RNF7 Gene

HGNC Family	Zinc fingers
Name	ring finger protein 7
Description	The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRNF7, also known as SAG, ROC2, or RBX2, is a highly conserved RING finger protein functioning as an essential component of Cullin-RING E3 ubiquitin ligases (CRLs) such as the SCF complex. In this role, RNF7 facilitates the ubiquitination and subsequent proteasomal degradation of numerous regulatory proteins—including pro-caspase‐3 and cell cycle inhibitors like p21 and p27—by partnering with specific E2 ubiquitin‐conjugating enzymes that determine the type of polyubiquitin linkage. In addition, RNF7 exhibits antioxidant properties mediated by its peroxidase activity; its sulfhydryl groups can directly neutralize hydrogen peroxide and related reactive oxygen species, thereby contributing to its redox‐inducible, anti‐apoptotic functions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBy regulating the removal of key proteins that control cell cycle progression and apoptosis, RNF7 plays a critical role in setting the apoptotic threshold and promoting cell survival. Its ubiquitin ligase activity not only lowers basal levels of caspase precursors but also facilitates the degradation of tumor suppressor molecules, thereby enhancing cellular resistance to stresses such as ionizing radiation and chemotherapeutic agents. These mechanisms have been implicated in a variety of human cancers—including lung, prostate, renal, and pancreatic malignancies—where RNF7 overexpression correlates with tumor progression and poor prognosis, highlighting its potential as an oncogene and therapeutic target."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "17"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its core E3 ligase functions, RNF7 engages in broader network interactions that further influence vital cellular processes. It interacts with proliferating cell nuclear antigen (PCNA), suggesting a potential role in modulating DNA replication and repair, and it also binds to adaptor proteins such as CARMA2 to impact NF‐κB signaling by altering the ubiquitination status of key regulators. Furthermore, genetic polymorphisms in the RNF7 gene have been associated with liver fibrosis in chronic hepatitis C patients, and novel high‐resolution genotyping assays now target such variants—underscoring the clinical relevance of RNF7 in both inflammatory and neoplastic disease pathogenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "18", "end_ref": "21"}]}, {"type": "t", "text": ""}]}]}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sun Yee Kim, Young Seuk Bae, Jeen-Woo Park "}, {"type": "b", "children": [{"type": "t", "text": "Thiol-linked peroxidase activity of human sensitive to apoptosis gene (SAG) protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Free Radic Res (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/10715760210164"}], "href": "https://doi.org/10.1080/10715760210164"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11999705"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11999705"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yun-Sook Kim, Kwon-Soo Ha, Young-Ho Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Ring-H2 finger motif of CKBBP1/SAG is necessary for interaction with protein kinase CKII and optimal cell proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem Mol Biol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.5483/bmbrep.2002.35.6.629"}], "href": "https://doi.org/10.5483/bmbrep.2002.35.6.629"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12470599"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12470599"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Sun Yee Kim, Jin Hyup Lee, Eun Sun Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human sensitive to apoptosis gene protein inhibits peroxynitrite-induced DNA damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0006-291x(03)00018-4"}], "href": "https://doi.org/10.1016/s0006-291x(03"}, {"type": "t", "text": "00018-4) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12565832"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12565832"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yun-Sook Kim, Jae-Yong Lee, Mi-Young Son, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation of threonine 10 on CKBBP1/SAG/ROC2/Rbx2 by protein kinase CKII promotes the degradation of IkappaBalpha and p27Kip1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M302584200"}], "href": "https://doi.org/10.1074/jbc.M302584200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12748192"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12748192"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hongbin He, Mingjia Tan, Deepika Pamarthy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CK2 phosphorylation of SAG at Thr10 regulates SAG stability, but not its E3 ligase activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-006-9287-3"}], "href": "https://doi.org/10.1007/s11010-006-9287-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16874460"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16874460"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Mingjia Tan, Jayme R Gallegos, Qingyang Gu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SAG/ROC-SCF beta-TrCP E3 ubiquitin ligase promotes pro-caspase-3 degradation as a mechanism of apoptosis protection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasia (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1593/neo.06568"}], "href": "https://doi.org/10.1593/neo.06568"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17217622"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17217622"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "M Tan, Q Gu, H He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SAG/ROC2/RBX2 is a HIF-1 target gene that promotes HIF-1 alpha ubiquitination and degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1210780"}], "href": "https://doi.org/10.1038/sj.onc.1210780"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17828303"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17828303"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Sun Joo Lee, Eun Sun Yang, Sun Yee Kim, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Prognostic role of sensitive-to-apoptosis gene expression in rectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Gastroenterol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3748/wjg.v17.i44.4905"}], "href": "https://doi.org/10.3748/wjg.v17.i44.4905"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22171132"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22171132"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Weihua