RGS10 Gene

HGNC Family	Regulators of G-protein signaling (RGS)
Name	regulator of G-protein signaling 10
Description	Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRGS10 functions as a critical negative regulator of G protein–coupled receptor signaling in ovarian cancer cells, where its down‐regulation—mediated by epigenetic mechanisms such as DNA hypermethylation and histone deacetylation—is associated with enhanced cell survival, chemoresistance, and activation of oncogenic pathways including mTOR signaling. In ovarian cancer models, reduced RGS10 levels lead to diminished termination of G protein signaling, thereby promoting cell proliferation and resistance to chemotherapeutics. In parallel, studies in colon adenocarcinoma similarly indicate that hypermethylation of the RGS10 promoter contributes to its suppressed expression in tumors, suggesting that targeting these epigenetic modifications might restore RGS10’s tumor‐suppressive functions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the immune system, RGS10 modulates inflammatory and adhesion responses in several cell types. In platelets, it is sequestered within a multiprotein complex that helps maintain quiescence by modulating thrombotic and antithrombotic signals. In T lymphocytes, RGS10 limits chemokine-induced integrin adhesion by countering the Vav1-Rac1 pathway, thereby tempering adhesion strengthening and cell spreading. Furthermore, loss of RGS10 in microglia leads to elevated expression of pro-inflammatory mediators such as TNFα and cyclooxygenase-2 independent of Gi protein activity, while rare mutations in RGS10 have been linked to impaired lymphocyte chemotaxis and immunodeficiency syndromes that also manifest in growth hormone deficiency. Emerging evidence even implicates RGS10’s anti-inflammatory functions in autoinflammatory conditions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of bone homeostasis, RGS10—specifically the RGS10A isoform—plays a vital role in osteoclast differentiation. RGS10A is induced by RANKL in osteoclast precursors, where it is required for the generation of intracellular calcium oscillations and subsequent NFAT2 activation, events essential for terminal osteoclast differentiation and survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in cancer and immune regulation, RGS10 is broadly expressed in the brain and other tissues, where it acts as a GTPase activating protein (GAP) that accelerates GTP hydrolysis on Gαi subunits. Structural studies have elucidated RGS10’s interactions with Gα proteins, and immunohistochemical analyses indicate that its subcellular localization may influence both neuronal signaling and the pathophysiology of neuropsychiatric disorders such as schizophrenia, although genetic studies yield mixed findings. Comprehensive reviews highlight RGS10’s multifaceted regulation—spanning transcriptional control, post-translational modifications, and protein-protein interactions—that underpin its role in modulating GPCR signaling across diverse physiological systems."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ercan Cacan, Mourad W Ali, Nathaniel H Boyd, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of HDAC1 and DNMT1 modulate RGS10 expression and decrease ovarian cancer chemoresistance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0087455"}], "href": "https://doi.org/10.1371/journal.pone.0087455"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24475290"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24475290"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Shelley B Hooks, Phillip Callihan, Molly K Altman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulators of G-Protein signaling RGS10 and RGS17 regulate chemoresistance in ovarian cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1476-4598-9-289"}], "href": "https://doi.org/10.1186/1476-4598-9-289"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21044322"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21044322"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Molly K Altman, Ali A Alshamrani, Wei Jia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Suppression of the GTPase-activating protein RGS10 increases Rheb-GTP and mTOR signaling in ovarian cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2015.08.012"}], "href": "https://doi.org/10.1016/j.canlet.2015.08.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26319900"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26319900"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Shelley B Hooks, Mandi M Murph "}, {"type": "b", "children": [{"type": "t", "text": "Cellular deficiency in the RGS10 protein facilitates chemoresistant ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Future Med Chem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4155/fmc.15.81"}], "href": "https://doi.org/10.4155/fmc.15.81"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26293348"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26293348"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Burak Kucuk, Beyza Kibar, Ercan Cacan "}, {"type": "b", "children": [{"type": "t", "text": "A broad analysis in clinical and in vitro models on regulator of G-protein signalling 10 regulation that is associated with ovarian cancer progression and chemoresistance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biochem Funct (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cbf.3607"}], "href": "https://doi.org/10.1002/cbf.3607"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33354811"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33354811"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Feyzanur Yildirimtepe Caldiran, Ercan Cacan "}, {"type": "b", "children": [{"type": "t", "text": "RGS10 suppression by DNA methylation is associated with low survival rates in colorectal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2022.154007"}], "href": "https://doi.org/10.1016/j.prp.2022.154007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35810565"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35810565"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Peisong Ma, Aleksandra Cierniewska, Rachel Signarvic, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Short stature and combined immunodeficiency associated with mutations in RGS10."