RELB Gene

Name v-rel avian reticuloendotheliosis viral oncogene homolog B
Description Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and protein kinase binding activity. Involved in lymphocyte differentiation and negative regulation of interferon-beta production. Located in several cellular components, including centrosome; chromatin; and nucleoplasm. Part of nucleus and transcription repressor complex. Implicated in breast cancer and immunodeficiency 53. Biomarker of breast cancer and transitional cell carcinoma. [provided by Alliance of Genome Resources, Mar 2025]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRELB, a member of the noncanonical NF‑κB pathway, plays a pivotal role in immune cell differentiation and the establishment of endotoxin tolerance. In dendritic cells, for example, a slowly activating p52/RelB dimer gradually displaces the rapidly induced p50/RelA complex during maturation, thereby fine‐tuning the temporal profile of target gene activation despite the resynthesis of inhibitory IκB proteins. In models of endotoxin tolerance, RELB upregulation correlates with the repression of acute proinflammatory cytokine genes through direct interactions with chromatin modifiers such as the histone H3K9 methyltransferase G9a and heterochromatin protein 1, while concurrently supporting the sustained expression of anti‑inflammatory proteins such as IκBα."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn cancer, aberrant RELB activity contributes to tumorigenesis and therapy resistance by promoting survival and aggressive phenotypes. In prostate and breast cancer cells, elevated RELB supports resistance to radiation and chemotherapeutic stress by inducing the antioxidant enzyme manganese superoxide dismutase and upregulating pro‑survival cytokines such as interleukin‑8. In the tumor microenvironment, RELB participates in immunosuppressive circuits—such as driving indoleamine 2,3-dioxygenase (IDO) expression in myeloid-derived suppressor cells—and it is upregulated via CD40 signaling and adhesion receptor pathways to enhance lymphoma cell survival. In diffuse large B-cell lymphoma, for instance, constitutive RELB activation is linked to poor clinical outcomes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThe regulation of RELB involves diverse upstream signals and cross‑talk with other transcriptional regulators. Activation of the aryl hydrocarbon receptor (AhR) can lead to the formation of AhR/RELB complexes that drive chemokine transcription, whereas proteolytic processing by MALT1 controls RELB stability and thus modulates canonical NF‑κB activation. Additionally, IKKα‑dependent signaling and CD40 stimulation promote RELB-dependent transcription—such as the induction of cell cycle regulators like skp2—while Rac1 GTPase activity facilitates the nuclear translocation of RELB. Moreover, interactions with co‑regulatory factors such as the REQ adaptor link RELB/p52 dimers with chromatin remodeling complexes to induce downstream gene expression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "22"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its central roles in immunity and oncogenesis, RELB participates in additional physiological processes and is subject to further layers of regulation. In fibroblasts, RELB acts as a repressor of circadian transcription by interacting with clock activators such as BMAL1, and specific phosphorylation events (for example, at conserved serine residues) are critical for its dimerization and for regulating the processing of its NF‑κB precursors. In esophageal squamous cell carcinoma, NF‑κB p65/RELB binding sites in the promoter of the riboflavin transporter gene SLC52A3 mediate aberrant gene transcription linked to tumor progression, while in pulmonary epithelial cells, hypercapnic exposure leads to the proteasome-dependent cleavage and nuclear translocation of RELB that contributes to protection against lung injury. In the placenta, RELB cooperates with NF‑κB2 to regulate corticotropin-releasing hormone expression, and in antigen-presenting cells, RELB-containing dimers modulate cytokine production and can attenuate interferon‑β expression during viral sensing. Finally, autophagy‐dependent degradation of signaling scaffolds in RAS mutant cancers results in selective RELB activation, which in turn represses certain TGF‑β target genes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "23", "end_ref": "31"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Simona Saccani, Serafino Pantano, Gioacchino Natoli "}, {"type": "b", "children": [{"type": "t", "text": "Modulation of NF-kappaB activity by exchange of dimers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1097-2765(03)00227-2"}], "href": "https://doi.org/10.1016/s1097-2765(03"}, {"type": "t", "text": "00227-2) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12820969"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12820969"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Pedro J Cejas, Louise M Carlson, Despina Kolonias, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of RelB expression during the initiation of dendritic cell differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.25.17.7900-7916.2005"}], "href": "https://doi.org/10.1128/MCB.25.17.7900-7916.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16107733"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16107733"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Barbara K Yoza, Jean Y-Q Hu, Sue L Cousart, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Induction of RelB participates in endotoxin tolerance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.177.6.4080"}], "href": "https://doi.org/10.4049/jimmunol.177.6.4080"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16951372"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16951372"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiaoping Chen, Mohamed El Gazzar, Barbara K Yoza, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The NF-kappaB factor RelB and histone H3 lysine methyltransferase G9a directly interact to generate epigenetic silencing in endotoxin tolerance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.000950"}], "href": "https://doi.org/10.1074/jbc.M109.000950"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19690169"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19690169"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xiaoping Chen, Barbara K Yoza, Mohamed El Gazzar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RelB