{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRIT1 is emerging as a key regulator in developmental disorders, most notably in Noonan syndrome and related RASopathies. Germline gain‐of‐function mutations in RIT1 have been shown to dysregulate RAS–MAPK signaling, contributing to the characteristic facial dysmorphism, congenital heart defects (including hypertrophic cardiomyopathy and, in rare cases, coronary anomalies), and other systemic manifestations seen in these patients. Studies in cellular and zebrafish models demonstrate that mutant RIT1 enhances downstream transactivation (e.g., of ELK1) and perturbs normal heart and craniofacial development, thereby recapitulating the Noonan phenotype."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in developmental disorders, RIT1 functions as an oncogenic driver in a subset of cancers. Somatic mutations and amplifications of RIT1 have been identified in lung adenocarcinoma, as well as aberrant overexpression in endometrial cancer, hepatocellular carcinoma, esophageal squamous cell carcinoma, glioblastoma, and glioma. In these contexts, altered RIT1 activity promotes cellular transformation and malignant progression through enhanced PI3K/AKT, MEK–ERK, and other pathway signaling cascades, thereby conferring unique vulnerabilities that might be exploited therapeutically."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "25"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in development and oncogenesis, RIT1 is also critically involved in neuronal signaling and cellular stress responses. In neuronal models, active RIT1 promotes neurite initiation, elongation, and branching by engaging both MEK‐dependent and independent pathways, including a distinctive p38–MSK1/2 cascade that modulates CREB-dependent transcription and cell survival. This highlights an important function for RIT1 in neural differentiation and in orchestrating cellular protective responses to stress."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "26", "end_ref": "31"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yoko Aoki, Tetsuya Niihori, Toshihiro Banjo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gain-of-function mutations in RIT1 cause Noonan syndrome, a RAS/MAPK pathway syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2013.05.021"}], "href": "https://doi.org/10.1016/j.ajhg.2013.05.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23791108"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23791108"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Débora R Bertola, Guilherme L Yamamoto, Tatiana F Almeida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Further evidence of the importance of RIT1 in Noonan syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.36722"}], "href": "https://doi.org/10.1002/ajmg.a.36722"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25124994"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25124994"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "M Koenighofer, C Y Hung, J L McCauley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in RIT1 cause Noonan syndrome - additional functional evidence and expanding the clinical phenotype."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cge.12608"}], "href": "https://doi.org/10.1111/cge.12608"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25959749"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25959749"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Michaela Nemcikova, Sarka Vejvalkova, Filip Fencl, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel heterozygous RIT1 mutation in a patient with Noonan syndrome, leukopenia, and transient myeloproliferation-a review of the literature."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Pediatr (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00431-015-2658-6"}], "href": "https://doi.org/10.1007/s00431-015-2658-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26518681"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26518681"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Masako Yaoita, Tetsuya Niihori, Seiji Mizuno, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Spectrum of mutations and genotype-phenotype analysis in Noonan syndrome patients with RIT1 mutations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00439-015-1627-5"}], "href": "https://doi.org/10.1007/s00439-015-1627-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26714497"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26714497"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Hélène Cavé, Aurélie Caye, Nehla Ghedira, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in RIT1 cause Noonan syndrome with possible juvenile myelomonocytic leukemia but are not involved in acute lymphoblastic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ejhg.2015.273"}], "href": "https://doi.org/10.1038/ejhg.2015.273"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26757980"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26757980"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Karim Kouz, Christina Lissewski, Stephanie Spranger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genotype and phenotype in patients with Noonan syndrome and a RIT1 mutation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Med (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/gim.2016.32"}], "href": "https://doi.org/10.1038/gim.2016.32"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27101134"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27101134"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Doris Milosavljević, Eline Overwater, Saskia Tamminga, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Two cases of RIT1 associated Noonan syndrome: Further delineation of the clinical phenotype and review of the literature."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.37657"}], "href": "https://doi.org/10.1002/ajmg.a.37657"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27109146"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27109146"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Francis Ramond, Sébastien Duband, Pierre Croisille, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expanding the cardiac spectrum of Noonan syndrome with RIT1 variant: Left main coronary artery atresia causing sudden death."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Med Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejmg.2017.03.009"}], "href": "https://doi.org/10.1016/j.ejmg.2017.03.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28347726"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28347726"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Gordon K C Leung, H M Luk, Vincent H M Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrating Functional Analysis in the Next-Generation Sequencing Diagnostic Pipeline of RASopathies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-20894-0"}], "href": "https://doi.org/10.1038/s41598-018-20894-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29402968"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29402968"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Pau Castel, Alice Cheng, Antonio Cuevas-Navarro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RIT1 oncoproteins escape LZTR1-mediated proteolysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.aav1444"}], "href": "https://doi.org/10.1126/science.aav1444"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30872527"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30872527"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Richard Van, Antonio Cuevas-Navarro, Pau Castel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The molecular functions of RIT1 and its contribution to human disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BCJ20200442"}], "href": "https://doi.org/10.1042/BCJ20200442"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32766847"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32766847"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yasuhiro Ichikawa, Hiroyuki Kuroda, Takeshi Ikegawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cardiac features of Noonan syndrome in Japanese patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cardiol Young (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1017/S104795112200124X"}], "href": "https://doi.org/10.1017/S104795112200124X"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35475426"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35475426"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Jin-tian