{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough the provided texts do not mention RBMY2FP explicitly, they describe a receptor—GPR180—that functions as an important regulator of metabolic homeostasis. In the first study, GPR180 is characterized not as a classical G protein-coupled receptor but rather as an integral component of the transforming growth factor–β (TGFβ) signaling pathway. It facilitates the low‐grade activation of the pathway by modulating SMAD3 phosphorylation, thereby integrating the action of the secreted protein CTHRC1. This modulation ultimately supports the activation of thermogenic brown and beige adipocytes, contributing to improved whole‐body glucose metabolism."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}, {"type": "p", "children": [{"type": "t", "text": "\nIn the second study, the role of GPR180 is extended to hepatic lipid metabolism. Here, elevated GPR180 levels in the liver of obese, high-fat diet–induced mice are linked to increased triglyceride and cholesterol synthesis. Hepatocyte-specific knockdown or genetic deletion of Gpr180 resulted in lower lipid accumulation in both liver and plasma, reduced adiposity, and enhanced energy metabolism. These metabolic improvements are associated with the downregulation of key lipogenic transcription factors—including SREBP1 and SREBP2—and reduced PKA-mediated phosphorylation, which collectively modulate lipid synthetic pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}]}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lucia Balazova, Miroslav Balaz, Carla Horvath, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GPR180 is a component of TGFβ signalling that promotes thermogenic adipocyte function and mediates the metabolic effects of the adipocyte-secreted factor CTHRC1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-021-27442-x"}], "href": "https://doi.org/10.1038/s41467-021-27442-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34880217"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34880217"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yunhua Zhang, Ziming Zhu, Lijun Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hepatic G Protein-Coupled Receptor 180 Deficiency Ameliorates High Fat Diet-Induced Lipid Accumulation via the Gi-PKA-SREBP Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nutrients (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/nu15081838"}], "href": "https://doi.org/10.3390/nu15081838"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37111058"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37111058"}]}]}]}