RDH5 Gene

HGNC Family	Short chain dehydrogenase/reductase superfamily (SDR)
Name	retinol dehydrogenase 5 (11-cis/9-cis)
Description	This gene encodes an enzyme belonging to the short-chain dehydrogenases/reductases (SDR) family. This retinol dehydrogenase functions to catalyze the final step in the biosynthesis of 11-cis retinaldehyde, which is the universal chromophore of visual pigments. Mutations in this gene cause autosomal recessive fundus albipunctatus, a rare form of night blindness that is characterized by a delay in the regeneration of cone and rod photopigments. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S1 (biogenesis of lysosomal organelles complex-1, subunit 1) gene. [provided by RefSeq, Dec 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRetinol dehydrogenase‐5 (RDH5) is a key enzyme of the visual cycle, catalyzing the oxidation of retinol derivatives in the retinal pigment epithelium to regenerate the visual chromophore essential for phototransduction. Multiple studies have shown that mutations in the RDH5 gene cause fundus albipunctatus, a congenital, stationary form of night blindness characterized by delayed dark adaptation and distinctive white or flecked fundus patterns. In addition, RDH5 expression is tightly regulated by key transcription factors such as MITF, highlighting its central role in RPE development and retinoid processing. These findings, derived from detailed mutational analyses and clinical phenotyping in diverse patient cohorts, have provided insight into the variable expressivity of the disease, including cases with macular or cone dystrophy."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurther investigations employing electrophysiological studies and high‐resolution retinal imaging (including adaptive optics and spectral-domain optical coherence tomography) have revealed that RDH5 mutations are associated with a spectrum of retinal phenotypes. In some patients, despite delayed rod recovery under short dark-adaptation, prolonged dark conditions lead to normalization of responses—whereas in others, electrophysiological anomalies correlate with progressive cone dysfunction or macular atrophy. Such phenotypic variability is also observed in cases overlapping with retinitis pigmentosa, underscoring the complex clinical manifestation emerging from distinct RDH5 alleles."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its established role in the visual cycle, recent studies have begun to uncover additional functions of RDH5 and its related enzyme family. Experimental evidence suggests that evolutionary alterations in the substrate-binding residues of retinol dehydrogenases not only tailor visual pigment regeneration but may also confer roles in broader retinoid metabolism. Intriguingly, downregulation of RDH5 in hepatocellular carcinoma has been linked to enhanced cell proliferation and metastasis via activation of the Hippo/YAP pathway, revealing a potential tumor-suppressive function for this enzyme."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "22"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Makoto Nakamura, Yozo Miyake "}, {"type": "b", "children": [{"type": "t", "text": "Macular dystrophy in a 9-year-old boy with fundus albipunctatus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Ophthalmol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0002-9394(01)01304-6"}], "href": "https://doi.org/10.1016/s0002-9394(01"}, {"type": "t", "text": "01304-6) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11812441"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11812441"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kazuki Hotta, Makoto Nakamura, Mineo Kondo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Macular dystrophy in a Japanese family with fundus albipunctatus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Ophthalmol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0002-9394(02)02290-0"}], "href": "https://doi.org/10.1016/s0002-9394(02"}, {"type": "t", "text": "02290-0) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12788147"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12788147"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Makoto Nakamura, Jason Skalet, Yozo Miyake "}, {"type": "b", "children": [{"type": "t", "text": "RDH5 gene mutations and electroretinogram in fundus albipunctatus with or without macular dystrophy: RDH5 mutations and ERG in fundus albipunctatus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Doc Ophthalmol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1023/a:1024498826904"}], "href": "https://doi.org/10.1023/a:1024498826904"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12906118"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12906118"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hiroyuki Yamamoto, Kimikazu Yakushijin, Sentaro Kusuhara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel RDH5 gene mutation in a patient with fundus albipunctatus presenting with macular atrophy and fading white dots."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Ophthalmol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0002-9394(03)00332-5"}], "href": "https://doi.org/10.1016/s0002-9394(03"}, {"type": "t", "text": "00332-5) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12967826"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12967826"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Masaki Sato, Tetsuro Oshika, Yuuichi Kaji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel homozygous Gly107Arg mutation in the RDH5 gene in a Japanese patient with fundus albipunctatus with sectorial retinitis pigmentosa."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ophthalmic Res (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000076109"}], "href": "https://doi.org/10.1159/000076109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15007239"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15007239"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Makoto Nakamura, Jian Lin, Yozo Miyake "}, {"type": "b", "children": [{"type": "t", "text": "Young monozygotic twin sisters with fundus albipunctatus and cone dystrophy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Ophthalmol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1001/archopht.122.8.1203"}], "href": "https://doi.org/10.1001/archopht.122.8.1203"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15302662"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15302662"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Takaaki Hayashi, Satoshi Goto-Omoto, Tomokazu Takeuchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Compound heterozygous RDH5 mutations in familial fleck retina with night blindness."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Ophthalmol Scand (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1600-0420.2005.00575.x"}], "href": "https://doi.org/10.1111/j.1600-0420.2005.00575.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16637847"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16637847"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Chunxia Wang, Nobuo Nakanishi, Kentaro Ohishi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel RDH5 mutation in family with mother having fundus albipunctatus and three children with retinitis pigmentosa."