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.abc1940"}], "href": "https://doi.org/10.1126/scisignal.abc1940"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34315806"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34315806"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Feyzanur Caldiran, Koksal Deveci, Ercan Cacan "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic insights into Familial Mediterranean Fever: Increased RGS10 expression and histone modifications accompanies inflammation in familial Mediterranean fever disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2024.148222"}], "href": "https://doi.org/10.1016/j.gene.2024.148222"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38331118"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38331118"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Shuying Yang, Wei Chen, Philip Stashenko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Specificity of RGS10A as a key component in the RANKL signaling mechanism for osteoclast differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.008300"}], "href": "https://doi.org/10.1242/jcs.008300"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17881498"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17881498"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "G Rivero, A M Gabilondo, J A García-Sevilla, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Brain RGS4 and RGS10 protein expression in schizophrenia and depression. Effect of drug treatment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Psychopharmacology (Berl) (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00213-012-2888-5"}], "href": "https://doi.org/10.1007/s00213-012-2888-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23093381"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23093381"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Faris Almutairi, Jae-Kyung Lee, Balázs Rada "}, {"type": "b", "children": [{"type": "t", "text": "Regulator of G protein signaling 10: Structure, expression and functions in cellular physiology and diseases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2020.109765"}], "href": "https://doi.org/10.1016/j.cellsig.2020.109765"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32882407"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32882407"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Akitoyo Hishimoto, Osamu Shirakawa, Naoki Nishiguchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel missense polymorphism in the regulator of G-protein signaling 10 gene: analysis of association with schizophrenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Psychiatry Clin Neurosci (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1440-1819.2004.01303.x"}], "href": "https://doi.org/10.1111/j.1440-1819.2004.01303.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15482592"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15482592"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Guadalupe Rivero, Ane M Gabilondo, Jesús A García-Sevilla, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of regulators of G-protein signaling RGS4 and RGS10 proteins in the postmortem human brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurochem Int (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuint.2010.08.008"}], "href": "https://doi.org/10.1016/j.neuint.2010.08.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20816714"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20816714"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Hyung Ki Lee, Kyung Hee Rhee, Chan Wha Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Crystallization and preliminary X-ray crystallographic analysis of human RGS10 complexed with Galphai3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Crystallogr Sect F Struct Biol Cryst Commun (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1107/S1744309105023602"}], "href": "https://doi.org/10.1107/S1744309105023602"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16511171"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16511171"}]}]}]}
Proteins	RGS10_HUMAN
NCBI Gene ID	6001
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RGS10 has 8,921 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 128 datasets.

Click the + buttons to view associations for RGS10 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RGS10 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RGS10 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of RGS10 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of RGS10 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of RGS10 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RGS10 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RGS10 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RGS10 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RGS10 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RGS10 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of RGS10 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RGS10 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of RGS10 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with RGS10 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with RGS10 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RGS10 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RGS10 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RGS10 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RGS10 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RGS10 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing RGS10 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing RGS10 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing RGS10 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RGS10 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RGS10 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RGS10 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RGS10 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with RGS10 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with RGS10 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by RGS10 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with RGS10 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RGS10 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RGS10 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RGS10 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RGS10 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RGS10 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RGS10 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of RGS10 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing RGS10 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with RGS10 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with RGS10 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.