href": "https://doi.org/10.1074/jbc.M113.510669"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24189068"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24189068"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Francesca Pentimalli, Iris M Forte, Luca Esposito, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RBL2/p130 is a direct AKT target and is required to induce apoptosis upon AKT inhibition in lung cancer and mesothelioma cell lines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-018-0214-3"}], "href": "https://doi.org/10.1038/s41388-018-0214-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29606701"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29606701"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Satoko Iwahori, Angie C Umaña, Halena R VanDeusen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human cytomegalovirus-encoded viral cyclin-dependent kinase (v-CDK) UL97 phosphorylates and inactivates the retinoblastoma protein-related p107 and p130 proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M116.773150"}], "href": "https://doi.org/10.1074/jbc.M116.773150"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28289097"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28289097"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Francesco P Fiorentino, Catherine E Symonds, Marcella Macaluso, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Senescence and p130/Rbl2: a new beginning to the end."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cr.2009.96"}], "href": "https://doi.org/10.1038/cr.2009.96"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19668264"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19668264"}]}]}]}
Synonyms	P130, RB2
Proteins	RBL2_HUMAN
NCBI Gene ID	5934
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RBL2 has 8,313 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 138 datasets.

Click the + buttons to view associations for RBL2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RBL2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RBL2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of RBL2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of RBL2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of RBL2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RBL2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RBL2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving RBL2 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RBL2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RBL2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RBL2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of RBL2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RBL2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of RBL2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with RBL2 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with RBL2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with RBL2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RBL2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RBL2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RBL2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with RBL2 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing RBL2 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RBL2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RBL2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing RBL2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing RBL2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing RBL2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RBL2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RBL2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing RBL2 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RBL2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RBL2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with RBL2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with RBL2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with RBL2 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of RBL2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by RBL2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RBL2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RBL2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RBL2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RBL2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.