RNF19A Gene

HGNC Family	Zinc fingers
Name	ring finger protein 19A, RBR E3 ubiquitin protein ligase
Description	This gene encodes a member of the ring between ring fingers (RBR) protein family, and the encoded protein contains two RING-finger motifs and an in between RING fingers motif. This protein is an E3 ubiquitin ligase that is localized to Lewy bodies, and ubiquitylates synphilin-1, which is an interacting protein of alpha synuclein in neurons. The encoded protein may be involved in amyotrophic lateral sclerosis and Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRNF19A, also known as Dorfin, is a RING finger-type E3 ubiquitin ligase that plays a pivotal neuroprotective role in neurodegenerative disorders. In amyotrophic lateral sclerosis and Parkinson’s disease, RNF19A binds to mutant superoxide dismutase 1 and synphilin-1, catalyzing their ubiquitylation and promoting their proteasomal degradation. This process facilitates the clearance of misfolded protein aggregates, reduces their accumulation in cellular compartments such as mitochondria, and thereby alleviates downstream apoptotic and cytotoxic cascades."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its roles in neurodegeneration, RNF19A is implicated in oncogenesis and genomic maintenance. In non‐small cell lung cancer, RNF19A is frequently overexpressed and promotes tumor cell proliferation while suppressing apoptosis through the ubiquitin-dependent degradation of p53 and its downstream effectors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Moreover, in breast cancer, RNF19A suppresses homologous recombination by ubiquitinating BARD1, which disrupts the stabilization of the BRCA1–BARD1 complex and enhances sensitivity to poly(ADP‐ribose) polymerase inhibitors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Consistently, in prostate cancer, RNF19A acts as an oncogenic driver by ubiquitinating TRIP13, a process that is further potentiated by androgen receptor and HIF1A–mediated transcriptional activation, correlating with more aggressive disease and castration resistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRNF19A’s regulation extends beyond neurodegeneration and cancer. Alternative promoter usage and transcript variants—generated via retrotransposition events of MaLR and AluJo elements—contribute to its tissue-specific expression and subcellular localization, including its presence in pathological inclusions like Lewy bodies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Furthermore, in the context of sepsis, exosomal delivery of long noncoding RNA KCNQ1OT1 modulates the miR-154-3p/RNF19A axis, thereby mitigating cellular toxicity and improving survival outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jun-Ichi Niwa, Shinsuke Ishigaki, Nozomi Hishikawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M206559200"}], "href": "https://doi.org/10.1074/jbc.M206559200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12145308"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12145308"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Takashi Ito, Jun-Ichi Niwa, Nozomi Hishikawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M302763200"}], "href": "https://doi.org/10.1074/jbc.M302763200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12750386"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12750386"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Nozomi Hishikawa, Jun-Ichi Niwa, Manabu Doyu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dorfin localizes to the ubiquitylated inclusions in Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and amyotrophic lateral sclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0002-9440(10)63688-7"}], "href": "https://doi.org/10.1016/s0002-9440(10"}, {"type": "t", "text": "63688-7) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12875980"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12875980"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hideyuki Takeuchi, Jun-ichi Niwa, Nozomi Hishikawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dorfin prevents cell death by reducing mitochondrial localizing mutant superoxide dismutase 1 in a neuronal cell model of familial amyotrophic lateral sclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurochem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1046/j.1471-4159.2003.02289.x"}], "href": "https://doi.org/10.1046/j.1471-4159.2003.02289.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15030390"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15030390"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Shinsuke Ishigaki, Nozomi Hishikawa, Jun-ichi Niwa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Physical and functional interaction between Dorfin and Valosin-containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M406683200"}], "href": "https://doi.org/10.1074/jbc.M406683200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15456787"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15456787"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Shinsuke Ishigaki, Jun-ichi Niwa, Shin-ichi Yamada, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SOD1 proteins and reduce their cellular toxicity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Dis (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.nbd.2006.09.017"}], "href": "https://doi.org/10.1016/j.nbd.2006.09.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17157513"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17157513"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yu Cheng, Yujiao Hu, Huanxi Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ring finger protein 19A is overexpressed in non-small cell lung cancer and mediates p53 ubiquitin-degradation to promote cancer growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.16674"}], "href": "https://doi.org/10.1111/jcmm.16674"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34184814"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34184814"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Qian Zhu, Jinzhou Huang, Hongyang Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNF19A-mediated ubiquitination of BARD1 prevents BRCA1/BARD1-dependent homologous recombination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-021-27048-3"}], "href": "https://doi.org/10.1038/s41467-021-27048-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34789768"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34789768"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Ning Zhang, Da Huang, Xiaohao Ruan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CRISPR screening reveals gleason score and castration resistance related oncodriver ring finger protein 19 A (RNF19A) in prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Drug Resist Updat (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.drup.2022.100912"}], "href": "https://doi.org/10.1016/j.drup.2022.100912"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36623445"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36623445"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jae-Won Huh, Dae-Soo Kim, Hong-Seok Ha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cooperative exonization of MaLR and AluJo elements contributed an alternative promoter and novel splice variants of RNF19."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2008.07.030"}], "href": "https://doi.org/10.1016/j.gene.2008.07.030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18721867"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18721867"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Haojie Yuan, Junbo Yu, Chun Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA KCNQ10T1 shuttled by bone marrow mesenchymal stem cell-derived exosome inhibits sepsis via regulation of miR-154-3p/RNF19A axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Tissue Res (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00441-023-03784-4"}], "href": "https://doi.org/10.1007/s00441-023-03784-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37326687"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37326687"}]}]}]}
Synonyms	RNF19
Proteins	RN19A_HUMAN
NCBI Gene ID	25897
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RNF19A has 8,477 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 118 datasets.

Click the + buttons to view associations for RNF19A from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RNF19A Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RNF19A gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of RNF19A gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of RNF19A gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of RNF19A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RNF19A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RNF19A gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RNF19A gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RNF19A gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RNF19A gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of RNF19A gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RNF19A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of RNF19A gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with RNF19A gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RNF19A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RNF19A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RNF19A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of RNF19A gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RNF19A gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RNF19A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing RNF19A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RNF19A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RNF19A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RNF19A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RNF19A gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with RNF19A gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with RNF19A gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with RNF19A gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of RNF19A protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by RNF19A gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with RNF19A gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RNF19A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RNF19A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RNF19A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RNF19A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RNF19A gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RNF19A gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of RNF19A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing RNF19A from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with RNF19A gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of RNF19A gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.