| Name | RIC3 acetylcholine receptor chaperone |
| Description | This gene encodes a member of the resistance to inhibitors of cholinesterase 3-like family which functions as a chaperone of specific 5-hydroxytryptamine type 3 receptor and nicotinic acetylcholine receptor subtypes. The encoded protein influences the folding and assembly of these receptor subunits in the endoplasmic reticulum and expression on the cell surface. This protein contains an N-terminal transmembrane domain, a proline-rich spacer, and a cytosolic C-terminal coiled-coil domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRIC‑3 is a conserved transmembrane chaperone that plays a crucial role in the folding, assembly, and trafficking of ligand‐gated ion channels. Early studies in Caenorhabditis elegans demonstrated that the ric‑3 gene is indispensable for the maturation of several nicotinic acetylcholine receptors (nAChRs), a function that is maintained in vertebrates. Subsequent experiments using Xenopus oocytes and mammalian cell lines confirmed that the human homolog of RIC‑3 enhances the functional expression of nAChRs—most notably the homomeric α7 subtype—by facilitating receptor folding and assembly. In addition, RIC‑3 has been shown to exert subtype‐specific effects, promoting surface expression and increasing mature receptor numbers in some cases while inhibiting the export of other heteromeric receptors (such as α4β2 and α3β4 nAChRs) and even certain 5‑HT₃ serotonin receptors. Detailed structure–function analyses reveal that RIC‑3’s activity depends on the integrity of its two transmembrane segments, coiled‑coil domain, and other cytoplasmic regions, and that alternative splicing in species like Drosophila further modulates its chaperone activity. These findings have been substantiated by studies employing electrophysiological recordings, receptor binding assays, and biochemical interaction methods that together establish RIC‑3 as a key regulator of receptor biogenesis and membrane targeting."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond this foundational role in receptor biogenesis, RIC‑3 function is modulated by complex regulatory mechanisms that include alternative splicing and genetic variation, which in turn can have significant implications for cell signaling and disease. For example, specific exonic deletions or missense variants have been found to alter RIC‑3’s interaction with receptor subunits, thereby shifting the balance between receptor upregulation and inhibition. In immune cells and astrocytes, such regulatory modifications can influence cholinergic signaling and the anti‑inflammatory actions mediated by α7 nAChRs. Moreover, genetic association studies have explored links between RIC‑3 variants and conditions such as Parkinson’s disease and obesity—even though the results have been inconsistent—highlighting the clinical interest in this protein’s regulatory versatility. Collectively, these advanced studies underscore RIC‑3’s multifaceted role as a fine‑tuner of receptor assembly and trafficking, and point to its potential as a therapeutic target in neuroinflammatory and neurodegenerative disorders."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "23"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sarah Halevi, Lina Yassin, Margalit Eshel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Conservation within the RIC-3 gene family. Effectors of mammalian nicotinic acetylcholine receptor expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M300170200"}], "href": "https://doi.org/10.1074/jbc.M300170200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12821669"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12821669"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mark E Williams, Bill Burton, Arturo Urrutia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ric-3 promotes functional expression of the nicotinic acetylcholine receptor alpha7 subunit in mammalian cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M410039200"}], "href": "https://doi.org/10.1074/jbc.M410039200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15504725"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15504725"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Aixin Cheng, Neil A McDonald, Christopher N Connolly "}, {"type": "b", "children": [{"type": "t", "text": "Cell surface expression of 5-hydroxytryptamine type 3 receptors is promoted by RIC-3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M414341200"}], "href": "https://doi.org/10.1074/jbc.M414341200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15809299"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15809299"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Mar Castillo, José Mulet, Luis M Gutiérrez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dual role of the RIC-3 protein in trafficking of serotonin and nicotinic acetylcholine receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M503746200"}], "href": "https://doi.org/10.1074/jbc.M503746200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15927954"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15927954"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Mar Castillo, José Mulet, Luis M Gutiérrez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of the RIC-3 protein in trafficking of serotonin and nicotinic acetylcholine receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Neurosci (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1385/JMN:30:1:153"}], "href": "https://doi.org/10.1385/JMN:30:1:153"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17192664"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17192664"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Aixin Cheng, Karen A Bollan, Sam M Greenwood, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential subcellular localization of RIC-3 isoforms and their role in determining 5-HT3 receptor composition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M703899200"}], "href": "https://doi.org/10.1074/jbc.M703899200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17609200"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17609200"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Francisco Castelán, Mar Castillo, José Mulet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular characterization and localization of the RIC-3 protein, an effector of nicotinic acetylcholine receptor expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurochem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1471-4159.2007.05169.x"}], "href": "https://doi.org/10.1111/j.1471-4159.2007.05169.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18179477"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18179477"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Stuart J Lansdell, Toby Collins, Arisa Yabe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Host-cell specific effects of the nicotinic acetylcholine receptor chaperone RIC-3 revealed by a comparison of human and Drosophila RIC-3 homologues."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurochem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1471-4159.2008.05235.x"}], "href": "https://doi.org/10.1111/j.1471-4159.2008.05235.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18208544"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18208544"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "N S Millar "}, {"type": "b", "children": [{"type": "t", "text": "RIC-3: a nicotinic acetylcholine receptor chaperone."