RHCG Gene

HGNC Family Solute carriers (SLC)
Name Rh family, C glycoprotein
Description Enables several functions, including ammonium channel activity; ankyrin binding activity; and carbon dioxide transmembrane transporter activity. Involved in ammonium transmembrane transport; intracellular monoatomic ion homeostasis; and transepithelial ammonium transport. Located in apical plasma membrane and basolateral plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nHuman RHCG forms a trimeric complex that functions as a crucial ammonia channel. High‐resolution structural studies have revealed that each monomer contains 12 transmembrane helices, with an extended pore architecture optimized for NH3 transport, a process essential to ammonia excretion and renal pH regulation. Functional investigations in kidney and other epithelial cells demonstrated that RHCG facilitates fast, low‐energy–dependent, bi‐directional movement of ammonia, a capacity that is evident when the purified protein is reconstituted in proteoliposomes and when expressed in heterologous systems. In addition, in airway epithelia, RHCG shows apical localization and operates through a saturable mechanism to regulate NH3 flux."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMolecular investigations have further refined our understanding of RHCG’s transport mechanism. Studies using heterologous expression systems corroborate that RHCG mediates the passage of both NH3 and NH4+, with precise subcellular localization in human renal epithelia suggesting predominant apical expression. Computational approaches, including molecular dynamics and quantum mechanical simulations, indicate that conserved residues such as the signature histidine and specific pore-lining phenylalanines contribute to a mechanism in which NH4+ is recruited and deprotonated to yield NH3 that subsequently diffuses through the channel. Moreover, RHCG appears functionally integrated with proton-ATPase complexes in renal intercalated cells, potentially modulating urinary acidification. Site-directed mutagenesis has identified key amino acid residues required for optimal NH3 flux across membranes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in gas transport, RHCG has emerged as a critical player in cancer biology. In esophageal squamous cell carcinoma, cervical cancer, and head and neck squamous cell carcinoma, downregulation of RHCG is associated with aggressive tumor features, including poor differentiation, enhanced invasion, and metastasis, suggesting a tumor-suppressive function. Mechanistic studies indicate that RHCG can stabilize inhibitory proteins (such as IκB), thereby preventing NF-κB activation, and modulate the expression of matrix metalloproteinases and other signaling effectors to impede cancer cell proliferation and motility. Conversely, in gastric adenocarcinoma, elevated RHCG expression correlates with adverse clinicopathological parameters including high HER-2 levels and poor prognosis, highlighting its complex, tissue-specific role in tumor progression and signaling modulation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Franz Gruswitz, Sarika Chaudhary, Joseph D Ho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Function of human Rh based on structure of RhCG at 2.1 A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1003587107"}], "href": "https://doi.org/10.1073/pnas.1003587107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20457942"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20457942"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Nedjma Zidi-Yahiaoui, Isabelle Mouro-Chanteloup, Anne-Marie D'Ambrosio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human Rhesus B and Rhesus C glycoproteins: properties of facilitated ammonium transport in recombinant kidney cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20050657"}], "href": "https://doi.org/10.1042/BJ20050657"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15929723"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15929723"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "I David Weiner, Jill W Verlander "}, {"type": "b", "children": [{"type": "t", "text": "Ammonia transport in the kidney by Rhesus glycoproteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Renal Physiol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajprenal.00013.2014"}], "href": "https://doi.org/10.1152/ajprenal.00013.2014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24647713"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24647713"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Isabelle Mouro-Chanteloup, Sylvie Cochet, Mohamed Chami, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional reconstitution into liposomes of purified human RhCG ammonia channel."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0008921"}], "href": "https://doi.org/10.1371/journal.pone.0008921"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20126667"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20126667"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ki-Hwan Han, Kavya Mekala, Venetia Babida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of the gas-transporting proteins, Rh B glycoprotein and Rh C glycoprotein, in the murine lung."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Lung Cell Mol Physiol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajplung.90524.2008"}], "href": "https://doi.org/10.1152/ajplung.90524.2008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19429772"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19429772"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "R Ryan Geyer, Mark D Parker, Ashley M Toye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Relative CO₂/NH₃ permeabilities of human RhAG, RhBG and RhCG."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Membr Biol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00232-013-9593-0"}], "href": "https://doi.org/10.1007/s00232-013-9593-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24077989"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24077989"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "N Bakouh, F Benjelloun, B Cherif-Zahar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The challenge of understanding ammonium homeostasis and the role of the Rh glycoproteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transfus Clin Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.tracli.2006.02.008"}], "href": "https://doi.org/10.1016/j.tracli.2006.02.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16564724"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16564724"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Alice C N Brown, Dalila Hallouane, William J Mawby, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RhCG is the major putative ammonia transporter expressed in the human kidney, and RhBG is not expressed at detectable levels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Renal Physiol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajprenal.00013.2009"}], "href": "https://doi.org/10.1152/ajprenal.00013.2009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19357182"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19357182"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Sefer Baday, Esam A Orabi, Shihao Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mechanism of NH4(+) Recruitment and NH3 Transport in Rh Proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Structure (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.str.2015.06.010"}], "href": "https://doi.org/10.1016/j.str.2015.06.