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ophthalmic Genet (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/13816810701663535"}], "href": "https://doi.org/10.1080/13816810701663535"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18363170"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18363170"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Patrik Schatz, Markus Preising, Birgit Lorenz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lack of autofluorescence in fundus albipunctatus associated with mutations in RDH5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Retina (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/IAE.0b013e3181dc050a"}], "href": "https://doi.org/10.1097/IAE.0b013e3181dc050a"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20829743"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20829743"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Panagiotis I Sergouniotis, Elliott H Sohn, Zheng Li, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Multimodal fundus imaging in fundus albipunctatus with RDH5 mutation: a newly identified compound heterozygous mutation and review of the literature."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Doc Ophthalmol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10633-012-9336-z"}], "href": "https://doi.org/10.1007/s10633-012-9336-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22669287"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22669287"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Muhammad Ajmal, Muhammad Imran Khan, Kornelia Neveling, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "RDH5 retinopathy (fundus albipunctatus) with preserved rod function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Retina (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/IAE.0000000000000319"}], "href": "https://doi.org/10.1097/IAE.0000000000000319"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25170858"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25170858"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Bin Wen, Shuang Li, Huirong Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Microphthalmia-associated transcription factor regulates the visual cycle genes Rlbp1 and Rdh5 in the retinal pigment epithelium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep21208"}], "href": "https://doi.org/10.1038/srep21208"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26876013"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26876013"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Rizwan Khan, Rana Muhammad Kamran Shabbir, Irum Raza, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A founder "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "RDH5"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " splice site mutation leads to retinitis punctata albescens in two inbred Pakistani kindreds."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ophthalmic Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/13816810.2019.1709124"}], "href": "https://doi.org/10.1080/13816810.2019.1709124"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31933420"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31933420"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Satoshi Katagiri, Takaaki Hayashi, Masaki Nakamura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RDH5-Related Fundus Albipunctatus in a Large Japanese Cohort."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Invest Ophthalmol Vis Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1167/iovs.61.3.53"}], "href": "https://doi.org/10.1167/iovs.61.3.53"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32232344"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32232344"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Tianwei Qian, Qiaoyun Gong, Hangqi Shen, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Molecular framework of steroid/retinoid discrimination in 17beta-hydroxysteroid dehydrogenase type 1 and photoreceptor-associated retinol dehydrogenase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2010.04.002"}], "href": "https://doi.org/10.1016/j.jmb.2010.04.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20382160"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20382160"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Hao Hu, Liang Xu, Shao-Ju Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Retinal dehydrogenase 5 (RHD5) attenuates metastasis via regulating HIPPO/YAP signaling pathway in Hepatocellular Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Med Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/ijms.46091"}], "href": "https://doi.org/10.7150/ijms.46091"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32788868"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32788868"}]}]}]}
Synonyms	HSD17B9, 9CRDH, RDH1, SDR9C5
Proteins	RDH1_HUMAN
NCBI Gene ID	5959
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RDH5 has 4,359 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 115 datasets.

Click the + buttons to view associations for RDH5 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RDH5 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by RDH5 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RDH5 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of RDH5 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of RDH5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RDH5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RDH5 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RDH5 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RDH5 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RDH5 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RDH5 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RDH5 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RDH5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RDH5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RDH5 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RDH5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing RDH5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RDH5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RDH5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RDH5 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RDH5 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with RDH5 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with RDH5 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by RDH5 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving RDH5 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with RDH5 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with RDH5 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RDH5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RDH5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RDH5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RDH5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for RDH5 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RDH5 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RDH5 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of RDH5 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing RDH5 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with RDH5 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with RDH5 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of RDH5 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with RDH5 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing RDH5 from the GeneSigDB Published Gene Signatures dataset.