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Pharmacol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.bjp.0707661"}], "href": "https://doi.org/10.1038/sj.bjp.0707661"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18246096"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18246096"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Renza Roncarati, Tamara Seredenina, Brian Jow, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional properties of alpha7 nicotinic acetylcholine receptors co-expressed with RIC-3 in a stable recombinant CHO-K1 cell line."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Assay Drug Dev Technol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/adt.2007.120"}], "href": "https://doi.org/10.1089/adt.2007.120"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18471073"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18471073"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jutta Walstab, Christian Hammer, Felix Lasitschka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RIC-3 exclusively enhances the surface expression of human homomeric 5-hydroxytryptamine type 3A (5-HT3A) receptors despite direct interactions with 5-HT3A, -C, -D, and -E subunits."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.122838"}], "href": "https://doi.org/10.1074/jbc.M110.122838"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20522555"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20522555"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Hayley M Bennett, Kristin Lees, Kate M Harper, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Xenopus laevis RIC-3 enhances the functional expression of the C. elegans homomeric nicotinic receptor, ACR-16, in Xenopus oocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurochem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jnc.12013"}], "href": "https://doi.org/10.1111/jnc.12013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22970690"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22970690"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Alejandro Dau, Pragya Komal, Mimi Truong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RIC-3 differentially modulates α4β2 and α7 nicotinic receptor assembly, expression, and nicotine-induced receptor upregulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Neurosci (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2202-14-47"}], "href": "https://doi.org/10.1186/1471-2202-14-47"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23586521"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23586521"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Matthew J Mulcahy, Sydney B Blattman, Francisco J Barrantes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Resistance to Inhibitors of Cholinesterase 3 (Ric-3) Expression Promotes Selective Protein Associations with the Human α7-Nicotinic Acetylcholine Receptor Interactome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0134409"}], "href": "https://doi.org/10.1371/journal.pone.0134409"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26258666"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26258666"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Akash Pandhare, Petar N Grozdanov, Michaela Jansen "}, {"type": "b", "children": [{"type": "t", "text": "Pentameric quaternary structure of the intracellular domain of serotonin type 3A receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep23921"}], "href": "https://doi.org/10.1038/srep23921"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27045630"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27045630"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Meliha Koldemir, Cigdem Kahveci, Hikmet Bayer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Relationship of RIC-3 gene rs1528133 polymorphism with varying degrees of body weight and eating behavior."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes Metab Syndr (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.dsx.2012.08.001"}], "href": "https://doi.org/10.1016/j.dsx.2012.08.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23153976"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23153976"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Sumedha Sudhaman, Uday B Muthane, Madhuri Behari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evidence of mutations in RIC3 acetylcholine receptor chaperone as a novel cause of autosomal-dominant Parkinson's disease with non-motor phenotypes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jmedgenet-2015-103616"}], "href": "https://doi.org/10.1136/jmedgenet-2015-103616"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27055476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27055476"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Jay P Ross, Nicolas Dupré, Yves Dauvilliers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RIC3 variants are not associated with Parkinson's disease in French-Canadians and French."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Aging (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neurobiolaging.2017.01.005"}], "href": "https://doi.org/10.1016/j.neurobiolaging.2017.01.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28153381"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28153381"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Dan He, Pengzhi Hu, Xiong Deng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic analysis of the RIC3 gene in Han Chinese patients with Parkinson's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurosci Lett (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neulet.2017.06.007"}], "href": "https://doi.org/10.1016/j.neulet.2017.06.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28606768"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28606768"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Yael Ben-David, Sara Kagan, Hagit Cohen Ben-Ami, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RIC3, the cholinergic anti-inflammatory pathway, and neuroinflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Immunopharmacol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.intimp.2020.106381"}], "href": "https://doi.org/10.1016/j.intimp.2020.106381"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32179243"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32179243"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Kajsa Brolin, Sara Bandres-Ciga, Hampton Leonard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RIC3 variants are not associated with Parkinson's disease in large European, Latin American, or East Asian cohorts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Aging (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neurobiolaging.2021.08.009"}], "href": "https://doi.org/10.1016/j.neurobiolaging.2021.08.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34538707"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34538707"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Navneesh Yadav, B K Thelma "}, {"type": "b", "children": [{"type": "t", "text": "Deletion induced splicing in RIC3 drives nicotinic acetylcholine receptor regulation with implications for endoplasmic reticulum stress in human astrocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Glia (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/glia.24333"}], "href": "https://doi.org/10.1002/glia.24333"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36602087"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36602087"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Aditi Pradhan, Hayley Mounford, Jessica Peixinho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Unraveling the molecular interactions between α7 nicotinic receptor and a RIC3 variant associated with backward speech."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-024-05149-8"}], "href": "https://doi.org/10.1007/s00018-024-05149-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38472514"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38472514"}]}]}]}
