RBM38 Gene

HGNC Family	RNA binding motif containing (RBM)
Name	RNA binding motif protein 38
Description	Enables mRNA 3'-UTR binding activity. Involved in DNA damage response, signal transduction by p53 class mediator; negative regulation of cell population proliferation; and regulation of gene expression. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRBM38, also known as RNPC1, is an RNA‐binding protein that exerts fundamental post‐transcriptional control over pivotal cell cycle regulators and tumor suppressor genes. In differentiating muscle cells, for instance, RBM38 binds to and stabilizes the p21 transcript—thereby promoting cell cycle arrest and proper myogenic differentiation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in differentiation, RBM38 is a critical modulator of the p53 regulatory network. It can attenuate p53 mRNA translation by impeding the interaction of translation initiation factor eIF4E with p53 messenger RNA, while under conditions that favor its phosphorylation, RBM38 interacts with eIF4G to facilitate the assembly of the translation complex and enhance p53 expression. This dual function contributes to the tight regulation of the p53–MDM2 autoregulatory loop, as RBM38 also acts to destabilize mdm2 transcripts and thereby supports p53 tumor suppressive activity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRBM38’s contribution to tumorigenesis further emerges in studies of human cancers. In hepatocellular carcinoma, the oncogenic long non‐coding RNA HOTAIR suppresses RBM38 expression—this reduction is associated with enhanced cell migration and invasion, effects that can be reversed by down‐regulating RBM38 in HOTAIR‐suppressed cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Moreover, in breast cancer, RBM38 has been implicated in regulating the expression of PTEN, a key phosphatase influencing cell survival and growth, while other investigations underscore its broader, albeit complex, roles in tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shoko Miyamoto, Kyoko Hidaka, Donghao Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNA-binding proteins Rbm38 and Rbm24 regulate myogenic differentiation via p21-dependent and -independent regulatory pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Cells (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2443.2009.01347.x"}], "href": "https://doi.org/10.1111/j.1365-2443.2009.01347.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19817877"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19817877"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jin Zhang, Seong-Jun Cho, Limin Shu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Translational repression of p53 by RNPC1, a p53 target overexpressed in lymphomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.2069311"}], "href": "https://doi.org/10.1101/gad.2069311"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21764855"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21764855"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Nicolas Léveillé, Ran Elkon, Veronica Davalos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Selective inhibition of microRNA accessibility by RBM38 is required for p53 activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms1519"}], "href": "https://doi.org/10.1038/ncomms1519"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22027593"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22027593"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "E Xu, J Zhang, X Chen "}, {"type": "b", "children": [{"type": "t", "text": "MDM2 expression is repressed by the RNA-binding protein RNPC1 via mRNA stability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2012.238"}], "href": "https://doi.org/10.1038/onc.2012.238"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22710720"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22710720"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Chaofeng Ding, Shaobing Cheng, Zhe Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA HOTAIR promotes cell migration and invasion via down-regulation of RNA binding motif protein 38 in hepatocellular carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms15034060"}], "href": "https://doi.org/10.3390/ijms15034060"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24663081"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24663081"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jin-Qiu Xue, Tian-Song Xia, Xiu-Qing Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNA-binding protein RNPC1: acting as a tumor suppressor in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-14-322"}], "href": "https://doi.org/10.1186/1471-2407-14-322"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24884756"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24884756"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Xu-Jie Zhou, Jing Wu, Liang Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PTEN expression is upregulated by a RNA-binding protein RBM38 via enhancing its mRNA stability in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-017-0620-3"}], "href": "https://doi.org/10.1186/s13046-017-0620-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29052531"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29052531"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jiazhou Ye, Rong Liang, Tao Bai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RBM38 plays a tumor-suppressor role via stabilizing the p53-mdm2 loop function in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-018-0852-x"}], "href": "https://doi.org/10.1186/s13046-018-0852-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30176896"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30176896"}]}]}]}
Synonyms	DJ800J21.2, SEB4B, SEB4D, HSRNASEB, RNPC1
Proteins	RBM38_HUMAN
NCBI Gene ID	55544
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RBM38 has 6,642 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 115 datasets.

Click the + buttons to view associations for RBM38 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RBM38 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RBM38 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of RBM38 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of RBM38 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of RBM38 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RBM38 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RBM38 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RBM38 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RBM38 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RBM38 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of RBM38 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RBM38 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of RBM38 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with RBM38 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with RBM38 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RBM38 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RBM38 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RBM38 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of RBM38 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RBM38 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RBM38 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing RBM38 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing RBM38 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing RBM38 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RBM38 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RBM38 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RBM38 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RBM38 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with RBM38 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with RBM38 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by RBM38 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with RBM38 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with RBM38 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RBM38 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RBM38 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RBM38 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RBM38 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RBM38 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RBM38 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of RBM38 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing RBM38 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.