RNF11 Gene

HGNC Family	Zinc fingers
Name	ring finger protein 11
Description	The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN). [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRNF11 is an evolutionarily conserved, small RING‐H2 E3 ubiquitin ligase that is frequently overexpressed in several human tumors—including invasive breast, prostate, colon, and hepatocellular carcinomas—and appears to play dual roles in modulating diverse signaling pathways. Its defining structural features, such as the RING domain and PY motif, mediate interactions with key regulators (e.g., Smurf2, A20, TAX1BP1, and 14–3–3 proteins) that influence transforming growth factor‐β (TGF–β) and epidermal growth factor receptor (EGFR) signaling. In various cellular contexts, RNF11 can restore TGF–β responsiveness, fine‐tune signal transduction, and even promote cell migration, thus contributing to tumor progression and metastasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAt the subcellular level, RNF11 is predominantly a membrane‐associated protein localized to early endosomes and recycling compartments—its proper targeting depending on lipid modifications such as N‐myristoylation and S‐palmitoylation. In these locales, RNF11 plays a pivotal role in regulating vesicle trafficking and receptor fate. By selectively interacting with adaptor proteins and other E3 ligases (for example, Itch and members of the GGA family), it modulates the ubiquitination status of cargo proteins, thereby influencing endocytosis, sorting, and lysosomal degradation of receptors such as EGFR. In addition, through associations with COPII components and the ESCRT machinery via partners like SARA, RNF11 links the processes of receptor internalization and recycling to signal termination."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn neuronal and immune contexts, RNF11 functions as a critical negative regulator of inflammatory signaling. As an integral component of the A20 ubiquitin–editing complex, it attenuates pathways such as NF–κB, Jun N–terminal kinase, and antiviral responses through modulating the ubiquitination of key intermediates. Decreased RNF11 expression in neurons and microglia has been linked to prolonged NF–κB activation—a phenomenon observed in neurodegenerative disorders like Parkinson’s disease where RNF11 is sequestered in Lewy bodies. Moreover, RNF11’s modulation of antiviral kinases further underscores its role in maintaining the homeostasis of inflammatory and innate immune responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nEmerging studies further highlight the nuanced regulatory mechanisms of RNF11. Detailed dissection of its RING domain has revealed molecular determinants that govern selective E2 enzyme interactions and, consequently, its ubiquitin ligase activity. At the post–transcriptional level, microRNAs (such as miR–425–5p and miR–19b–3p) have been identified that modulate RNF11 expression, thereby impacting processes as diverse as glucose metabolism in hepatocellular carcinoma and skeletal muscle, while RNF11’s influence on Akt signaling has implications for osteogenesis in bone marrow mesenchymal stem cells. Collectively, these findings position RNF11 as a multifaceted adaptor and regulator whose dysregulation may contribute to cancer progression, metabolic dysfunction, neuroinflammation, and tissue remodeling—making it a promising candidate for targeted therapeutic intervention."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "17", "end_ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "V Subramaniam, H Li, M Wong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Cancer (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.bjc.6601301"}], "href": "https://doi.org/10.1038/sj.bjc.6601301"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14562029"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14562029"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Michael K Connor, Peter B Azmi, Venkateswaran Subramaniam, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular characterization of ring finger protein 11."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-04-0166"}], "href": "https://doi.org/10.1158/1541-7786.MCR-04-0166"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16123141"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16123141"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Angelika Burger, Yutaka Amemiya, Richard Kitching, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel RING E3 ubiquitin ligases in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasia (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1593/neo.06469"}], "href": "https://doi.org/10.1593/neo.06469"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16925951"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16925951"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Noula Shembade, Kislay Parvatiyar, Nicole S Harhaj, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emboj.2008.285"}], "href": "https://doi.org/10.1038/emboj.2008.285"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19131965"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19131965"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ryan J Malonis, Wenxiang Fu, Mark J Jelcic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNF11 sequestration of the E3 ligase SMURF2 on membranes antagonizes SMAD7 down-regulation of transforming growth factor β signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M117.783662"}], "href": "https://doi.org/10.1074/jbc.M117.783662"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28292929"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28292929"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Rhesa Budhidarmo, Jingyi Zhu, Adam J Middleton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The RING domain of RING Finger 11 (RNF11) protein binds Ubc13 and inhibits formation of polyubiquitin chains."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1873-3468.13029"}], "href": "https://doi.org/10.1002/1873-3468.13029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29537486"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29537486"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Anna Mattioni, Karsten Boldt, Giulio Auciello, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ring Finger Protein 11 acts on ligand-activated EGFR via the direct interaction with the UIM region of ANKRD13 protein family."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/febs.15226"}], "href": "https://doi.org/10.1111/febs.15226"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31985874"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31985874"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "E Santonico, F Belleudi, S Panni, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multiple modification and protein interaction signals drive the Ring finger protein 11 (RNF11) E3 ligase to the endosomal compartment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2010.294"}], "href": "https://doi.org/10.1038/onc.2010.294"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20676133"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20676133"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "E Kostaras, G Sflomos, N M Pedersen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SARA and RNF11 interact with each other and ESCRT-0 core proteins and regulate degradative EGFR trafficking."