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| Synonyms | PRO1385, AYST720 |
| Proteins | RIC3_HUMAN |
| NCBI Gene ID | 79608 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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RIC3 has 4,649 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 99 datasets.
Click the + buttons to view associations for RIC3 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of RIC3 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of RIC3 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of RIC3 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of RIC3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of RIC3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of RIC3 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of RIC3 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of RIC3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of RIC3 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| Carcinogenome Chemical Perturbation Carcinogenicity Signatures | small molecule perturbations changing expression of RIC3 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of RIC3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of RIC3 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with RIC3 gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of RIC3 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of RIC3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of RIC3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of RIC3 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of RIC3 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing RIC3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing RIC3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with RIC3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with RIC3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with RIC3 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Chemical Interactions | chemicals interacting with RIC3 gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
| CTD Gene-Disease Associations | diseases associated with RIC3 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by RIC3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with RIC3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with RIC3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with RIC3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with RIC3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with RIC3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at RIC3 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of RIC3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of RIC3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing RIC3 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GAD High Level Gene-Disease Associations | diseases associated with RIC3 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of RIC3 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with RIC3 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing RIC3 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of RIC3 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of RIC3 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of RIC3 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of RIC3 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of RIC3 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of RIC3 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving RIC3 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving RIC3 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving RIC3 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing RIC3 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing RIC3 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing RIC3 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by RIC3 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GTEx eQTL 2025 | SNPs regulating expression of RIC3 gene from the GTEx eQTL 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of RIC3 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of RIC3 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of RIC3 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of RIC3 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with RIC3 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with RIC3 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with RIC3 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of RIC3 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of RIC3 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of RIC3 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of RIC3 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of RIC3 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with RIC3 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for RIC3 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of RIC3 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of RIC3 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of RIC3 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of RIC3 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with RIC3 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of RIC3 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of RIC3 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain RIC3 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of RIC3 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of RIC3 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
| MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of RIC3 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of RIC3 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for RIC3 from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of RIC3 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of RIC3 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving RIC3 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving RIC3 protein from the Wikipathways PFOCR 2024 dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at RIC3 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of RIC3 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of RIC3 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of RIC3 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of RIC3 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of RIC3 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of RIC3 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of RIC3 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of RIC3 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of RIC3 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of RIC3 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of RIC3 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with RIC3 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with RIC3 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
| WikiPathways Pathways 2024 | pathways involving RIC3 protein from the WikiPathways Pathways 2024 dataset. | |
