RGS7 Gene

HGNC Family	Regulators of G-protein signaling (RGS)
Name	regulator of G-protein signaling 7
Description	Enables G-protein alpha-subunit binding activity; G-protein beta-subunit binding activity; and GTPase activator activity. Involved in G protein-coupled receptor signaling pathway; negative regulation of G protein-coupled receptor signaling pathway; and positive regulation of GTPase activity. Located in cytosol. Is active in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRGS7, a member of the R7 family of regulators of G protein signaling, is a multifunctional protein that accelerates GTP hydrolysis on Gα subunits and thereby modulates the kinetics of GPCR signaling. In neurons, RGS7 forms obligate heterotrimeric complexes with Gβ5 and accessory proteins such as R7BP, whose reversible palmitoylation governs subcellular trafficking between the plasma membrane and the nucleus, a process that is critical for optimal GAP activity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " In addition, phosphorylation events—for example, at serine 434—regulate its interaction with inhibitory 14-3-3 proteins, thereby dynamically modulating its ability to deactivate G protein signals."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Its discrete structural domains, including the DEP region, mediate selective interactions with receptors, as seen in the negative regulation of M3 muscarinic receptor signaling and the binding to the synaptic protein snapin, which implicates RGS7 in synaptic vesicle exocytosis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", while proper complex assembly is facilitated by cytosolic chaperones such as CCT and PhLP1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nHigh-resolution structural and cellular studies have further refined our understanding of RGS7’s organization and receptor interactions. In striatal neurons, RGS7 selectively regulates GPCRs—such as μ-opioid and dopamine D2 receptors—through bias toward Go signaling, a function that is enhanced in the presence of R7BP."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Recent cryo–electron microscopy and crystallographic analyses have revealed the architecture of complexes formed between RGS7 and atypical orphan receptors such as GPR158, delineating how intracellular loops of GPCRs engage RGS7–Gβ5 assemblies to terminate Gαi/o signaling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "11"}]}, {"type": "t", "text": " Moreover, RGS7 has been shown to form homo‐oligomers through interactions involving its DEP domain—a self‐association that is modulated by binding partners like R7BP and GPR158 and that may expand its influence over processes such as neurite morphogenesis via crosstalk with Gα13 and RhoGEF signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its classical role in neuronal GPCR regulation, RGS7 has emerged as a key player in diverse physiological and pathological contexts. Genetic variations in the RGS7 locus have been linked to altered platelet reactivity in diabetic patients"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "and modestly to susceptibility to panic disorder—with effects that appear to be gender‐specific—as well as to predisposition for uterine fibroids."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": " In cancer, loss‐of‐function mutations in RGS7, such as the recurrent p.R44C variant in melanoma, underscore its tumor‐suppressive role."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": " Moreover, in non‐neuronal tissues, aberrant upregulation of RGS7 has been implicated in cardiomyocyte oxidative stress, inflammation, and chemotherapeutic drug–induced cardiotoxicity through its interaction with CaMKII and modulation of NF‑κB signaling via Tip60/SIRT1, as well as in pancreatic β‑cell injury via activation of the chemokine signaling pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": " Finally, preliminary genetic association studies suggest that variants near RGS7 may contribute to multiple sclerosis susceptibility"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": "and affect the pathogenesis of uterine leiomyomas."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ryan M Drenan, Craig A Doupnik, Muralidharan Jayaraman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "R7BP augments the function of RGS7*Gbeta5 complexes by a plasma membrane-targeting mechanism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M604428200"}], "href": "https://doi.org/10.1074/jbc.M604428200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16867977"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16867977"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Satoshi Takida, Christopher C Fischer, Philip B Wedegaertner "}, {"type": "b", "children": [{"type": "t", "text": "Palmitoylation and plasma membrane targeting of RGS7 are promoted by alpha o."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Pharmacol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/mol.104.003418"}], "href": "https://doi.org/10.1124/mol.104.003418"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15496508"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15496508"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lixia Jia, Maurine E Linder, Kendall J Blumer "}, {"type": "b", "children": [{"type": "t", "text": "Gi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.193763"}], "href": "https://doi.org/10.1074/jbc.M110.193763"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21343290"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21343290"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Thomas Benzing, Michael Köttgen, Marc Johnson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction of 14-3-3 protein with regulator of G protein signaling 7 is dynamically regulated by tumor necrosis factor-alpha."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M200859200"}], "href": "https://doi.org/10.1074/jbc.M200859200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12077120"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12077120"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Simone L Sandiford, Vladlen Z Slepak "}, {"type": "b", "children": [{"type": "t", "text": "The Gbeta5-RGS7 complex selectively inhibits muscarinic M3 receptor signaling via the interaction between the third intracellular loop of the receptor and the DEP domain of RGS7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi801989c"}], "href": "https://doi.org/10.1021/bi801989c"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19182865"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19182865"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Rachel A Hunt, Wade Edris, Pranab K Chanda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Snapin interacts with the N-terminus of regulator of G protein signaling 7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0006-291x(03)00400-5"}], "href": "https://doi.org/10.1016/s0006-291x(03"}, {"type": "t", "text": "00400-5) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12659861"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12659861"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Alyson C Howlett, Amy J Gray, Jesse M Hunter, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of molecular chaperones in G protein beta5/regulator of G protein signaling dimer assembly and G protein betagamma dimer specificity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M900800200"}], "href": "https://doi.org/10.1074/jbc.M900800200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19376773"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19376773"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Ikuo Masuho, Keqiang Xie, Kirill A Martemyanov "}, {"type": "b", "children": [{"type": "t", "text": "Macromolecular composition dictates receptor and G protein selectivity of regulator of G protein signaling (RGS) 7 and 9-2 protein complexes in living cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.462283"}], "href": "https://doi.org/10.1074/jbc.M113.462283"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23857581"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23857581"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Dipak N Patil, Shikha Singh, Thibaut Laboute, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Structural organization of a major neuronal G protein regulator, the RGS7-Gβ5-R7BP complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.42150"}], "href": "https://doi.org/10.7554/eLife.42150"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30540250"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30540250"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Eunyoung Jeong, Yoojoong Kim, Jihong Jeong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure of the class C orphan GPCR GPR158 in complex with RGS7-Gβ5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-021-27147-1"}], "href": "https://doi.org/10.1038/s41467-021-27147-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34815401"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34815401"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Junior Tayou, Qiang Wang, Geeng-Fu Jang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulator of G Protein Signaling 7 (RGS7) Can Exist in a Homo-oligomeric Form That Is Regulated by Gαo and R7-binding Protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M115.694075"}], "href": "https://doi.org/10.1074/jbc.M115.694075"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26895961"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26895961"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Stephanie L Scherer, Matthew D Cain, Stanley M Kanai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of neurite morphogenesis by interaction between R7 regulator of G protein signaling complexes and G protein subunit Gα"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "13"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": "."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M116.771923"}], "href": "https://doi.org/10.1074/jbc.M116.771923"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28432124"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28432124"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Marek Postula, Piotr K Janicki, Marek Rosiak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "New single nucleotide polymorphisms associated with differences in platelets reactivity in patients with type 2 diabetes treated with acetylsalicylic acid: genome-wide association approach and pooled DNA strategy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Thromb Thrombolysis (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11239-012-0823-6"}], "href": "https://doi.org/10.1007/s11239-012-0823-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23054467"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23054467"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Christa Hohoff, Anna Neumann, Katharina Domschke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association analysis of Rgs7 variants with panic disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neural Transm (Vienna) (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00702-008-0097-5"}], "href": "https://doi.org/10.1007/s00702-008-0097-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18762858"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18762858"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Brahim Aissani, Kui Zhang, Arjen R Mensenkamp, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fine mapping of the uterine leiomyoma locus on 1q43 close to a lncRNA in the RGS7-FH interval."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocr Relat Cancer (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1530/ERC-15-0208"}], "href": "https://doi.org/10.1530/ERC-15-0208"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26113603"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26113603"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Nouar Qutob, Ikuo Masuho, Michal Alon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-017-18851-4"}], "href": "https://doi.org/10.1038/s41598-017-18851-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29330521"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29330521"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Madhuri Basak, Abhishek Singh Sengar, Kiran Das, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A RGS7-CaMKII complex drives myocyte-intrinsic and myocyte-extrinsic mechanisms of chemotherapy-induced cardiotoxicity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.2213537120"}], "href": "https://doi.org/10.1073/pnas.2213537120"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36574707"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36574707"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Yurong Zhu, Jun Li, Tao Ba, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RGS7 silence protects palmitic acid-induced pancreatic β-cell injury by inactivating the chemokine signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autoimmunity (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/08916934.2023.2194584"}], "href": "https://doi.org/10.1080/08916934.2023.2194584"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36999276"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36999276"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "J L McCauley, R L Zuvich, Y Bradford, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Immun (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/gene.2009.53"}], "href": "https://doi.org/10.1038/gene.2009.53"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19626040"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19626040"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Madhuri Basak, Kiran Das, Tarun Mahata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RGS7 balances acetylation/de-acetylation of p65 to control chemotherapy-dependent cardiac inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-023-04895-5"}], "href": "https://doi.org/10.1007/s00018-023-04895-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37589751"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37589751"}]}]}]}
Proteins	RGS7_HUMAN
NCBI Gene ID	6000
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RGS7 has 4,971 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 120 datasets.

Click the + buttons to view associations for RGS7 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RGS7 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RGS7 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of RGS7 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of RGS7 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of RGS7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RGS7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RGS7 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RGS7 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RGS7 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RGS7 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of RGS7 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RGS7 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of RGS7 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with RGS7 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RGS7 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RGS7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RGS7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of RGS7 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RGS7 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RGS7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing RGS7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing RGS7 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RGS7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RGS7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RGS7 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RGS7 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with RGS7 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with RGS7 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with RGS7 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by RGS7 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RGS7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RGS7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RGS7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RGS7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RGS7 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RGS7 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of RGS7 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing RGS7 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with RGS7 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with RGS7 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of RGS7 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.