RNF138 Gene

HGNC Family	Zinc fingers
Name	ring finger protein 138, E3 ubiquitin protein ligase
Description	The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRNF138 is a multifunctional RING‐finger E3 ubiquitin ligase that plays a critical role in maintaining genomic stability by orchestrating DNA double‐strand break repair. It facilitates homologous recombination through the timely ubiquitination of key repair factors—including CtIP and RAD51D—to promote DNA end resection, efficient RAD51 recruitment, and ATR‐dependent signaling. Moreover, RNF138 undergoes cell cycle–dependent post‐translational modifications, such as phosphorylation and auto‐ubiquitylation, processes that finely tune its activity during the repair of both simple and complex DNA lesions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its central role in DNA repair, RNF138 contributes to tumor biology and treatment response. In malignant contexts, dysregulated RNF138 expression is associated with resistance to cytotoxic therapies—it promotes radioresistance in glioblastoma, in part by mediating the ubiquitin‐dependent degradation of proteins like rpS3, and it is implicated in cisplatin resistance in gastric cancer by modulating cell cycle checkpoints and Chk1 phosphorylation. Furthermore, aberrant RNF138 activity has been linked to enhanced NF‑κB signaling in colorectal cancer and to impaired myeloid differentiation in acute myeloid leukemia through the targeted degradation of tumor suppressors such as C/EBPα."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRNF138 also influences diverse cellular processes beyond genome maintenance and oncogenesis. In the setting of viral infection, for example, the African swine fever virus exploits RNF138 to suppress type I interferon production through enhanced degradation of key signaling intermediates. In neurons, RNF138 regulates synaptic protein homeostasis by ubiquitinating the CaV2.1 channel subunit, thus affecting channel turnover and synaptic signaling. Its levels are modulated by microRNAs in oxidative injury models of trabecular meshwork cells, and through interaction with nuclear remodeling components such as SMARCC1, RNF138 helps restrain excessive inflammatory gene transcription. Collectively, these findings highlight RNF138 as a pivotal regulator at the crossroads of DNA repair, signal transduction, and cellular stress responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ismail Hassan Ismail, Jean-Philippe Gagné, Marie-Michelle Genois, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb3259"}], "href": "https://doi.org/10.1038/ncb3259"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26502055"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26502055"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Christine K Schmidt, Yaron Galanty, Matylda Sczaniecka-Clift, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb3260"}], "href": "https://doi.org/10.1038/ncb3260"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26502057"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26502057"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Brian D Yard, Nicole M Reilly, Michael K Bedenbaugh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNF138 interacts with RAD51D and is required for DNA interstrand crosslink repair and maintaining chromosome integrity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "DNA Repair (Amst) (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.dnarep.2016.04.006"}], "href": "https://doi.org/10.1016/j.dnarep.2016.04.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27161866"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27161866"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Deqiang Han, Junbo Liang, Yalan Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitylation of Rad51d Mediated by E3 Ligase Rnf138 Promotes the Homologous Recombination Repair Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0155476"}], "href": "https://doi.org/10.1371/journal.pone.0155476"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27195665"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27195665"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Nicole B Averbeck, Carina Barent, Burkhard Jakob, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Ubiquitin Ligase RNF138 Cooperates with CtIP to Stimulate Resection of Complex DNA Double-Strand Breaks in Human G1-Phase Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells11162561"}], "href": "https://doi.org/10.3390/cells11162561"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36010636"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36010636"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Andrew J Locke, Rabih Abou Farraj, Caroline Tran, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of RNF138 in DNA end resection is regulated by ubiquitylation and CDK phosphorylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jbc.2024.105709"}], "href": "https://doi.org/10.1016/j.jbc.2024.105709"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38309501"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38309501"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "You-xin Zhou, San-song Chen, Ting-feng Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel gene RNF138 expressed in human gliomas and its function in the glioma cell line U251."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anal Cell Pathol (Amst) (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/ACP-2011-0051"}], "href": "https://doi.org/10.3233/ACP-2011-0051"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22155992"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22155992"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Wanyeon Kim, HyeSook Youn, Sungmin Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNF138-mediated ubiquitination of rpS3 is required for resistance of glioblastoma cells to radiation-induced apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Mol Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emm.2017.247"}], "href": "https://doi.org/10.1038/emm.2017.247"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29371697"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29371697"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Haibin Wu, Xuetao Li, Ming Feng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of RNF138 inhibits cellular proliferation, migration, invasion and EMT in glioma cells via suppression of the Erk signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2018.6744"}], "href": "https://doi.org/10.3892/or.2018.6744"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30272353"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30272353"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yalan Lu, Rong Huang, Jianming Ying, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RING finger 138 deregulation distorts NF-кB signaling and facilities colitis switch to aggressive malignancy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Signal Transduct Target Ther (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41392-022-00985-1"}], "href": "https://doi.org/10.1038/s41392-022-00985-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35697692"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35697692"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Anil Kumar Singh, Vishal Upadhyay, Arppita Sethi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ring finger protein 138 inhibits transcription factor C/EBPα protein turnover leading to differentiation arrest in acute myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BCJ20240027"}], "href": "https://doi.org/10.1042/BCJ20240027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38666590"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38666590"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Ssu-Ju Fu, Chung-Jiuan Jeng, Chia-Hao Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitin Ligase RNF138 Promotes Episodic Ataxia Type 2-Associated Aberrant Degradation of Human Ca"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "v"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": "2.1 (P/Q-Type) Calcium Channels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.3070-16.2017"}], "href": "https://doi.org/10.1523/JNEUROSCI.3070-16.2017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28167673"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28167673"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Heting Liu, Yanghui Xiu, Qing Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing microRNA‑29b‑3p expression protects human trabecular meshwork cells against oxidative injury via upregulation of RNF138 to activate the ERK pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm.2021.4934"}], "href": "https://doi.org/10.3892/ijmm.2021.4934"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33907817"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33907817"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Li Huang, Wenjie Xu, Hongyang Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "African Swine Fever Virus pI215L Negatively Regulates cGAS-STING Signaling Pathway through Recruiting RNF138 to Inhibit K63-Linked Ubiquitination of TBK1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.2100320"}], "href": "https://doi.org/10.4049/jimmunol.2100320"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34759016"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34759016"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Wei Liu, Ziqiao Wang, Shuo Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2023.112097"}], "href": "https://doi.org/10.1016/j.celrep.2023.112097"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36800290"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36800290"}]}]}]}
Synonyms	STRIN, NARF, HSD-4, HNARF
Proteins	RN138_HUMAN
NCBI Gene ID	51444
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RNF138 has 6,392 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 112 datasets.

Click the + buttons to view associations for RNF138 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RNF138 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by RNF138 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RNF138 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of RNF138 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of RNF138 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RNF138 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RNF138 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RNF138 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RNF138 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RNF138 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RNF138 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of RNF138 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with RNF138 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with RNF138 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RNF138 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RNF138 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RNF138 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing RNF138 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RNF138 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RNF138 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing RNF138 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing RNF138 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing RNF138 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RNF138 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RNF138 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RNF138 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RNF138 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with RNF138 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of RNF138 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by RNF138 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RNF138 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RNF138 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RNF138 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RNF138 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RNF138 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RNF138 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of RNF138 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing RNF138 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with RNF138 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with RNF138 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of RNF138 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.