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For example, in acute promyelocytic leukemia and studies on c‑Myc and PML nuclear bodies, RNF4 binds poly‑SUMOylated targets to mediate their ubiquitination and subsequent turnover, and it can even generate hybrid SUMO‑ubiquitin chains that serve as unique molecular signals for downstream effectors."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of the DNA damage response, RNF4 is rapidly recruited to sites of double‑strand breaks in a manner that depends on its SUMO interaction motifs. 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