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These activities also extend to its participation in the resolution of ultrafine anaphase bridges and in the orchestration of chromatin loading of other repair factors, ensuring that appropriate repair processes are engaged as dictated by cell cycle stage."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in the DNA damage response, RIF1 is a master regulator of replication timing and higher‐order chromatin organization. In human cells, it establishes mid‐S replication domains by delaying the activation of replication origins–a process that involves the regulation of MCM phosphorylation via protein phosphatase 1. 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