sustains IkappaBalpha expression during endotoxin tolerance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Vaccine Immunol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/CVI.00320-08"}], "href": "https://doi.org/10.1128/CVI.00320-08"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19020113"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19020113"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "S Josson, Y Xu, F Fang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RelB regulates manganese superoxide dismutase gene and resistance to ionizing radiation of prostate cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1209186"}], "href": "https://doi.org/10.1038/sj.onc.1209186"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16261162"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16261162"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yong Xu, Sajni Josson, Fang Fang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RelB enhances prostate cancer growth: implications for the role of the nuclear factor-kappaB alternative pathway in tumorigenicity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-08-4635"}], "href": "https://doi.org/10.1158/0008-5472.CAN-08-4635"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19351823"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19351823"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xiaobo Wang, Karine Belguise, Christine F O'Neill, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RelB NF-kappaB represses estrogen receptor alpha expression via induction of the zinc finger protein Blimp1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00032-09"}], "href": "https://doi.org/10.1128/MCB.00032-09"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19433448"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19433448"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Stella M Ranuncolo, Stefania Pittaluga, Moses O Evbuomwan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hodgkin lymphoma requires stabilized NIK and constitutive RelB expression for survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2012-01-405951"}], "href": "https://doi.org/10.1182/blood-2012-01-405951"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22968463"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22968463"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jinpu Yu, Yue Wang, Fang Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Noncanonical NF-κB activation mediates STAT3-stimulated IDO upregulation in myeloid-derived suppressor cells in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1400833"}], "href": "https://doi.org/10.4049/jimmunol.1400833"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25063873"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25063873"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Miriam C Peeters, Michiel Fokkelman, Bob Boogaard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The adhesion G protein-coupled receptor G2 (ADGRG2/GPR64) constitutively activates SRE and NFκB and is involved in cell adhesion and migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2015.08.015"}], "href": "https://doi.org/10.1016/j.cellsig.2015.08.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26321231"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26321231"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Subrahmanya D Vallabhapurapu, Sunil K Noothi, Derek A Pullum, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional repression by the HDAC4-RelB-p52 complex regulates multiple myeloma survival and growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms9428"}], "href": "https://doi.org/10.1038/ncomms9428"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26455434"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26455434"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Nora D Mineva, Thomas L Rothstein, John A Meyers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CD40 ligand-mediated activation of the de novo RelB NF-kappaB synthesis pathway in transformed B cells promotes rescue from apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M607313200"}], "href": "https://doi.org/10.1074/jbc.M607313200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17446175"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17446175"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Nora D Mineva, Xiaobo Wang, Sanghwa Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of RelB by 1,25-dihydroxyvitamin D3 promotes sensitivity of breast cancer cells to radiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.21765"}], "href": "https://doi.org/10.1002/jcp.21765"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19373868"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19373868"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Baptiste Eluard, Stéphanie Nuan-Aliman, Nathalie Faumont, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The alternative RelB NF-κB subunit is a novel critical player in diffuse large B-cell lymphoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood.2020010039"}], "href": "https://doi.org/10.1182/blood.2020010039"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34232979"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34232979"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Christoph F A Vogel, Eric Sciullo, Wen Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RelB, a new partner of aryl hydrocarbon receptor-mediated transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2007-0211"}], "href": "https://doi.org/10.1210/me.2007-0211"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17823304"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17823304"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Stephan Hailfinger, Hendrik Nogai, Christiane Pelzer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1105020108"}], "href": "https://doi.org/10.1073/pnas.1105020108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21873235"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21873235"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Günter Schneider, Dieter Saur, Jens T Siveke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IKKalpha controls p52/RelB at the skp2 gene promoter to regulate G1- to S-phase progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.emboj.7601259"}], "href": "https://doi.org/10.1038/sj.emboj.7601259"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16902410"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16902410"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Christoph