Li, Wei Liu, Zhi-he Kuang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Mutation and amplification of RIT1 gene in hepatocellular carcinoma]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Yi Xue Yi Chuan Xue Za Zhi (2004)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14767908"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14767908"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "A H Berger, M Imielinski, F Duke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oncogenic RIT1 mutations in lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2013.581"}], "href": "https://doi.org/10.1038/onc.2013.581"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24469055"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24469055"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Fengjuan Xu, Su'an Sun, Shilan Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elevated expression of RIT1 correlates with poor prognosis in endometrial cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Clin Exp Pathol (2015)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26617739"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26617739"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Zhenhao Fang, Christopher B Marshall, Jiani C Yin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Biochemical Classification of Disease-associated Mutants of RAS-like Protein Expressed in Many Tissues (RIT1)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M116.714196"}], "href": "https://doi.org/10.1074/jbc.M116.714196"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27226556"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27226556"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Uta Meyer Zum Büschenfelde, Laura Isabel Brandenstein, Leonie von Elsner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RIT1 controls actin dynamics via complex formation with RAC1/CDC42 and PAK1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1007370"}], "href": "https://doi.org/10.1371/journal.pgen.1007370"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29734338"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29734338"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Yan-Fen Feng, Yi-Yan Lei, Jia-Bin Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RIT1 suppresses esophageal squamous cell carcinoma growth and metastasis and predicts good prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-018-0979-x"}], "href": "https://doi.org/10.1038/s41419-018-0979-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30348939"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30348939"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Athar Khalil, Georges Nemer "}, {"type": "b", "children": [{"type": "t", "text": "The potential oncogenic role of the RAS-like GTP-binding gene RIT1 in glioblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biomark (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/CBM-191264"}], "href": "https://doi.org/10.3233/CBM-191264"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32831193"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32831193"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Dilek Uludağ Alkaya, Christina Lissewski, Gözde Yeşil, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expanding the clinical phenotype of RASopathies in 38 Turkish patients, including the rare LZTR1, RAF1, RIT1 variants, and large deletion in NF1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.62410"}], "href": "https://doi.org/10.1002/ajmg.a.62410"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34184824"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34184824"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Athea Vichas, Amanda K Riley, Naomi T Nkinsi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-021-24841-y"}], "href": "https://doi.org/10.1038/s41467-021-24841-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34373451"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34373451"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "April Lo, Kristin Holmes, Shriya Kamlapurkar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multiomic characterization of oncogenic signaling mediated by wild-type and mutant RIT1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.abc4520"}], "href": "https://doi.org/10.1126/scisignal.abc4520"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34846918"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34846918"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Minggang Che, Qing Lan "}, {"type": "b", "children": [{"type": "t", "text": "RIT1 Promotes Glioma Proliferation and Invasion via the AKT/ERK/NF-ĸB Signaling Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Neurosci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12031-022-01978-z"}], "href": "https://doi.org/10.1007/s12031-022-01978-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35290620"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35290620"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Yang Su, Hechun Lin, Junming Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RIT1 regulates mitosis and promotes proliferation by interacting with SMC3 and PDS5 in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-023-02892-x"}], "href": "https://doi.org/10.1186/s13046-023-02892-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38017479"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38017479"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "DiAnna L Hynds, Mike L Spencer, Douglas A Andres, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rit promotes MEK-independent neurite branching in human neuroblastoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.00401"}], "href": "https://doi.org/10.1242/jcs.00401"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12668729"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12668729"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Geng-Xian Shi, Douglas A Andres "}, {"type": "b", "children": [{"type": "t", "text": "Rit contributes to nerve growth factor-induced neuronal differentiation via activation of B-Raf-extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.25.2.830-846.2005"}], "href": "https://doi.org/10.1128/MCB.25.2.830-846.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15632082"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15632082"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Geng-Xian Shi, Ling Jin, Douglas A Andres "}, {"type": "b", "children": [{"type": "t", "text": "A rit GTPase-p38 mitogen-activated protein kinase survival pathway confers resistance to cellular stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01380-10"}], "href": "https://doi.org/10.1128/MCB.01380-10"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21444726"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21444726"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Geng-Xian Shi, Weikang Cai, Douglas A Andres "}, {"type": "b", "children": [{"type": "t", "text": "Rit-mediated stress resistance involves a p38-mitogen- and stress-activated protein kinase 1 (MSK1)-dependent cAMP response element-binding protein (CREB) activation cascade."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.384248"}], "href": "https://doi.org/10.1074/jbc.M112.384248"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23038261"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23038261"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Weikang Cai, Jennifer L Rudolph, Tomoko Sengoku, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rit GTPase regulates a p38 MAPK-dependent neuronal survival pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurosci Lett (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neulet.2012.10.036"}], "href": "https://doi.org/10.1016/j.neulet.2012.10.036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23123784"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23123784"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Geng-Xian Shi, Weikang Cai, Douglas A Andres "}, {"type": "b", "children": [{"type": "t", "text": "Rit subfamily small GTPases: regulators in neuronal differentiation and survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2013.06.002"}], "href": "https://doi.org/10.1016/j.cellsig.2013.06.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23770287"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23770287"}]}]}]}