RLIM Gene

HGNC Family	Zinc fingers
Name	ring finger protein, LIM domain interacting
Description	The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be an E3 ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2009]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRLIM (also known as RNF12) is an X‐linked E3 ubiquitin ligase with critical roles during early development and epigenetic regulation. It has been shown to promote X chromosome inactivation (XCI) by acting as a dose‐dependent activator of Xist transcription in mouse embryonic stem cells, thereby contributing to proper XCI counting."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In non‐mammalian vertebrates, studies in Xenopus have revealed that RLIM (XRnf12) modulates the function of LIM homeodomain transcription factors by targeting the coactivator Ldb1 for proteasomal degradation, ensuring the optimal stoichiometry of transcriptional complexes required for organizer gene expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Furthermore, the protein’s activity is tightly controlled by regulatory mechanisms, including p53‐dependent transcriptional repression and phosphorylation‐mediated nucleocytoplasmic shuttling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its developmental functions, RLIM orchestrates the ubiquitin‐dependent turnover of a diverse array of substrates, thereby modulating multiple cellular processes. It targets the telomeric protein TRF1 for degradation to regulate telomere length"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", and it enhances TGF‑β signaling—thereby promoting cell migration—by interacting with key pathway regulators."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " RLIM also controls the abundance of oncoproteins such as Stathmin"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "and modulates p53 stability indirectly through its ubiquitin‐directed degradation of MDM2."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Moreover, by ubiquitinating BRF1, a key transcription factor component of RNA polymerase III machinery, RLIM exerts negative regulation on Pol III–dependent transcription, while its activity can be further modulated by viral proteins such as KSHV LANA that influence RLIM autoubiquitination and substrate turnover."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMutations and aberrant expression of RLIM have now been implicated in a spectrum of human disorders and malignancies. Missense variants and gene copy alterations in RLIM are linked to X‐linked intellectual disability (XLID) syndromes, ranging from milder neurocognitive phenotypes to severe forms such as Tonne‐Kalscheuer syndrome."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "15"}]}, {"type": "t", "text": " Structural investigations of RNF12’s RING domain have elucidated its interactions with ubiquitin‐conjugating enzymes, providing insight into the molecular basis for disease‐causing mutations."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": " RLIM is also vital for gametogenesis by stabilizing deubiquitylating enzymes like USP26"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": ", and its dysregulation contributes to oncogenic signaling in breast and liver cancers as well as in medulloblastoma through perturbation of key pathways such as TGF‑β and Sonic hedgehog."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "18", "end_ref": "20"}]}, {"type": "t", "text": " Collectively, these diverse roles underscore RLIM as an essential regulator whose ubiquitin ligase activity is central to maintaining the balance of protein turnover and signal transduction in both normal development and disease.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Iris Jonkers, Tahsin Stefan Barakat, Eskeatnaf Mulugeta Achame, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNF12 is an X-Encoded dose-dependent activator of X chromosome inactivation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2009.10.034"}], "href": "https://doi.org/10.1016/j.cell.2009.10.034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19945382"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19945382"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Feng Wang, Poonam Mehta, Ingolf Bach "}, {"type": "b", "children": [{"type": "t", "text": "How does the Xist activator Rlim/Rnf12 regulate Xist expression?"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Soc Trans (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BST20230573"}], "href": "https://doi.org/10.1042/BST20230573"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38747697"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38747697"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ichiro Hiratani, Naoko Yamamoto, Toshiaki Mochizuki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Selective degradation of excess Ldb1 by Rnf12/RLIM confers proper Ldb1 expression levels and Xlim-1/Ldb1 stoichiometry in Xenopus organizer functions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.00621"}], "href": "https://doi.org/10.1242/dev.00621"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12874135"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12874135"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiangtao Kong, Bo Peng, Yang Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p53 Represses transcription of RING finger LIM domain-binding protein RLIM through Sp1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0062832"}], "href": "https://doi.org/10.1371/journal.pone.0062832"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23650532"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23650532"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Baowei Jiao, Naoko Taniguchi-Ishigaki, Cenap Güngör, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional activity of RLIM/Rnf12 is regulated by phosphorylation-dependent nucleocytoplasmic shuttling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E13-05-0239"}], "href": "https://doi.org/10.1091/mbc.E13-05-0239"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23904271"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23904271"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yoon Ra Her, In Kwon Chung "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitin Ligase RLIM Modulates Telomere Length Homeostasis through a Proteolysis of TRF1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M806702200"}], "href": "https://doi.org/10.1074/jbc.M806702200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19164295"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19164295"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yongsheng Huang, Yang Yang, Rui Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RLIM interacts with Smurf2 and promotes TGF-β induced U2OS cell migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2011.09.053"}], "href": "https://doi.org/10.1016/j.bbrc.2011.09.053"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21945933"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21945933"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xi Chen, Jianjun Shen, Xingyu Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rlim, an E3 ubiquitin ligase, influences the stability of Stathmin protein in human osteosarcoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2014.03.018"}], "href": "https://doi.org/10.1016/j.cellsig.2014.03.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24686088"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24686088"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Kun Gao, Chenji Wang, Xiaofeng Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNF12 promotes p53-dependent cell growth suppression and apoptosis by targeting MDM2 for destruction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2016.02.013"}], "href": "https://doi.org/10.1016/j.canlet.2016.02.