RBM15 Gene

HGNC Family	RNA binding motif containing (RBM)
Name	RNA binding motif protein 15
Description	Members of the SPEN (Split-end) family of proteins, including RBM15, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRBM15 is a multifunctional RNA‐binding protein that plays a key role in the epitranscriptomic regulation of gene expression. Acting as an m6A “writer,” it regulates alternative splicing by binding to pre‐mRNAs and recruiting splicing factors, thereby influencing cell‐fate decisions during hematopoiesis and megakaryocyte differentiation. For instance, in normal blood cell differentiation its modulation of pre‐mRNAs such as GATA1, RUNX1, and TAL1—as well as control over alternative splicing via SF3B1—is critical for proper lineage specification."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of hematological malignancies and viral infections, aberrant RBM15 function contributes to oncogenesis. The fusion of RBM15 with MKL1 (or MAL) via chromosomal translocations is a hallmark of acute megakaryoblastic leukemia, leading to deregulated transcriptional programs and altered epigenetic regulation via interaction with histone methyltransferases such as Setd1b. Moreover, RBM15 participates in the regulation of viral mRNA processing during Kaposi’s sarcoma-associated herpesvirus infection, and its elevated expression is associated with blast-crisis in chronic myelogenous leukemia, where its downregulation can curb proliferation, promote differentiation, and induce apoptosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn solid tumors, increased RBM15 expression and activity have been linked to enhanced malignancy through m6A-dependent stabilization and translation of oncogenic transcripts. In colorectal, renal, lung, cervical, and ovarian cancers—as well as basal-like breast cancer—RBM15-mediated m6A modification stabilizes key mRNAs (including MyD88, CXCL11, KLF1, OTUB2, EZH2, and MDR1) that drive proliferation, migration, invasion, epithelial-mesenchymal transition, metabolic reprogramming, and chemoresistance. Additionally, in severe COVID-19, RBM15 elevation in lymphocytes exacerbates programmed cell death and inflammatory responses. Collectively, these studies highlight RBM15’s broad oncogenic and regulatory roles, establishing it as an emerging therapeutic target in both hematological and solid malignancies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Li Zhang, Ngoc-Tung Tran, Hairui Su, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.07938"}], "href": "https://doi.org/10.7554/eLife.07938"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26575292"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26575292"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Arnaud Descot, Monika Rex-Haffner, Geneviève Courtois, et al. "}, {"type": "b", "children": [{"type": "t", "text": "OTT-MAL is a deregulated activator of serum response factor-dependent gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00303-08"}], "href": "https://doi.org/10.1128/MCB.00303-08"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18710951"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18710951"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jeong-Heon Lee, David G Skalnik "}, {"type": "b", "children": [{"type": "t", "text": "Rbm15-Mkl1 interacts with the Setd1b histone H3-Lys4 methyltransferase via a SPOC domain that is required for cytokine-independent proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0042965"}], "href": "https://doi.org/10.1371/journal.pone.0042965"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22927943"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22927943"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Nan Xiao, Suparna Laha, Shankar P Das, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ott1 (Rbm15) regulates thrombopoietin response in hematopoietic stem cells through alternative splicing of c-Mpl."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2014-08-593392"}], "href": "https://doi.org/10.1182/blood-2014-08-593392"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25468569"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25468569"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Vladimir Majerciak, Hiroaki Uranishi, Michael Kruhlak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Kaposi's sarcoma-associated herpesvirus ORF57 interacts with cellular RNA export cofactors RBM15 and OTT3 to promote expression of viral ORF59."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.01709-10"}], "href": "https://doi.org/10.1128/JVI.01709-10"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21106733"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21106733"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yuxia Yang, Saifeng Wang, Yanju Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Biological effects of decreasing RBM15 on chronic myelogenous leukemia cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leuk Lymphoma (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/10428194.2012.684350"}], "href": "https://doi.org/10.3109/10428194.2012.684350"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22497198"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22497198"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Taisuke Sawada, Chiharu Nishiyama, Takuma Kishi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fusion of OTT to BSAC results in aberrant up-regulation of transcriptional activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M802315200"}], "href": "https://doi.org/10.1074/jbc.M802315200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18667423"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18667423"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Lurdes Torres, Susana Lisboa, Joana Vieira, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Acute megakaryoblastic leukemia with a four-way variant translocation originating the RBM15-MKL1 fusion gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pediatr Blood Cancer (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pbc.22765"}], "href": "https://doi.org/10.1002/pbc.22765"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21370421"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21370421"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Hui-Hua Hsiao, Ming-Yu Yang, Yi-Chang Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RBM15-MKL1 (OTT-MAL) fusion transcript in an adult acute myeloid leukemia patient."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hematol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajh.20298"}], "href": "https://doi.org/10.1002/ajh.20298"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15849773"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15849773"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jing Feng, Yaling Li, Fen He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RBM15 silencing promotes ferroptosis by regulating the TGF-β/Smad2 pathway in lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Environ Toxicol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/tox.23741"}], "href": "https://doi.org/10.1002/tox.23741"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36715115"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36715115"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Zhen Zhang, Yan Mei, Mingxing Hou "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown RBM15 Inhibits Colorectal Cancer Cell Proliferation and Metastasis Via N6-Methyladenosine (m6A) Modification of MyD88 mRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biother Radiopharm (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/cbr.2021.0226"}], "href": "https://doi.org/10.1089/cbr.2021.0226"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34842457"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34842457"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Xing Zeng, Ke Chen, Le Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic activation of RBM15 promotes clear cell renal cell carcinoma growth, metastasis and macrophage infiltration by regulating the m6A modification of CXCL11."