REEP1 Gene

HGNC Family	Receptor accessory proteins (REEP)
Name	receptor accessory protein 1
Description	This gene encodes a mitochondrial protein that functions to enhance the cell surface expression of odorant receptors. Mutations in this gene cause spastic paraplegia autosomal dominant type 31, a neurodegenerative disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nREEP1 is a neuronally restricted membrane protein that plays a pivotal role in determining the structure and function of the endoplasmic reticulum (ER) in nerve cells. It belongs to the DP1/Yop1p family and is critical for inducing membrane curvature, thereby promoting the formation and maintenance of the tubular ER network. In neuronal cells—particularly corticospinal and motor neurons—REEP1 interacts with atlastin‐1 and spastin to coordinate ER shaping and its alignment with the microtubule cytoskeleton, which is essential for long‐term axonal integrity. Disruption of these interactions through loss‐of‐function mutations impairs ER morphology and contributes to neurodegenerative processes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in delineating ER architecture, REEP1 contributes to the efficient trafficking and cell surface expression of difficult‐to‐express G protein–coupled receptors. Studies using heterologous expression systems have demonstrated that coexpression of REEP proteins enhances receptor delivery, as seen with bitter taste receptors. Furthermore, in certain contexts REEP1 has been reported to localize to mitochondria, where mutations can lead to aberrant mitochondrial network organization and deficits in energy production—suggesting that REEP1 might integrate ER dynamics with aspects of mitochondrial homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGenetic studies have revealed a broad spectrum of REEP1 mutations underlying various neurodegenerative conditions—including autosomal dominant hereditary spastic paraplegia (SPG31), distal hereditary motor neuropathy, and even variants associated with primary progressive multiple sclerosis. Mutations ranging from splice‐site alterations and exon deletions to nonstop variants have been shown to cause either haploinsufficiency or toxic gain‐of‐function via mislocalization and protein aggregation. Clinically, these diverse genetic lesions manifest in phenotypes that range from pure spastic paraplegia to more complex presentations with peripheral nerve involvement, emphasizing the central role of REEP1 in both upper and lower motor neuron maintenance."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Seong H Park, Peng-Peng Zhu, Rell L Parker, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER network."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI40979"}], "href": "https://doi.org/10.1172/JCI40979"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20200447"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20200447"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "S T de Bot, J H Veldink, S Vermeer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ATL1 and REEP1 mutations in hereditary and sporadic upper motor neuron syndromes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00415-012-6723-z"}], "href": "https://doi.org/10.1007/s00415-012-6723-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23108492"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23108492"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Christian Beetz, Nicole Koch, Mukhran Khundadze, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A spastic paraplegia mouse model reveals REEP1-dependent ER shaping."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI65665"}], "href": "https://doi.org/10.1172/JCI65665"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24051375"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24051375"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Julia Falk, Magdalena Rohde, Mohamed M Bekhite, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional mutation analysis provides evidence for a role of REEP1 in lipid droplet biology."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.22521"}], "href": "https://doi.org/10.1002/humu.22521"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24478229"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24478229"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Youngshin Lim, Il-Taeg Cho, Leah J Schoel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hereditary spastic paraplegia-linked REEP1 modulates endoplasmic reticulum/mitochondria contacts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Neurol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ana.24488"}], "href": "https://doi.org/10.1002/ana.24488"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26201691"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26201691"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ewelina Elert-Dobkowska, Iwona Stepniak, Wioletta Krysa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular spectrum of the SPAST, ATL1 and REEP1 gene mutations associated with the most common hereditary spastic paraplegias in a group of Polish patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurol Sci (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jns.2015.10.030"}], "href": "https://doi.org/10.1016/j.jns.2015.10.030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26671083"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26671083"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Masaki Kamada, Toshitaka Kawarai, Ryosuke Miyamoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Spastic paraplegia type 31: A novel REEP1 splice site donor variant and expansion of the phenotype variability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Parkinsonism Relat Disord (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.parkreldis.2017.10.012"}], "href": "https://doi.org/10.1016/j.parkreldis.2017.10.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29107646"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29107646"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Gang Xu, Yan Niu, Shujuan Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Deletional variant of REEP1 gene in a pedigree affected with spastic paraplegia type 31]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Yi Xue Yi Chuan Xue Za Zhi (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3760/cma.j.issn.1003-9406.2019.06.012"}], "href": "https://doi.org/10.3760/cma.j.issn.1003-9406.2019.06.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31055810"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31055810"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Maik Behrens, Juliane Bartelt, Claudia Reichling, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Members of RTP and REEP gene families influence functional bitter taste receptor expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M513637200"}], "href": "https://doi.org/10.1074/jbc.M513637200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16720576"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16720576"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Stephan Züchner, Gaofeng Wang, Khanh-Nhat Tran-Viet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in the novel mitochondrial protein REEP1 cause hereditary spastic paraplegia type 31."