RNF40 Gene

HGNC Family	Zinc fingers
Name	ring finger protein 40, E3 ubiquitin protein ligase
Description	The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRNF40 is a RING finger E3 ubiquitin ligase that functions as an obligate heterodimer with RNF20 to catalyze the monoubiquitination of histone H2B at lysine 120. This histone modification is closely coupled to active transcription, facilitating chromatin decondensation, transcriptional elongation, and crosstalk with downstream histone marks that regulate key developmental and differentiation gene programs. Such epigenetic regulation is fundamental for proper gene expression, as evidenced by its stimulation of HOX gene expression and other transcription‐dependent processes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in transcription, RNF40 is a critical component of the DNA damage response. Its deposition of H2Bub1 at sites of DNA double-strand breaks promotes chromatin remodeling and facilitates the timely recruitment of repair factors, thereby ensuring efficient activation of cell cycle checkpoints and homologous recombination processes. The impairment of RNF40 activity leads to sustained DNA damage signals and genomic instability, underscoring its importance in preserving genome integrity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRNF40’s function extends into the realm of oncogenesis and cell cycle regulation, where it can exhibit context‐dependent roles. In various cancer models—including prostate, ovarian, and breast cancers—RNF40 modulates hormone receptor–driven transcription (such as androgen receptor signaling), supports proper spindle assembly during mitosis, and promotes the expression of cell cycle regulators. In addition, RNF40 influences stress‐responsive transcription through nonhistone targets (for example, by monoubiquitinating factors that augment heat shock gene transcription), participates in p53-dependent regulatory pathways, and cooperates with chromatin chaperones to facilitate HIF-1 target gene expression. In aggressive breast cancer subtypes, such as HER2-positive and triple-negative tumors, RNF40 contributes to the activation of oncogenic pathways—including RHO/ROCK/LIMK cascades and pro-tumorigenic YAP1 signaling—that support cancer stem cell properties and tumor growth. Moreover, RNF40 loss or deregulation has been implicated in inflammatory-driven colorectal tumor progression, highlighting its multifaceted involvement in tumor biology."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRNF40 also plays an essential role during cell state transitions. It is required for early reprogramming processes in induced pluripotent stem cell generation, where its activity helps resolve bivalent chromatin domains on pluripotency genes. This epigenetic function ensures the proper activation of genes essential for resetting somatic cell identity while concomitantly enforcing tissue-specific gene silencing."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Bing Zhu, Yong Zheng, Anh-Dung Pham, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2005.09.025"}], "href": "https://doi.org/10.1016/j.molcel.2005.09.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16307923"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16307923"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Sophia B Chernikova, Olga V Razorenova, John P Higgins, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deficiency in mammalian histone H2B ubiquitin ligase Bre1 (Rnf20/Rnf40) leads to replication stress and chromosomal instability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-11-2209"}], "href": "https://doi.org/10.1158/0008-5472.CAN-11-2209"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22354749"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22354749"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Bingbing Pan, Zhaokang Yuan, Jiaojiao Zou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elderly hospitalization and the New-type Rural Cooperative Medical Scheme (NCMS) in China: multi-stage cross-sectional surveys of Jiangxi province."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Health Serv Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12913-016-1638-5"}], "href": "https://doi.org/10.1186/s12913-016-1638-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27557644"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27557644"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Junjiang Fu, Li Liao, Kyathegowdanadoddi Srinivasa Balaji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic modification and a role for the E3 ligase RNF40 in cancer development and metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-020-01556-w"}], "href": "https://doi.org/10.1038/s41388-020-01556-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33199825"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33199825"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Sophia B Chernikova, Jennifer A Dorth, Olga V Razorenova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deficiency in Bre1 impairs homologous recombination repair and cell cycle checkpoint response to radiation damage in mammalian cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Radiat Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1667/RR2184.1"}], "href": "https://doi.org/10.1667/RR2184.1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20738173"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20738173"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yosef Shiloh, Efrat Shema, Lilach Moyal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNF20-RNF40: A ubiquitin-driven link between gene expression and the DNA damage response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2011.07.034"}], "href": "https://doi.org/10.1016/j.febslet.2011.07.034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21827756"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21827756"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Vijayalakshmi Kari, Andrei Shchebet, Heinz Neumann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The H2B ubiquitin ligase RNF40 cooperates with SUPT16H to induce dynamic changes in chromatin structure during DNA double-strand break repair."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cc.10.20.17769"}], "href": "https://doi.org/10.4161/cc.10.20.17769"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22031019"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22031019"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Chen Wu, Yaqi Cui, Xiuhua Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The RNF20/40 complex regulates p53-dependent gene transcription and mRNA splicing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Cell Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jmcb/mjz045"}], "href": "https://doi.org/10.1093/jmcb/mjz045"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31152661"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31152661"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Tiina Jääskeläinen, Harri Makkonen, Tapio Visakorpi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Histone H2B ubiquitin ligases RNF20 and RNF40 in androgen signaling and prostate cancer cell growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Endocrinol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mce.2011.11.025"}], "href": "https://doi.org/10.1016/j.mce.2011.11.