RING1 Gene

HGNC Family	Zinc fingers
Name	ring finger protein 1
Description	This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRING1 proteins are core components of the Polycomb repressive complex 1 (PRC1) whose primary function is to catalyze the monoubiquitination of histone H2A, thereby contributing to transcriptional repression and epigenetic gene regulation. In this context, RING1 not only facilitates the maintenance of repressive chromatin states during the cell cycle (for instance, by “bookmarking” active promoters during mitosis) but also interfaces with developmental regulators. Disturbances in RING1 enzymatic activity—such as mutations that impair histone H2A ubiquitination despite retained ubiquitin chain formation—lead to defects in DNA damage repair and cell cycle progression in neural progenitor cells, while interactions with proteins like MESP1 are critical for cardiogenic gene activation and normal heart development."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn cancer contexts, dysregulation of RING1 is associated with both protumorigenic and tumor‐suppressive outcomes that appear to be highly tissue and context dependent. For instance, overexpression of RING1 (or its related family members) has been observed in hematological malignancies and hepatocellular carcinoma, where it can act as an E3 ubiquitin ligase targeting crucial regulatory proteins such as p53 for degradation, thus promoting cell survival and proliferation. Conversely, in certain settings such as breast cancer, restoration of RING1 function inhibits tumor cell proliferation by inducing the degradation of transcriptional activators like HSF1, which in turn downregulates oncogenic targets. Additional studies have implicated RING1 in the regulation of cell cycle progression and autophagy (notably in endometrial cancer), as well as in modulating cell migration via interactions with membrane proteins such as CD147 in melanoma."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its central roles in chromatin modification and cancer, genetic and association studies further suggest that alterations near the RING1 locus may contribute to autoimmune predispositions—for example, single nucleotide polymorphisms close to RING1 have been linked to type 1 diabetes—and that RING1 is subject to regulation by additional factors that fine‐tune its activity in response to cellular stress. These findings underscore the multifaceted nature of RING1 function, which ranges from the orchestration of developmental gene expression programs to the modulation of cellular responses in diverse diseases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Miguel Vidal "}, {"type": "b", "children": [{"type": "t", "text": "Role of polycomb proteins Ring1A and Ring1B in the epigenetic regulation of gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Dev Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1387/ijdb.082690mv"}], "href": "https://doi.org/10.1387/ijdb.082690mv"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19412891"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19412891"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Prim de Bie, Daphna Zaaroor-Regev, Aaron Ciechanover "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of the Polycomb protein RING1B ubiquitination by USP7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2010.08.082"}], "href": "https://doi.org/10.1016/j.bbrc.2010.08.082"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20800574"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20800574"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Feng Xu, Xiao Li, Lingyun Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of the EZH2, RING1 and BMI1 genes is common in myelodysplastic syndromes: relation to adverse epigenetic alteration and poor prognostic scoring."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Hematol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00277-010-1128-5"}], "href": "https://doi.org/10.1007/s00277-010-1128-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21125401"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21125401"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Mansi Arora, Colin Z Packard, Tapahsama Banerjee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RING1A and BMI1 bookmark active genes via ubiquitination of chromatin-associated proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkv1223"}], "href": "https://doi.org/10.1093/nar/gkv1223"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26578590"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26578590"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Sarah B Pierce, Mikaela D Stewart, Suleyman Gulsuner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "De novo mutation in "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "RING1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " with epigenetic effects on neurodevelopment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1721290115"}], "href": "https://doi.org/10.1073/pnas.1721290115"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29386386"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29386386"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Qianqian Liang, Siqing Wang, Xinyan Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Essential role of MESP1-RING1A complex in cardiac differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Cell (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.devcel.2022.10.009"}], "href": "https://doi.org/10.1016/j.devcel.2022.10.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36413948"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36413948"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "C W Ryan, S L Regan, E F Mills, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RING1 missense variants reveal sensitivity of DNA damage repair to H2A monoubiquitination dosage during neurogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-024-52292-8"}], "href": "https://doi.org/10.1038/s41467-024-52292-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39256363"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39256363"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yiqun Zhou, Chunhua Wan, Yifei Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polycomb group oncogene RING1 is over-expressed in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Oncol Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12253-013-9727-9"}], "href": "https://doi.org/10.1007/s12253-013-9727-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24414991"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24414991"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Bin Hu, Shangze Li, Xiaodong Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HSCARG, a novel regulator of H2A ubiquitination by downregulating PRC1 ubiquitin E3 ligase activity, is essential for cell proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gku230"}], "href": "https://doi.org/10.1093/nar/gku230"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24711370"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24711370"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yicheng Xiong, Baoying Hu, Lixian Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulated expression of polycomb protein Ring1 contributes to poor prognosis and accelerated proliferation in human hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-015-3721-7"}], "href": "https://doi.org/10.1007/s13277-015-3721-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26141041"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26141041"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Junchen Chen, Cong Peng, Li Lei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear envelope-distributed CD147 interacts with and inhibits the transcriptional function of RING1 and promotes melanoma cell motility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0183689"}], "href": "https://doi.org/10.1371/journal.pone.0183689"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28832687"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28832687"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Jiajia Shen, Pengyu Li, Xuejing Shao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-17-1805"}], "href": "https://doi.org/10.1158/0008-5472.CAN-17-1805"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29187402"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29187402"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Di Liu, Yize Guo, Qin Du, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RING induces cell cycle arrest and apoptosis in human breast cancer cells by regulating the HSF1/MT2A axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2023.113795"}], "href": "https://doi.org/10.1016/j.yexcr.2023.113795"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37797799"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37797799"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Aleksandra Szustka, Karolina Kozal, Anna Krześlak "}, {"type": "b", "children": [{"type": "t", "text": "RING1 Inhibition Has a Cell-Specific Antitumoral Role by Promoting Autophagy in Endometrial Cancer Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.33594/000000679"}], "href": "https://doi.org/10.33594/000000679"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38219048"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38219048"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "M C Eike, T Becker, K Humphreys, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Conditional analyses on the T1DGC MHC dataset: novel associations with type 1 diabetes around HLA-G and confirmation of HLA-B."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Immun (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/gene.2008.74"}], "href": "https://doi.org/10.1038/gene.2008.74"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18830248"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18830248"}]}]}]}
Synonyms	RING1A, RNF1
Proteins	RING1_HUMAN
NCBI Gene ID	6015
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RING1 has 6,718 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 122 datasets.

Click the + buttons to view associations for RING1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RING1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by RING1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of RING1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of RING1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of RING1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RING1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Biocarta Pathways	pathways involving RING1 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RING1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RING1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RING1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of RING1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RING1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of RING1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with RING1 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RING1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RING1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RING1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing RING1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RING1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RING1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing RING1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RING1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RING1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing RING1 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RING1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with RING1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with RING1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of RING1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by RING1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with RING1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with RING1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RING1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RING1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RING1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RING1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RING1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RING1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of RING1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing RING1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with RING1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with RING1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.