RBX1 Gene

HGNC Family	Zinc fingers
Name	ring-box 1, E3 ubiquitin protein ligase
Description	This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.[provided by RefSeq, Sep 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRBX1 (also known as ROC1 or RING box protein‑1) is an essential RING‐finger subunit that assembles with cullin family members to form the core of multisubunit Cullin–RING E3 ubiquitin ligases. Structural studies have revealed that in SCF complexes, RBX1 is recruited by the globular C‐terminal domain of Cul1 to create a two‐subunit catalytic core that bridges the ubiquitin–conjugating enzyme to its substrate (1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similar principles extend to other CRLs such as the Cul2–VHL complex, where the conformation of RBX1 is critical for catalytic activation, and analyses of cullin neddylation underscore that RBX1’s interactions are modulated during complex assembly (9."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, in viral evasion strategies, HIV‑1 Vif recruits RBX1 together with Cul5 and other adaptors to induce APOBEC3G degradation, thus highlighting its versatile role in E3 ligase assembly (2."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its structural role, RBX1 is central to the substrate ubiquitination process that regulates key cellular pathways. In complexes such as the KEAP1–CUL3 ligase, RBX1 facilitates the ubiquitination and subsequent degradation of transcription factors (e.g. NRF2), while in the CUL4–DDB1 context, it promotes histone ubiquitination in response to DNA damage (3."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " RBX1‐containing CRLs also target oncogenic regulators—by promoting c‑Jun degradation via a complex assembled with DET1, DDB1, and CUL4A (5), and by controlling TSC2 stability in a FBW5–DDB1–CUL4–ROC1 complex (6)—and govern stress response pathways such as REDD1 degradation to restore mTOR signaling following hypoxic stress (7). Additional substrates include pro‑caspase‑3 and DAPK, where RBX1 activity modulates apoptotic thresholds (10, 11"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", while studies on SCF autoinhibition and pro‑caspase‑3 turnover further illustrate that fine tuning of RBX1-dependent ubiquitin ligation is vital for proper cell cycle progression and DNA replication fidelity (13, 14."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " In addition, noncoding RNA networks (e.g. the LUCAT1/miR‑514a/b‑3p axis) and other regulatory cues impact cellular RBX1 levels, indirectly affecting downstream substrates such as regulators of Cyclin D1 turnover and stress response proteins like SESN2 (24."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nClinically, aberrant RBX1 expression and activity have been linked to tumor progression, poor prognosis, and resistance to therapy in a number of human cancers. Silencing studies in various cancer cell lines demonstrate that loss of RBX1 activity can induce cell cycle arrest, senescence, and apoptosis, underscoring its potential as an anticancer target (8). Elevated RBX1 levels correlate with adverse outcomes in liver, ovarian, esophageal, and non‑small cell lung cancers, while in bladder cancer, dysregulated RBX1 contributes to oncogenic NF‑κB signaling and malignant progression (15."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "15"}]}, {"type": "t", "text": " Innovative therapeutic approaches—including siRNA‐mediated silencing delivered by nanomedicines and strategies targeting its engagement in CRL complexes—have shown promise in preclinical models, and defects in RBX1 function are also implicated in rare inherited disorders via quality‑control mechanisms (31, 32."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xianghui Yu, Yunkai Yu, Bindong Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1089591"}], "href": "https://doi.org/10.1126/science.1089591"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14564014"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14564014"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Alexander Y Kim, Claire C Bommeljé, Benjamin E Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M804440200"}], "href": "https://doi.org/10.1074/jbc.M804440200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18826954"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18826954"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "David M Duda, Jennifer L Olszewski, Adriana E Tron, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure of a glomulin-RBX1-CUL1 complex: inhibition of a RING E3 ligase through masking of its E2-binding surface."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2012.05.044"}], "href": "https://doi.org/10.1016/j.molcel.2012.05.044"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22748924"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22748924"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiaodan Wang, Xiaoying Wang, Weiran Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Both Rbx1 and Rbx2 exhibit a functional role in the HIV-1 Vif-Cullin5 E3 ligase complex in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2015.04.077"}], "href": "https://doi.org/10.1016/j.bbrc.2015.04.077"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25912140"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25912140"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hengbin Wang, Ling Zhai, Jun Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2006.03.035"}], "href": "https://doi.org/10.1016/j.molcel.2006.03.035"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16678110"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16678110"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Shasha Tao, Pengfei Liu, Gang Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p97 Negatively Regulates NRF2 by Extracting Ubiquitylated NRF2 from the KEAP1-CUL3 E3 Complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00660-16"}], "href": "https://doi.org/10.1128/MCB.00660-16"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28115426"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28115426"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jiaqing Hao, Xiao Song, Jingjing Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cancer-testis antigen MAGE-C2 binds Rbx1 and inhibits ubiquitin ligase-mediated turnover of cyclin E."