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26190573"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26190573"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Soline Bourgeois, Lisa Bounoure, Isabelle Mouro-Chanteloup, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The ammonia transporter RhCG modulates urinary acidification by interacting with the vacuolar proton-ATPases in renal intercalated cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Kidney Int (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.kint.2017.07.027"}], "href": "https://doi.org/10.1016/j.kint.2017.07.027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29054531"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29054531"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Sefer Baday, Shihao Wang, Guillaume Lamoureux, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Different hydration patterns in the pores of AmtB and RhCG could determine their transport mechanisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi400015f"}], "href": "https://doi.org/10.1021/bi400015f"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24021113"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24021113"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "N Zidi-Yahiaoui, P Ripoche, C Le Van Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ammonium transport properties of HEK293 cells expressing RhCG mutants: preliminary analysis of structure/function by site-directed mutagenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transfus Clin Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.tracli.2006.02.025"}], "href": "https://doi.org/10.1016/j.tracli.2006.02.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16580862"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16580862"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Xiao-Yan Ming, Xu Zhang, Ting-Ting Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RHCG Suppresses Tumorigenicity and Metastasis in Esophageal Squamous Cell Carcinoma via Inhibiting NF-κB Signaling and MMP1 Expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Theranostics (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/thno.21383"}], "href": "https://doi.org/10.7150/thno.21383"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29290801"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29290801"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Dong-Ge Wang, Tong-Min Li, Xuan Liu "}, {"type": "b", "children": [{"type": "t", "text": "RHCG suppresses cervical cancer progression through inhibiting migration and inducing apoptosis regulated by TGF-β1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.05.183"}], "href": "https://doi.org/10.1016/j.bbrc.2018.05.183"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29852177"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29852177"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Wenguang Xu, Huihui Zou, Zheng Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rh type C-glycoprotein functions as a novel tumor suppressor gene by inhibiting tumorigenicity and metastasis in head and neck squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.102000"}], "href": "https://doi.org/10.18632/aging.102000"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31170090"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31170090"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Pei Chen, Can Liu, Peng Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High RhCG expression predicts poor survival and promotes migration and proliferation of gastric cancer via keeping intracellular alkaline."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2019.111740"}], "href": "https://doi.org/10.1016/j.yexcr.2019.111740"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31756312"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31756312"}]}]}]}
Synonyms C15ORF6, RHGK, PDRC2, SLC42A3
Proteins RHCG_HUMAN
NCBI Gene ID 51458
API
Download Associations
Predicted Functions View RHCG's ARCHS4 Predicted Functions.
Co-expressed Genes View RHCG's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View RHCG's ARCHS4 Predicted Functions.

Functional Associations

RHCG has 5,319 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 102 datasets.

Click the + buttons to view associations for RHCG from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles tissues with high or low expression of RHCG gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles tissues with high or low expression of RHCG gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray tissue samples with high or low expression of RHCG gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq tissue samples with high or low expression of RHCG gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles tissues with high or low expression of RHCG gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
BioGPS Cell Line Gene Expression Profiles cell lines with high or low expression of RHCG gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
BioGPS Human Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of RHCG gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of RHCG gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of RHCG gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CCLE Cell Line Gene Expression Profiles cell lines with high or low expression of RHCG gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
CellMarker Gene-Cell Type Associations cell types associated with RHCG gene from the CellMarker Gene-Cell Type Associations dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of RHCG gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of RHCG gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ChEA Transcription Factor Targets 2022 transcription factors binding the promoter of RHCG gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
CMAP Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of RHCG gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores cellular components containing RHCG protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 cellular components containing RHCG protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores cellular components co-occuring with RHCG protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with RHCG protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of RHCG gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene Mutation Profiles cell lines with RHCG gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
CTD Gene-Chemical Interactions chemicals interacting with RHCG gene/protein from the curated CTD Gene-Chemical Interactions dataset.
CTD Gene-Disease Associations diseases associated with RHCG gene/protein from the curated CTD Gene-Disease Associations dataset.
DepMap CRISPR Gene Dependency cell lines with fitness changed by RHCG gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 diseases associated with RHCG gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores diseases co-occuring with RHCG gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with RHCG gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
DisGeNET Gene-Disease Associations diseases associated with RHCG gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
DisGeNET Gene-Phenotype Associations phenotypes associated with RHCG gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at RHCG gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of RHCG gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of RHCG gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells PubMedIDs of publications reporting gene signatures containing RHCG from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
GAD Gene-Disease Associations diseases associated with RHCG gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
GAD High Level Gene-Disease Associations diseases associated with RHCG gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
GDSC Cell Line Gene Expression Profiles cell lines with high or low expression of RHCG gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with RHCG gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing RHCG from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of RHCG gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of RHCG gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of RHCG gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of RHCG gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of RHCG gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of RHCG gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GO Biological Process Annotations 2015 biological processes involving RHCG gene from the curated GO Biological Process Annotations 2015 dataset.