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2012.554"}], "href": "https://doi.org/10.1038/onc.2012.554"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23222715"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23222715"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "E Santonico, A Mattioni, S Panni, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNF11 is a GGA protein cargo and acts as a molecular adaptor for GGA3 ubiquitination mediated by Itch."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2014.256"}], "href": "https://doi.org/10.1038/onc.2014.256"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25195858"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25195858"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Sandra Scharaw, Murat Iskar, Alessandro Ori, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The endosomal transcriptional regulator RNF11 integrates degradation and transport of EGFR."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201601090"}], "href": "https://doi.org/10.1083/jcb.201601090"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27872256"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27872256"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Leah R Anderson, Ranjita Betarbet, Marla Gearing, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PARK10 candidate RNF11 is expressed by vulnerable neurons and localizes to Lewy bodies in Parkinson disease brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neuropathol Exp Neurol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/nen.0b013e3181567f17"}], "href": "https://doi.org/10.1097/nen.0b013e3181567f17"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17917589"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17917589"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Elaine L Pranski, Nirjari V Dalal, Jeremy H Herskowitz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neuronal RING finger protein 11 (RNF11) regulates canonical NF-κB signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neuroinflammation (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1742-2094-9-67"}], "href": "https://doi.org/10.1186/1742-2094-9-67"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22507528"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22507528"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Nirjari V Dalal, Elaine L Pranski, Malu G Tansey, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNF11 modulates microglia activation through NF-κB signalling cascade."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurosci Lett (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neulet.2012.08.060"}], "href": "https://doi.org/10.1016/j.neulet.2012.08.060"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22975135"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22975135"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Soratree Charoenthongtrakul, Linlin Gao, Kislay Parvatiyar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RING finger protein 11 targets TBK1/IKKi kinases to inhibit antiviral signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0053717"}], "href": "https://doi.org/10.1371/journal.pone.0053717"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23308279"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23308279"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Elaine Pranski, Carson D Van Sanford, Nirjari Dalal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NF-κB activity is inversely correlated to RNF11 expression in Parkinson's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurosci Lett (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neulet.2013.04.056"}], "href": "https://doi.org/10.1016/j.neulet.2013.04.056"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23669642"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23669642"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Johanna Scheper, Baldo Oliva, Jordi Villà-Freixa, et al. 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Synonyms	CGI-123, SID1669
Proteins	RNF11_HUMAN
NCBI Gene ID	26994
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RNF11 has 6,261 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 109 datasets.

Click the + buttons to view associations for RNF11 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RNF11 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RNF11 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of RNF11 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of RNF11 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RNF11 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RNF11 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RNF11 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RNF11 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RNF11 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of RNF11 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RNF11 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of RNF11 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with RNF11 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with RNF11 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RNF11 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RNF11 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RNF11 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RNF11 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RNF11 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing RNF11 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RNF11 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RNF11 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing RNF11 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RNF11 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RNF11 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with RNF11 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by RNF11 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with RNF11 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RNF11 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RNF11 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RNF11 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RNF11 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RNF11 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RNF11 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of RNF11 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing RNF11 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of RNF11 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with RNF11 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing RNF11 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of RNF11 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of RNF11 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.