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.5973"}], "href": "https://doi.org/10.18632/oncotarget.5973"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26540345"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26540345"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Ying Xie, Yi-Ke Liu, Zong-Pei Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RBX1 prompts degradation of EXO1 to limit the homologous recombination pathway of DNA double-strand break repair in G1 phase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41418-019-0424-4"}], "href": "https://doi.org/10.1038/s41418-019-0424-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31562368"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31562368"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Ashish Kumar, Chandrima Shaha "}, {"type": "b", "children": [{"type": "t", "text": "RBX1-mediated ubiquitination of SESN2 promotes cell death upon prolonged mitochondrial damage in SH-SY5Y neuroblastoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-017-3267-7"}], "href": "https://doi.org/10.1007/s11010-017-3267-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29294217"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29294217"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Gisele Nai, Mariângela Marques "}, {"type": "b", "children": [{"type": "t", "text": "Role of ROC1 protein in the control of cyclin D1 protein expression in skin melanomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2011.01.001"}], "href": "https://doi.org/10.1016/j.prp.2011.01.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21300445"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21300445"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Victor D Martinez, Emily A Vucic, Kelsie L Thu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Unique pattern of component gene disruption in the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in serous ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2014/159459"}], "href": "https://doi.org/10.1155/2014/159459"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25114896"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25114896"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Manisha Bungsy, Michaela C L Palmer, Lucile M Jeusset, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reduced RBX1 expression induces chromosome instability and promotes cellular transformation in high-grade serous ovarian cancer precursor cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2020.11.051"}], "href": "https://doi.org/10.1016/j.canlet.2020.11.051"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33290867"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33290867"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Jingyang Zhang, Shuo Li, Zhaoyang Shang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeting the overexpressed ROC1 induces G2 cell cycle arrest and apoptosis in esophageal cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.16250"}], "href": "https://doi.org/10.18632/oncotarget.16250"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28418860"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28418860"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Rui Xing, Kuan-Bing Chen, Ying Xuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RBX1 expression is an unfavorable prognostic factor in patients with non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Surg Oncol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.suronc.2016.05.006"}], "href": "https://doi.org/10.1016/j.suronc.2016.05.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27566015"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27566015"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "W Wang, H Chen, Z Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulator of cullins-1 expression knockdown suppresses the malignant progression of muscle-invasive transitional cell carcinoma by regulating mTOR/DEPTOR pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Cancer (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/bjc.2015.444"}], "href": "https://doi.org/10.1038/bjc.2015.444"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26742010"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26742010"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Yasuhiro Miyauchi-Nanri, Satoru Mukai, Kosuke Kuroda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CUL4A-DDB1-Rbx1 E3 ligase controls the quality of the PTS2 receptor Pex7p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20130861"}], "href": "https://doi.org/10.1042/BJ20130861"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24989250"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24989250"}]}]}]}
Synonyms	RNF75, BA554C12.1
Proteins	RBX1_HUMAN
NCBI Gene ID	9978
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RBX1 has 9,035 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 118 datasets.

Click the + buttons to view associations for RBX1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RBX1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by RBX1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RBX1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of RBX1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of RBX1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RBX1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RBX1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving RBX1 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RBX1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RBX1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RBX1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of RBX1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RBX1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of RBX1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with RBX1 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RBX1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RBX1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RBX1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RBX1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RBX1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing RBX1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RBX1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RBX1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing RBX1 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RBX1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RBX1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with RBX1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of RBX1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with RBX1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RBX1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RBX1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RBX1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RBX1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RBX1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RBX1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of RBX1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing RBX1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of RBX1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with RBX1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing RBX1 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of RBX1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.