F A Vogel, Eric Sciullo, Fumio Matsumura "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of RelB in aryl hydrocarbon receptor-mediated induction of chemokines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2007.09.032"}], "href": "https://doi.org/10.1016/j.bbrc.2007.09.032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17900530"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17900530"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Paulo Matos, Peter Jordan "}, {"type": "b", "children": [{"type": "t", "text": "Rac1, but not Rac1B, stimulates RelB-mediated gene transcription in colorectal cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M513243200"}], "href": "https://doi.org/10.1074/jbc.M513243200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16551621"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16551621"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Toshio Tando, Aya Ishizaka, Hirotaka Watanabe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a noncanonical NF-kappaB pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.087783"}], "href": "https://doi.org/10.1074/jbc.M109.087783"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20460684"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20460684"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Casey W Wright, Colin S Duckett "}, {"type": "b", "children": [{"type": "t", "text": "The aryl hydrocarbon nuclear translocator alters CD30-mediated NF-kappaB-dependent transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1162818"}], "href": "https://doi.org/10.1126/science.1162818"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19131627"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19131627"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Marina M Bellet, Loredana Zocchi, Paolo Sassone-Corsi "}, {"type": "b", "children": [{"type": "t", "text": "The RelB subunit of NFκB acts as a negative regulator of circadian gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cc.21669"}], "href": "https://doi.org/10.4161/cc.21669"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22894897"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22894897"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Harald Jakob Maier, Ralf Marienfeld, Thomas Wirth, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Critical role of RelB serine 368 for dimerization and p100 stabilization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M301521200"}], "href": "https://doi.org/10.1074/jbc.M301521200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12874295"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12874295"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Lin Long, Xiao-Xiao Pang, Fei Lei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SLC52A3 expression is activated by NF-κB p65/Rel-B and serves as a prognostic biomarker in esophageal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-018-2757-4"}], "href": "https://doi.org/10.1007/s00018-018-2757-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29428966"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29428966"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Kathryn M Oliver, Colin R Lenihan, Ulrike Bruning, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypercapnia induces cleavage and nuclear localization of RelB protein, giving insight into CO2 sensing and signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.347971"}], "href": "https://doi.org/10.1074/jbc.M112.347971"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22396550"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22396550"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Bingbing Wang, Nataliya Parobchak, Todd Rosen "}, {"type": "b", "children": [{"type": "t", "text": "RelB/NF-κB2 regulates corticotropin-releasing hormone in the human placenta."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2012-1035"}], "href": "https://doi.org/10.1210/me.2012-1035"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22734038"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22734038"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Chiara Gasparini, Brian M Foxwell, Marc Feldmann "}, {"type": "b", "children": [{"type": "t", "text": "RelB/p50 regulates TNF production in LPS-stimulated dendritic cells and macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cytokine (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cyto.2012.12.029"}], "href": "https://doi.org/10.1016/j.cyto.2012.12.029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23394901"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23394901"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Jakub Siednienko, Ashwini Maratha, Shuo Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear factor κB subunits RelB and cRel negatively regulate Toll-like receptor 3-mediated β-interferon production via induction of transcriptional repressor protein YY1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.250894"}], "href": "https://doi.org/10.1074/jbc.M111.250894"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22065573"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22065573"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Alice C Newman, Alain J Kemp, Yvette Drabsch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Autophagy acts through TRAF3 and RELB to regulate gene expression via antagonism of SMAD proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-017-00859-z"}], "href": "https://doi.org/10.1038/s41467-017-00859-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29146913"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29146913"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Jingpu Zhang, Jie Tao, Yun Ling, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Switch of NAD Salvage to "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "de novo"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Biosynthesis Sustains SIRT1-RelB-Dependent Inflammatory Tolerance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2019.02358"}], "href": "https://doi.org/10.3389/fimmu.2019.02358"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31681271"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31681271"}]}]}]}
Synonyms I-REL, IREL, IMD53, REL-B
Proteins RELB_HUMAN
NCBI Gene ID 5971
API
Download Associations
Predicted Functions View RELB's ARCHS4 Predicted Functions.
