RCE1 Gene

Name	Ras converting CAAX endopeptidase 1
Description	This gene encodes an integral membrane protein which is classified as a member of the metalloproteinase family. This enzyme is thought to function in the maintenance and processing of CAAX-type prenylated proteins. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRCE1 is an integral membrane protease that catalyzes a crucial posttranslational step for proteins harboring a C-terminal CAAX motif. By cleaving the terminal AAX tripeptide from substrates such as farnesylated lamin B1 and Ras isoforms, RCE1 facilitates subsequent modifications—like carboxymethylation—that are essential for proper protein membrane targeting and nuclear lamina organization. This precise processing governs both the structural integrity of the nuclear envelope and the spatial regulation of key signaling molecules."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAlterations in RCE1 expression and activity have been linked to the progression of several cancers. Aberrant RCE1 levels correlate with aggressive clinicopathologic features in prostate and renal cell carcinomas, where overexpression is associated with decreased apoptosis and poorer patient outcomes. Conversely, in hepatocellular carcinoma, reduced RCE1 expression disrupts proper H‐Ras processing, thereby enhancing epithelial–mesenchymal transition and promoting invasion and metastasis. Similar observations in colorectal carcinoma underscore its potential utility as an independent prognostic marker and a therapeutic target in malignancy."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistic studies have revealed that RCE1’s enzymatic activity relies on conserved catalytic residues positioned within or near its transmembrane segments, which determine its substrate specificity and overall function. In addition, regulatory mechanisms—including alternative splicing that gives rise to distinct isoforms and modulation by deubiquitinating enzymes such as USP17—further influence RCE1 stability and localization. These insights not only clarify how RCE1 directs critical processing events in diverse cellular contexts but also open avenues for the development of peptidomimetic inhibitors aimed at treating cancer and inflammatory diseases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Irwin J Hollander, Eileen Frommer, Ann Aulabaugh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human Ras converting enzyme endoproteolytic specificity at the P2' and P3' positions of K-Ras-derived peptides."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1570-9639(03)00150-x"}], "href": "https://doi.org/10.1016/s1570-9639(03"}, {"type": "t", "text": "00150-x) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12818187"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12818187"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Christopher P Maske, Michael S Hollinshead, Niall C Higbee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A carboxyl-terminal interaction of lamin B1 is dependent on the CAAX endoprotease Rce1 and carboxymethylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200303113"}], "href": "https://doi.org/10.1083/jcb.200303113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14504265"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14504265"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lisa J Plummer, Emily R Hildebrandt, Stephen B Porter, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutational analysis of the ras converting enzyme reveals a requirement for glutamate and histidine residues."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M506284200"}], "href": "https://doi.org/10.1074/jbc.M506284200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16361710"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16361710"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jakub Jaworski, Ureshnie Govender, Cheryl McFarlane, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel RCE1 isoform is required for H-Ras plasma membrane localization and is regulated by USP17."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20131213"}], "href": "https://doi.org/10.1042/BJ20131213"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24134311"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24134311"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Liangliang Huang, Meicai Li, Delin Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpressed Rce1 is positively correlated with tumor progression and predicts poor prognosis in prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Pathol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.humpath.2015.08.021"}], "href": "https://doi.org/10.1016/j.humpath.2015.08.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26546252"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26546252"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jianjun Li, Delin Wang, Junnan Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rce1 expression in renal cell carcinoma and its regulatory effect on 786-O cell apoptosis through endoplasmic reticulum stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Biochim Biophys Sin (Shanghai) (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/abbs/gmx002"}], "href": "https://doi.org/10.1093/abbs/gmx002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28159979"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28159979"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Boyun Shi, Xinke Zhou, Lu He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reduced RCE1 expression predicts poor prognosis of colorectal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-017-3393-3"}], "href": "https://doi.org/10.1186/s12885-017-3393-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28615075"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28615075"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Chaoqun Ma, Yan Yang, Lei Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rce1 suppresses invasion and metastasis of hepatocellular carcinoma via epithelial-mesenchymal transition induced by the TGF-β1/H-Ras signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.29155"}], "href": "https://doi.org/10.1002/jcp.29155"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31506952"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31506952"}]}]}]}
Synonyms	RCE1B, RCE1A, FACE2
Proteins	FACE2_HUMAN
NCBI Gene ID	9986
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RCE1 has 5,103 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 109 datasets.

Click the + buttons to view associations for RCE1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RCE1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RCE1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of RCE1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of RCE1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of RCE1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RCE1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RCE1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RCE1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RCE1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RCE1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of RCE1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RCE1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of RCE1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with RCE1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with RCE1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RCE1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RCE1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RCE1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of RCE1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RCE1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RCE1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing RCE1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RCE1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RCE1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RCE1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RCE1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with RCE1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of RCE1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by RCE1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for RCE1 protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with RCE1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RCE1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RCE1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RCE1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RCE1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RCE1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RCE1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of RCE1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing RCE1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of RCE1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with RCE1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.