GO Biological Process Annotations 2023 biological processes involving RHCG gene from the curated GO Biological Process Annotations 2023 dataset.
GO Biological Process Annotations 2025 biological processes involving RHCG gene from the curated GO Biological Process Annotations2025 dataset.
GO Cellular Component Annotations 2015 cellular components containing RHCG protein from the curated GO Cellular Component Annotations 2015 dataset.
GO Cellular Component Annotations 2023 cellular components containing RHCG protein from the curated GO Cellular Component Annotations 2023 dataset.
GO Cellular Component Annotations 2025 cellular components containing RHCG protein from the curated GO Cellular Component Annotations 2025 dataset.
GO Molecular Function Annotations 2015 molecular functions performed by RHCG gene from the curated GO Molecular Function Annotations 2015 dataset.
GO Molecular Function Annotations 2023 molecular functions performed by RHCG gene from the curated GO Molecular Function Annotations 2023 dataset.
GO Molecular Function Annotations 2025 molecular functions performed by RHCG gene from the curated GO Molecular Function Annotations 2025 dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of RHCG gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of RHCG gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of RHCG gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
Guide to Pharmacology Chemical Ligands of Receptors ligands (chemical) binding RHCG receptor from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.
GWASdb SNP-Phenotype Associations phenotypes associated with RHCG gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles cell lines with high or low expression of RHCG gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset.
HMDB Metabolites of Enzymes interacting metabolites for RHCG protein from the curated HMDB Metabolites of Enzymes dataset.
HPA Cell Line Gene Expression Profiles cell lines with high or low expression of RHCG gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset.
HPA Tissue Gene Expression Profiles tissues with high or low expression of RHCG gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset.
HPA Tissue Protein Expression Profiles tissues with high or low expression of RHCG protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset.
HPA Tissue Sample Gene Expression Profiles tissue samples with high or low expression of RHCG gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset.
HuBMAP Azimuth Cell Type Annotations cell types associated with RHCG gene from the HuBMAP Azimuth Cell Type Annotations dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with RHCG gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
InterPro Predicted Protein Domain Annotations protein domains predicted for RHCG protein from the InterPro Predicted Protein Domain Annotations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of RHCG gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of RHCG gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles cell lines with RHCG gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of RHCG gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures small molecule perturbations changing expression of RHCG gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset.
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures gene perturbations changing expression of RHCG gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of RHCG gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
LOCATE Curated Protein Localization Annotations cellular components containing RHCG protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset.
LOCATE Predicted Protein Localization Annotations cellular components predicted to contain RHCG protein from the LOCATE Predicted Protein Localization Annotations dataset.
MGI Mouse Phenotype Associations 2023 phenotypes of transgenic mice caused by RHCG gene mutations from the MGI Mouse Phenotype Associations 2023 dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of RHCG gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
MPO Gene-Phenotype Associations phenotypes of transgenic mice caused by RHCG gene mutations from the MPO Gene-Phenotype Associations dataset.
MSigDB Cancer Gene Co-expression Modules co-expressed genes for RHCG from the MSigDB Cancer Gene Co-expression Modules dataset.
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations gene perturbations changing expression of RHCG gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles drug perturbations changing expression of RHCG gene from the NIBR DRUG-seq U2OS MoA Box dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of RHCG gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations gene perturbations changing expression of RHCG gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PFOCR Pathway Figure Associations 2023 pathways involving RHCG protein from the PFOCR Pathway Figure Associations 2023 dataset.
PFOCR Pathway Figure Associations 2024 pathways involving RHCG protein from the Wikipathways PFOCR 2024 dataset.
Reactome Pathways 2014 pathways involving RHCG protein from the Reactome Pathways dataset.
Reactome Pathways 2024 pathways involving RHCG protein from the Reactome Pathways 2024 dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of RHCG gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at RHCG gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of RHCG gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of RHCG gene from the RummaGEO Gene Perturbation Signatures dataset.
Tabula Sapiens Gene-Cell Associations cell types with high or low expression of RHCG gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset.
TargetScan Predicted Conserved microRNA Targets microRNAs regulating expression of RHCG gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset.
TargetScan Predicted Nonconserved microRNA Targets microRNAs regulating expression of RHCG gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of RHCG gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores tissues with high expression of RHCG protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 tissues with high expression of RHCG protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores tissues with high expression of RHCG protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 tissues with high expression of RHCG protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores tissues co-occuring with RHCG protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with RHCG protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.