Co-expressed Genes View RELB's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View RELB's ARCHS4 Predicted Functions.

Functional Associations

RELB has 14,002 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 118 datasets.

Click the + buttons to view associations for RELB from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles tissues with high or low expression of RELB gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles tissues with high or low expression of RELB gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray tissue samples with high or low expression of RELB gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq tissue samples with high or low expression of RELB gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles tissues with high or low expression of RELB gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
BioGPS Cell Line Gene Expression Profiles cell lines with high or low expression of RELB gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
BioGPS Human Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of RELB gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of RELB gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of RELB gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CCLE Cell Line Gene Expression Profiles cell lines with high or low expression of RELB gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
CCLE Cell Line Proteomics Cell lines associated with RELB protein from the CCLE Cell Line Proteomics dataset.
CellMarker Gene-Cell Type Associations cell types associated with RELB gene from the CellMarker Gene-Cell Type Associations dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of RELB gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of RELB gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ChEA Transcription Factor Targets 2022 transcription factors binding the promoter of RELB gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
CMAP Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of RELB gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores cellular components containing RELB protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 cellular components containing RELB protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Experimental Protein Localization Evidence Scores cellular components containing RELB protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores cellular components co-occuring with RELB protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with RELB protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
CORUM Protein Complexes protein complexs containing RELB protein from the CORUM Protein Complexes dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of RELB gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene Mutation Profiles cell lines with RELB gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
CTD Gene-Chemical Interactions chemicals interacting with RELB gene/protein from the curated CTD Gene-Chemical Interactions dataset.
CTD Gene-Disease Associations diseases associated with RELB gene/protein from the curated CTD Gene-Disease Associations dataset.
DeepCoverMOA Drug Mechanisms of Action small molecule perturbations with high or low expression of RELB protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
DepMap CRISPR Gene Dependency cell lines with fitness changed by RELB gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 diseases associated with RELB gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores diseases co-occuring with RELB gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with RELB gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
DisGeNET Gene-Disease Associations diseases associated with RELB gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
DisGeNET Gene-Phenotype Associations phenotypes associated with RELB gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at RELB gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of RELB gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of RELB gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells PubMedIDs of publications reporting gene signatures containing RELB from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
GAD Gene-Disease Associations diseases associated with RELB gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
GAD High Level Gene-Disease Associations diseases associated with RELB gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
GDSC Cell Line Gene Expression Profiles cell lines with high or low expression of RELB gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with RELB gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing RELB from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of RELB gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of RELB gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of RELB gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of RELB gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of RELB gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of RELB gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GO Biological Process Annotations 2015 biological processes involving RELB gene from the curated GO Biological Process Annotations 2015 dataset.
GO Biological Process Annotations 2023 biological processes involving RELB gene from the curated GO Biological Process Annotations 2023 dataset.
GO Biological Process Annotations 2025 biological processes involving RELB gene from the curated GO Biological Process Annotations2025 dataset.
GO Cellular Component Annotations 2015 cellular components containing RELB protein from the curated GO Cellular Component Annotations 2015 dataset.
GO Cellular Component Annotations 2023 cellular components containing RELB protein from the curated GO Cellular Component Annotations 2023 dataset.
GO Cellular Component Annotations 2025 cellular components containing RELB protein from the curated GO Cellular Component Annotations 2025 dataset.
GO Molecular Function Annotations 2015 molecular functions performed by RELB gene from the curated GO Molecular Function Annotations 2015 dataset.
GO Molecular Function Annotations 2023 molecular functions performed by RELB gene from the curated GO Molecular Function Annotations 2023 dataset.
GO Molecular Function Annotations 2025 molecular functions performed by RELB gene from the curated GO Molecular Function Annotations 2025 dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of RELB gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of RELB gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of RELB gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
GWASdb SNP-Disease Associations diseases associated with RELB gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.
GWASdb SNP-Phenotype Associations phenotypes associated with RELB gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles cell lines with high or low expression of RELB gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset.
HPA Cell Line Gene Expression Profiles cell lines with high or low expression of RELB gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset.