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1086/505361"}], "href": "https://doi.org/10.1086/505361"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16826527"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16826527"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Cyril Goizet, Christel Depienne, Giovanni Benard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "REEP1 mutations in SPG31: frequency, mutational spectrum, and potential association with mitochondrial morpho-functional dysfunction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.21542"}], "href": "https://doi.org/10.1002/humu.21542"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21618648"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21618648"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Carl M Hurt, Susann Björk, Vincent K Ho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "REEP1 and REEP2 proteins are preferentially expressed in neuronal and neuronal-like exocytotic tissues."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.brainres.2013.12.008"}], "href": "https://doi.org/10.1016/j.brainres.2013.12.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24355597"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24355597"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Christian Beetz, Rebecca Schüle, Tine Deconinck, et al. "}, {"type": "b", "children": [{"type": "t", "text": "REEP1 mutation spectrum and genotype/phenotype correlation in hereditary spastic paraplegia type 31."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/brain/awn026"}], "href": "https://doi.org/10.1093/brain/awn026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18321925"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18321925"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Shi Guo Liu, Feng Yuan Che, Xue Yuan Heng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical and genetic study of a novel mutation in the REEP1 gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Synapse (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/syn.20602"}], "href": "https://doi.org/10.1002/syn.20602"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19072839"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19072839"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Christian Beetz, Thomas R Pieber, Nicole Hertel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exome sequencing identifies a REEP1 mutation involved in distal hereditary motor neuropathy type V."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2012.05.007"}], "href": "https://doi.org/10.1016/j.ajhg.2012.05.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22703882"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22703882"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Servi J C Stevens, Eveline W Blom, Ingrid T J Siegelaer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A recurrent deletion syndrome at chromosome bands 2p11.2-2p12 flanked by segmental duplications at the breakpoints and including REEP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ejhg.2014.124"}], "href": "https://doi.org/10.1038/ejhg.2014.124"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24986827"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24986827"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Andrea S Bock, Sven Günther, Julia Mohr, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A nonstop variant in REEP1 causes peripheral neuropathy by unmasking a 3'UTR-encoded, aggregation-inducing motif."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.23369"}], "href": "https://doi.org/10.1002/humu.23369"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29124833"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29124833"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Xiaoming Jia, Lohith Madireddy, Stacy Caillier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome sequencing uncovers phenocopies in primary progressive multiple sclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Neurol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ana.25263"}], "href": "https://doi.org/10.1002/ana.25263"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29908077"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29908077"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Anders Toft, Steffen Birk, Martin Ballegaard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Peripheral neuropathy in hereditary spastic paraplegia caused by REEP1 variants."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00415-019-09196-1"}], "href": "https://doi.org/10.1007/s00415-019-09196-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30637453"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30637453"}]}]}]}
Synonyms	HMN5B, SPG31, Yip2a, C2ORF23
Proteins	REEP1_HUMAN
NCBI Gene ID	65055
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

REEP1 has 7,364 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 122 datasets.

Click the + buttons to view associations for REEP1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

REEP1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of REEP1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of REEP1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of REEP1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of REEP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of REEP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of REEP1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of REEP1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of REEP1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of REEP1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of REEP1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of REEP1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of REEP1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with REEP1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of REEP1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of REEP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of REEP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with REEP1 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with REEP1 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of REEP1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing REEP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing REEP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with REEP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with REEP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing REEP1 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of REEP1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with REEP1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with REEP1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with REEP1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of REEP1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by REEP1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving REEP1 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving REEP1 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with REEP1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with REEP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with REEP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with REEP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with REEP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at REEP1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of REEP1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of REEP1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.