Zhou, Jie Xu, Yongchao Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SAG/RBX2 is a novel substrate of NEDD4-1 E3 ubiquitin ligase and mediates NEDD4-1 induced chemosensitization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.2246"}], "href": "https://doi.org/10.18632/oncotarget.2246"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25216516"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25216516"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Xiaodan Wang, Xiaoying Wang, Weiran Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Both Rbx1 and Rbx2 exhibit a functional role in the HIV-1 Vif-Cullin5 E3 ligase complex in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2015.04.077"}], "href": "https://doi.org/10.1016/j.bbrc.2015.04.077"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25912140"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25912140"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Yangjiong Xiao, Yan Jiang, Hongmei Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNF7 knockdown inhibits prostate cancer tumorigenesis by inactivation of ERK1/2 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep43683"}], "href": "https://doi.org/10.1038/srep43683"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28252001"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28252001"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Juozas Kupcinskas, Irena Valantiene, Greta Varkalaitė, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PNPLA3 and RNF7 Gene Variants are Associated with the Risk of Developing Liver Fibrosis and Cirrhosis in an Eastern European Population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gastrointestin Liver Dis (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15403/jgld.2014.1121.261.pnp"}], "href": "https://doi.org/10.15403/jgld.2014.1121.261.pnp"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28338112"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28338112"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Chengwu Xiao, Wei Zhang, Meimian Hua, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNF7 inhibits apoptosis and sunitinib sensitivity and promotes glycolysis in renal cell carcinoma via the SOCS1/JAK/STAT3 feedback loop."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Biol Lett (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s11658-022-00337-5"}], "href": "https://doi.org/10.1186/s11658-022-00337-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35562668"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35562668"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Hao Hua, Huahua Xie, Jian Zheng, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Triplex High-Resolution Melting Assay for the Simultaneous Assessment of IFNL3 rs12979860, ABCB11 rs2287622, and RNF7 rs16851720 Genotypes in Chronic Hepatitis C Patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Diagn (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmoldx.2017.07.005"}], "href": "https://doi.org/10.1016/j.jmoldx.2017.07.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28860020"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28860020"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Gianluca Telesio, Ivan Scudiero, Maddalena Pizzulo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The E3 Ubiquitin Ligase RNF7 Negatively Regulates CARD14/CARMA2sh Signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms18122581"}], "href": "https://doi.org/10.3390/ijms18122581"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29194363"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29194363"}]}]}]}
Synonyms	CKBBP1, rbx2
Proteins	RBX2_HUMAN
NCBI Gene ID	9616
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RNF7 has 6,737 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 118 datasets.

Click the + buttons to view associations for RNF7 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RNF7 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by RNF7 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RNF7 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of RNF7 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of RNF7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RNF7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RNF7 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RNF7 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RNF7 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RNF7 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RNF7 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of RNF7 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with RNF7 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with RNF7 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RNF7 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RNF7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RNF7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RNF7 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RNF7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing RNF7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing RNF7 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RNF7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RNF7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing RNF7 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RNF7 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RNF7 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with RNF7 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with RNF7 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of RNF7 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by RNF7 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with RNF7 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RNF7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RNF7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RNF7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RNF7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RNF7 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RNF7 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of RNF7 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing RNF7 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of RNF7 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with RNF7 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.