HPA Tissue Gene Expression Profiles tissues with high or low expression of RELB gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset.
HPA Tissue Protein Expression Profiles tissues with high or low expression of RELB protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset.
HPA Tissue Sample Gene Expression Profiles tissue samples with high or low expression of RELB gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset.
Hub Proteins Protein-Protein Interactions interacting hub proteins for RELB from the curated Hub Proteins Protein-Protein Interactions dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with RELB gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
InterPro Predicted Protein Domain Annotations protein domains predicted for RELB protein from the InterPro Predicted Protein Domain Annotations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of RELB gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
KEA Substrates of Kinases kinases that phosphorylate RELB protein from the curated KEA Substrates of Kinases dataset.
Kinase Library Serine Threonine Kinome Atlas kinases that phosphorylate RELB protein from the Kinase Library Serine Threonine Atlas dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of RELB gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of RELB gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles cell lines with RELB gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of RELB gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures small molecule perturbations changing expression of RELB gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset.
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures gene perturbations changing expression of RELB gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of RELB gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
LOCATE Curated Protein Localization Annotations cellular components containing RELB protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset.
LOCATE Predicted Protein Localization Annotations cellular components predicted to contain RELB protein from the LOCATE Predicted Protein Localization Annotations dataset.
MGI Mouse Phenotype Associations 2023 phenotypes of transgenic mice caused by RELB gene mutations from the MGI Mouse Phenotype Associations 2023 dataset.
MiRTarBase microRNA Targets microRNAs targeting RELB gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of RELB gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
MPO Gene-Phenotype Associations phenotypes of transgenic mice caused by RELB gene mutations from the MPO Gene-Phenotype Associations dataset.
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations gene perturbations changing expression of RELB gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles drug perturbations changing expression of RELB gene from the NIBR DRUG-seq U2OS MoA Box dataset.
NURSA Protein Complexes protein complexs containing RELB protein recovered by IP-MS from the NURSA Protein Complexes dataset.
PANTHER Pathways pathways involving RELB protein from the PANTHER Pathways dataset.
Pathway Commons Protein-Protein Interactions interacting proteins for RELB from the Pathway Commons Protein-Protein Interactions dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of RELB gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations gene perturbations changing expression of RELB gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PFOCR Pathway Figure Associations 2023 pathways involving RELB protein from the PFOCR Pathway Figure Associations 2023 dataset.
PFOCR Pathway Figure Associations 2024 pathways involving RELB protein from the Wikipathways PFOCR 2024 dataset.
Phosphosite Textmining Biological Term Annotations biological terms co-occuring with RELB protein in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.
PhosphoSitePlus Substrates of Kinases kinases that phosphorylate RELB protein from the curated PhosphoSitePlus Substrates of Kinases dataset.
PID Pathways pathways involving RELB protein from the PID Pathways dataset.
Reactome Pathways 2024 pathways involving RELB protein from the Reactome Pathways 2024 dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of RELB gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
Roadmap Epigenomics Cell and Tissue Gene Expression Profiles cell types and tissues with high or low expression of RELB gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at RELB gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of RELB gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of RELB gene from the RummaGEO Gene Perturbation Signatures dataset.
Sanger Dependency Map Cancer Cell Line Proteomics cell lines associated with RELB protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset.
SynGO Synaptic Gene Annotations synaptic terms associated with RELB gene from the SynGO Synaptic Gene Annotations dataset.
Tabula Sapiens Gene-Cell Associations cell types with high or low expression of RELB gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset.
Tahoe Therapeutics Tahoe 100M Perturbation Atlas drug perturbations changing expression of RELB gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
TargetScan Predicted Conserved microRNA Targets microRNAs regulating expression of RELB gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset.
TargetScan Predicted Nonconserved microRNA Targets microRNAs regulating expression of RELB gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of RELB gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores tissues with high expression of RELB protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 tissues with high expression of RELB protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores tissues with high expression of RELB protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores tissues co-occuring with RELB protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with RELB protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.
WikiPathways Pathways 2014 pathways involving RELB protein from the Wikipathways Pathways 2014 dataset.
WikiPathways Pathways 2024 pathways involving RELB protein from the WikiPathways Pathways 2024 dataset.