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22155569"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22155569"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yang Duan, Dawei Huo, Jie Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitin ligase RNF20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein Eg5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms12648"}], "href": "https://doi.org/10.1038/ncomms12648"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27557628"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27557628"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Kristie-Ann Dickson, Alexander J Cole, Anthony J Gill, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The RING finger domain E3 ubiquitin ligases BRCA1 and the RNF20/RNF40 complex in global loss of the chromatin mark histone H2B monoubiquitination (H2Bub1) in cell line models and primary high-grade serous ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddw362"}], "href": "https://doi.org/10.1093/hmg/ddw362"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27798111"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27798111"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Robyn Laura Kosinsky, Robert Lorenz Chua, Martin Qui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of RNF40 Decreases NF-κB Activity in Colorectal Cancer Cells and Reduces Colitis Burden in Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Crohns Colitis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/ecco-jcc/jjy165"}], "href": "https://doi.org/10.1093/ecco-jcc/jjy165"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30321325"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30321325"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Suna In, Yong-In Kim, J Eugene Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNF20/40-mediated eEF1BδL monoubiquitylation stimulates transcription of heat shock-responsive genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkz006"}], "href": "https://doi.org/10.1093/nar/gkz006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30649429"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30649429"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Deborah Schneider, Robert Lorenz Chua, Nicole Molitor, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The E3 ubiquitin ligase RNF40 suppresses apoptosis in colorectal cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Epigenetics (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13148-019-0698-x"}], "href": "https://doi.org/10.1186/s13148-019-0698-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31266541"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31266541"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Florian Wegwitz, Evangelos Prokakis, Anastasija Pejkovska, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "RNF40 epigenetically modulates glycolysis to support the aggressiveness of basal-like breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-023-06157-5"}], "href": "https://doi.org/10.1038/s41419-023-06157-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37770435"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37770435"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Yajing Lyu, Yongkang Yang, Varen Talwar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to mediate histone ubiquitination and transcriptional activation of target genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2024.113972"}], "href": "https://doi.org/10.1016/j.celrep.2024.113972"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38517892"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38517892"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Wanhua Xie, Michaela Miehe, Sandra Laufer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The H2B ubiquitin-protein ligase RNF40 is required for somatic cell reprogramming."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-2482-4"}], "href": "https://doi.org/10.1038/s41419-020-2482-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32341358"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32341358"}]}]}]}
Synonyms	RBP95, STARING, BRE1B
Proteins	BRE1B_HUMAN
NCBI Gene ID	9810
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RNF40 has 5,702 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 119 datasets.

Click the + buttons to view associations for RNF40 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RNF40 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by RNF40 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RNF40 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of RNF40 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of RNF40 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of RNF40 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RNF40 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RNF40 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RNF40 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RNF40 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RNF40 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of RNF40 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RNF40 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of RNF40 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with RNF40 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with RNF40 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RNF40 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RNF40 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RNF40 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RNF40 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RNF40 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing RNF40 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RNF40 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RNF40 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing RNF40 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RNF40 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RNF40 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with RNF40 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with RNF40 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by RNF40 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with RNF40 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RNF40 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RNF40 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RNF40 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RNF40 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RNF40 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RNF40 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of RNF40 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing RNF40 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of RNF40 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with RNF40 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.