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Free Radic Biol Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.freeradbiomed.2022.03.031"}], "href": "https://doi.org/10.1016/j.freeradbiomed.2022.03.031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35381326"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35381326"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yuting Meng, Qiong Zhang, Kaihang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RBM15-mediated N6-methyladenosine modification affects COVID-19 severity by regulating the expression of multitarget genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-04012-z"}], "href": "https://doi.org/10.1038/s41419-021-04012-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34301919"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34301919"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Yan Song, Qiongwei Wu "}, {"type": "b", "children": [{"type": "t", "text": "RBM15 m"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "6"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": " A modification-mediated OTUB2 upregulation promotes cervical cancer progression via the AKT/mTOR signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Environ Toxicol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/tox.23852"}], "href": "https://doi.org/10.1002/tox.23852"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37334762"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37334762"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jia Yuan, Wencai Guan, Xin Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RBM15‑mediating MDR1 mRNA m"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "6"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": "A methylation regulated by the TGF‑β signaling pathway in paclitaxel‑resistant ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2023.5560"}], "href": "https://doi.org/10.3892/ijo.2023.5560"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37594126"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37594126"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Jiangmu Chen "}, {"type": "b", "children": [{"type": "t", "text": "Regulatory mechanism of RNA binding motif protein 15-mediated N"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "6"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": " methyladenosine modification in proliferation, invasion, and migration of colorectal cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Environ Toxicol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/tox.23883"}], "href": "https://doi.org/10.1002/tox.23883"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37471637"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37471637"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Su Hwan Park, Jin-Sung Ju, Hyunmin Woo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The m"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "6"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": "A writer RBM15 drives the growth of triple-negative breast cancer cells through the stimulation of serine and glycine metabolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Mol Med (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s12276-024-01235-w"}], "href": "https://doi.org/10.1038/s12276-024-01235-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38825643"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38825643"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Mingsheng Ma, Wei Wang, Biying Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The prognostic value of N6-methyladenosine RBM15 regulators in lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Biol (Noisy-le-grand) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14715/cmb/2022.68.1.17"}], "href": "https://doi.org/10.14715/cmb/2022.68.1.17"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35809319"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35809319"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Ruixue Wang, Wenhua Tan "}, {"type": "b", "children": [{"type": "t", "text": "RBM15-Mediated N6-Methyl Adenosine (m6A) Modification of EZH2 Drives the Epithelial-Mesenchymal Transition of Cervical Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Crit Rev Eukaryot Gene Expr (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1615/CritRevEukaryotGeneExpr.2024052205"}], "href": "https://doi.org/10.1615/CritRevEukaryotGeneExpr.2024052205"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38842201"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38842201"}]}]}]}
Synonyms	OTT, SPEN, OTT1
Proteins	RBM15_HUMAN
NCBI Gene ID	64783
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RBM15 has 10,178 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 127 datasets.

Click the + buttons to view associations for RBM15 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RBM15 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by RBM15 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RBM15 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of RBM15 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of RBM15 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of RBM15 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RBM15 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RBM15 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RBM15 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RBM15 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RBM15 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of RBM15 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RBM15 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of RBM15 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with RBM15 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with RBM15 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with RBM15 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RBM15 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RBM15 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RBM15 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with RBM15 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing RBM15 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RBM15 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RBM15 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing RBM15 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing RBM15 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing RBM15 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RBM15 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RBM15 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing RBM15 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RBM15 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RBM15 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with RBM15 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with RBM15 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of RBM15 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by RBM15 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving RBM15 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving RBM15 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RBM15 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RBM15 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RBM15 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.