| Name | Rab interacting lysosomal protein |
| Description | This gene encodes a lysosomal protein that interacts with RAB7, a small GTPase that controls transport to endocytic degradative compartments. Studies using mutant forms of the two proteins suggest that this protein represents a downstream effector for RAB7, and both proteins act together in the regulation of late endocytic traffic. A unique region of this protein has also been shown to be involved in the regulation of lysosomal morphology. [provided by RefSeq, Sep 2011] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRILP (Rab7‐interacting lysosomal protein) is a pivotal Rab7 effector that orchestrates the dynamics and positioning of late endosomes and lysosomes. By binding active Rab7—and, in some contexts, Rab34—RILP recruits the dynein–dynactin motor complex to promote minus‐end–directed microtubule transport. Structural studies have revealed that RILP functions as a homodimer and that specific regions (for example, a unique 62–amino acid stretch) as well as naturally occurring splice variants are critical for its ability to couple Rab7 with motor proteins, thereby regulating lysosomal morphology and positioning."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in vesicular transport, RILP coordinates endosomal maturation and fusion events through direct interactions with key tethering and sorting complexes. It engages with components of the ESCRT‐II machinery and the HOPS complex—interacting notably with VPS41—to facilitate multivesicular body biogenesis and the lysosomal degradation of signaling receptors such as EGFR."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRILP also contributes to the regulation of lipid homeostasis by modulating endolysosomal cholesterol processing. By interacting with cholesterol-sensing proteins and the V1G1 subunit of the V-ATPase, RILP influences both lysosomal acidification and ER–endolysosome contact site formation, thereby regulating cholesterol export and, when perturbed, triggering autophagy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its cytoplasmic functions, RILP has been implicated in nuclear signaling. It facilitates the nuclear translocation of transcriptional repressors such as REST/NRSF by interacting—often indirectly through complexes involving dynactin p150(Glued) and huntingtin—with these regulators. This role in nuclear targeting underscores a broader impact of RILP on gene expression and neuronal function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nPathogens further illustrate the functional versatility of RILP by subverting its normal role. During infection by RNA viruses such as hepatitis C and Sendai virus, host caspases (notably caspase-1) mediate RILP cleavage. The resulting truncated form of RILP shifts the balance of vesicular transport from a dynein-dependent to a kinesin-dependent mechanism, thereby favoring viral egress."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFinally, RILP serves as a tumor suppressor in several cancer types, including breast, lung, and prostate cancers. Its interaction with RalGDS modulates the activation of the downstream effector RalA, leading to inhibition of cancer cell proliferation, migration, and invasion. This tumor-suppressive function positions RILP as a potential target for therapeutic intervention."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "17", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tuanlao Wang, Ka Khuen Wong, Wanjin Hong "}, {"type": "b", "children": [{"type": "t", "text": "A unique region of RILP distinguishes it from its related proteins in its regulation of lysosomal morphology and interaction with Rab7 and Rab34."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e03-06-0413"}], "href": "https://doi.org/10.1091/mbc.e03-06-0413"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14668488"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14668488"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mousheng Wu, Tuanlao Wang, Eva Loh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis for recruitment of RILP by small GTPase Rab7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.emboj.7600643"}], "href": "https://doi.org/10.1038/sj.emboj.7600643"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15933719"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15933719"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Anna Maria Rosaria Colucci, Maria Carmela Campana, Marianna Bellopede, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Rab-interacting lysosomal protein, a Rab7 and Rab34 effector, is capable of self-interaction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2005.06.067"}], "href": "https://doi.org/10.1016/j.bbrc.2005.06.067"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15996637"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15996637"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Marije Marsman, Ingrid Jordens, Nuno Rocha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A splice variant of RILP induces lysosomal clustering independent of dynein recruitment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2006.03.178"}], "href": "https://doi.org/10.1016/j.bbrc.2006.03.178"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16631113"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16631113"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Nuno Rocha, Coenraad Kuijl, Rik van der Kant, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7-RILP-p150 Glued and late endosome positioning."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200811005"}], "href": "https://doi.org/10.1083/jcb.200811005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19564404"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19564404"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Rik van der Kant, Alexander Fish, Lennert Janssen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Late endosomal transport and tethering are coupled processes controlled by RILP and the cholesterol sensor ORP1L."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.129270"}], "href": "https://doi.org/10.1242/jcs.129270"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23729732"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23729732"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Cinzia Progida, Maria Rita Spinosa, Azzurra De Luca, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RILP interacts with the VPS22 component of the ESCRT-II complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2006.07.007"}], "href": "https://doi.org/10.1016/j.bbrc.2006.07.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16857164"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16857164"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Cinzia Progida, Lene Malerød, Susanne Stuffers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RILP is required for the proper morphology and function of late endosomes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.017301"}], "href": "https://doi.org/10.1242/jcs.017301"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17959629"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17959629"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Xiaosi Lin, Ting Yang, Shicong Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RILP interacts with HOPS complex via VPS41 subunit to regulate endocytic trafficking."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep07282"}], "href": "https://doi.org/10.1038/srep07282"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25445562"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25445562"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Xinli Ma, Kai Liu, Jian Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A non-canonical GTPase interaction enables ORP1L-Rab7-RILP complex formation and late endosome positioning."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA118.001854"}], "href": "https://doi.org/10.1074/jbc.RA118.001854"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30012887"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30012887"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Maria De Luca, Laura Cogli, Cinzia Progida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RILP regulates vacuolar ATPase through interaction with the V1G1 subunit."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.142604"}], "href": "https://doi.org/10.1242/jcs.142604"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24762812"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24762812"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Yang Han, Xiaoqing Liu, Liju Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RILP Induces Cholesterol Accumulation in Lysosomes by Inhibiting Endoplasmic Reticulum-Endolysosome Interactions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells13161313"}], "href": "https://doi.org/10.3390/cells13161313"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39195203"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39195203"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Masahito Shimojo, Louis B Hersh "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of the REST/NRSF-interacting LIM domain protein (RILP): localization and interaction with REST/NRSF."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurochem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1471-4159.2005.03608.x"}], "href": "https://doi.org/10.1111/j.1471-4159.2005.03608.