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26926424"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26926424"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Fang Wang, Kailiang Zhao, Sixiang Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNF12 catalyzes BRF1 ubiquitination and regulates RNA polymerase III-dependent transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA118.004524"}], "href": "https://doi.org/10.1074/jbc.RA118.004524"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30413534"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30413534"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Hagar Tadmor, Melanie Greenway, Anuj Ahuja, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Kaposi's Sarcoma-Associated Herpesvirus LANA Modulates the Stability of the E3 Ubiquitin Ligase RLIM."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.01578-19"}], "href": "https://doi.org/10.1128/JVI.01578-19"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31801865"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31801865"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Elin Tønne, Rita Holdhus, Christine Stansberg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Syndromic X-linked intellectual disability segregating with a missense variant in RLIM."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ejhg.2015.30"}], "href": "https://doi.org/10.1038/ejhg.2015.30"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25735484"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25735484"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Francisco Bustos, Anna Segarra-Fas, Viduth K Chaugule, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNF12 X-Linked Intellectual Disability Mutations Disrupt E3 Ligase Activity and Neural Differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2018.04.022"}], "href": "https://doi.org/10.1016/j.celrep.2018.04.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29742418"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29742418"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Francisco Bustos, Carmen Espejo-Serrano, Anna Segarra-Fas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel RLIM/RNF12 variant disrupts protein stability and function to cause severe Tonne-Kalscheuer syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-021-88911-3"}], "href": "https://doi.org/10.1038/s41598-021-88911-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33953269"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33953269"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Yuwei Li, Chencheng Yang, Huishan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sequential stabilization of RNF220 by RLIM and ZC4H2 during cerebellum development and Shh-group medulloblastoma progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Cell Biol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jmcb/mjab082"}], "href": "https://doi.org/10.1093/jmcb/mjab082"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35040952"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35040952"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "A J Middleton, J Zhu, C L Day "}, {"type": "b", "children": [{"type": "t", "text": "The RING Domain of RING Finger 12 Efficiently Builds Degradative Ubiquitin Chains."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2020.05.001"}], "href": "https://doi.org/10.1016/j.jmb.2020.05.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32416094"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32416094"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Elizabeth E Palmer, Renee Carroll, Marie Shaw, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RLIM Is a Candidate Dosage-Sensitive Gene for Individuals with Varying Duplications of Xq13, Intellectual Disability, and Distinct Facial Features."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2020.10.005"}], "href": "https://doi.org/10.1016/j.ajhg.2020.10.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33159883"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33159883"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Yongsheng Huang, Sijia Liu, Mengjie Shan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNF12 is regulated by AKT phosphorylation and promotes TGF-β driven breast cancer metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-04493-y"}], "href": "https://doi.org/10.1038/s41419-021-04493-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35013159"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35013159"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Anna Segarra-Fas, Carmen Espejo-Serrano, Francisco Bustos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An RNF12-USP26 amplification loop drives germ cell specification and is disrupted by disease-associated mutations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.abm5995"}], "href": "https://doi.org/10.1126/scisignal.abm5995"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35857630"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35857630"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Chengpeng Yu, Dean Rao, Tiantian Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ring finger protein 12 activates AKT signalling to promote the progression of liver cancer by interacting with EGFR."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.17757"}], "href": "https://doi.org/10.1111/jcmm.17757"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37132043"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37132043"}]}]}]}
Synonyms	NY-REN-43, TOKAS, RNF12, MRX61
Proteins	RNF12_HUMAN
NCBI Gene ID	51132
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RLIM has 5,758 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 106 datasets.

Click the + buttons to view associations for RLIM from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RLIM Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by RLIM gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RLIM gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of RLIM gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of RLIM gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of RLIM gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RLIM gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RLIM gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RLIM gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of RLIM gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RLIM gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of RLIM gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with RLIM protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RLIM gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RLIM gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RLIM gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with RLIM gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RLIM protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing RLIM protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RLIM protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RLIM protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RLIM gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RLIM gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with RLIM gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with RLIM gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of RLIM protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by RLIM gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RLIM gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RLIM gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RLIM gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RLIM gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RLIM gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RLIM gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of RLIM gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing RLIM from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with RLIM gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing RLIM from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of RLIM gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of RLIM gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of RLIM gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RLIM gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.