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16417580"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16417580"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Masahito Shimojo "}, {"type": "b", "children": [{"type": "t", "text": "Huntingtin regulates RE1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) nuclear trafficking indirectly through a complex with REST/NRSF-interacting LIM domain protein (RILP) and dynactin p150 Glued."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M804183200"}], "href": "https://doi.org/10.1074/jbc.M804183200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18922795"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18922795"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Ann L Wozniak, Abby Long, Kellyann N Jones-Jamtgaard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hepatitis C virus promotes virion secretion through cleavage of the Rab7 adaptor protein RILP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1607277113"}], "href": "https://doi.org/10.1073/pnas.1607277113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27791088"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27791088"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Abby Adams, Steven A Weinman, Ann L Wozniak "}, {"type": "b", "children": [{"type": "t", "text": "Caspase-1 regulates cellular trafficking via cleavage of the Rab7 adaptor protein RILP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.08.013"}], "href": "https://doi.org/10.1016/j.bbrc.2018.08.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30100068"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30100068"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Z Wang, Y Zhou, X Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RILP suppresses invasion of breast cancer cells by modulating the activity of RalA through interaction with RalGDS."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2015.266"}], "href": "https://doi.org/10.1038/cddis.2015.266"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26469971"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26469971"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Jianbo Lin, Yi Zhuo, Yinhe Yin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Methylation of RILP in lung cancer promotes tumor cell proliferation and invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-020-03950-0"}], "href": "https://doi.org/10.1007/s11010-020-03950-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33128214"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33128214"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Zhen Wang, Yunhe Zhou, Dongsong Nie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RILP inhibits proliferation, migration, and invasion of PC3 prostate cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Histochem (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.acthis.2022.151938"}], "href": "https://doi.org/10.1016/j.acthis.2022.151938"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35981451"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35981451"}]}]}]}
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| Synonyms | PP10141 |
| Proteins | RILP_HUMAN |
| NCBI Gene ID | 83547 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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RILP has 4,047 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 84 datasets.
Click the + buttons to view associations for RILP from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of RILP gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of RILP gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of RILP gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of RILP gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of RILP gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of RILP gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of RILP gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of RILP gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of RILP gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| CCLE Cell Line Proteomics | Cell lines associated with RILP protein from the CCLE Cell Line Proteomics dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with RILP gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of RILP gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of RILP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of RILP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing RILP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with RILP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of RILP gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with RILP gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Chemical Interactions | chemicals interacting with RILP gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
| CTD Gene-Disease Associations | diseases associated with RILP gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by RILP gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with RILP gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with RILP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with RILP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with RILP gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at RILP gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of RILP gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of RILP gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing RILP from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GAD High Level Gene-Disease Associations | diseases associated with RILP gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with RILP gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing RILP from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of RILP gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of RILP gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of RILP gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of RILP gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of RILP gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of RILP gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving RILP gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving RILP gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing RILP protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing RILP protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by RILP gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by RILP gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of RILP gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of RILP gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of RILP gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of RILP gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of RILP gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of RILP gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of RILP gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of RILP protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of RILP gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with RILP gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| IMPC Knockout Mouse Phenotypes | phenotypes of mice caused by RILP gene knockout from the IMPC Knockout Mouse Phenotypes dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for RILP protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of RILP gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Kinase Library Serine Threonine Kinome Atlas | kinases that phosphorylate RILP protein from the Kinase Library Serine Threonine Atlas dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of RILP gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of RILP gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with RILP gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of RILP gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LOCATE Curated Protein Localization Annotations | cellular components containing RILP protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain RILP protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by RILP gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of RILP gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| NURSA Protein Complexes | protein complexs containing RILP protein recovered by IP-MS from the NURSA Protein Complexes dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for RILP from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of RILP gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of RILP gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving RILP protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving RILP protein from the Wikipathways PFOCR 2024 dataset. | |
| Reactome Pathways 2014 | pathways involving RILP protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving RILP protein from the Reactome Pathways 2024 dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of RILP gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of RILP gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at RILP gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of RILP gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of RILP gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of RILP gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of RILP gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of RILP protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of RILP protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with RILP protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
