ROBO3 Gene

HGNC Family	Immunoglobulin superfamily domain containing, Fibronectin type III domain containing
Name	roundabout, axon guidance receptor, homolog 3 (Drosophila)
Description	This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS); an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. [provided by RefSeq, May 2019]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nROBO3 is a critical axon guidance receptor that orchestrates midline crossing during central nervous system development. Its proper function ensures that corticospinal and somatosensory axons decussate appropriately—a process that, when disrupted by mutations in ROBO3, underlies the clinical syndrome of horizontal gaze palsy with progressive scoliosis (HGPPS). Multiple studies have documented that ROBO3 mutations impede the normal crossing of hindbrain axons, as demonstrated in patients with HGPPS whose genetic defects affect distinct regions of the receptor. In addition, molecular analyses have revealed that ROBO3 exists in different isoforms with unique binding properties to Slit ligands and other Robo family members; such interactions are essential for regulating the cellular response to repulsive guidance cues, in part by modulating the cell surface expression of related receptors. These insights have been established through clinical case series, review articles, and mechanistic studies that collectively expand our understanding of ROBO3’s role in neural pathway development."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its developmental role, ROBO3 has been implicated in the modulation of neuronal signaling pathways and neuropsychiatric conditions. For example, genetic association studies have linked ROBO3 variants with autism, suggesting that alterations in this gene may affect serotonergic neurotransmission and broader aspects of neurodevelopment. At the molecular level, ROBO3 participates in intracellular signaling networks through its interaction with anchoring proteins such as AKAP79/150; these complexes contribute to local kinase activities and phosphorylation events in brain regions involved in learning and memory. Notably, while investigations into other neuropsychiatric disorders (for instance, in analyses of Tourette syndrome) have not supported a significant role for ROBO3, such studies nonetheless underscore the complex and context‐dependent influence of this receptor on brain function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond neurodevelopment, aberrant ROBO3 expression has emerged as an important factor in oncogenesis. In pancreatic carcinoma, for instance, overexpression of ROBO3 appears to facilitate tumor cell growth, invasion, and metastasis by modulating the Wnt/β-catenin signaling pathway—potentially through sequestration of inhibitory molecules such as SFRP. Similarly, in hematologic malignancies and basal-like breast cancer, elevated levels of ROBO3, including a novel short isoform (ROBO3s) that lacks a transmembrane domain, activate proliferative and survival pathways such as Hippo-YAP, thereby promoting chemoresistance and aggressive tumor behavior. These findings suggest that ROBO3 may serve not only as a prognostic biomarker but also as a potential therapeutic target in various cancers."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Joanna C Jen, Wai-Man Chan, Thomas M Bosley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in a human ROBO gene disrupt hindbrain axon pathway crossing and morphogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1096437"}], "href": "https://doi.org/10.1126/science.1096437"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15105459"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15105459"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "T M Bosley, M A M Salih, J C Jen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neurologic features of horizontal gaze palsy and progressive scoliosis with mutations in ROBO3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurology (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1212/01.WNL.0000156349.01765.2B"}], "href": "https://doi.org/10.1212/01.WNL.0000156349.01765.2B"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15824346"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15824346"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "W-M Chan, E I Traboulsi, B Arthur, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Horizontal gaze palsy with progressive scoliosis can result from compound heterozygous mutations in ROBO3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Genet (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jmg.2005.035436"}], "href": "https://doi.org/10.1136/jmg.2005.035436"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16525029"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16525029"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Laura Camurri, Elvira Mambetisaeva, Derek Davies, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evidence for the existence of two Robo3 isoforms with divergent biochemical properties."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Neurosci (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mcn.2005.07.014"}], "href": "https://doi.org/10.1016/j.mcn.2005.07.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16226035"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16226035"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Khaled K Abu-Amero, Hesham al Dhalaan, Zayed al Zayed, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Five new consanguineous families with horizontal gaze palsy and progressive scoliosis and novel ROBO3 mutations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurol Sci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jns.2008.08.026"}], "href": "https://doi.org/10.1016/j.jns.2008.08.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18829051"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18829051"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Alexander E Volk, Oliver Carter, Julia Fricke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Horizontal gaze palsy with progressive scoliosis: three novel ROBO3 mutations and descriptions of the phenotypes of four patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Vis (2011)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21850172"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21850172"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Arif O Khan, Khaled Abu-Amero "}, {"type": "b", "children": [{"type": "t", "text": "Infantile esotropia with cross-fixation, inability to abduct, and underlying horizontal gaze palsy with progressive scoliosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J AAPOS (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jaapos.2014.02.011"}], "href": "https://doi.org/10.1016/j.jaapos.2014.02.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24969490"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24969490"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yanghui Xiu, Zhe Lv, Danni Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Introducing and Reviewing a Novel Mutation of ROBO3 in Horizontal Gaze Palsy with Progressive Scoliosis from a Chinese Family."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Neurosci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12031-020-01650-4"}], "href": "https://doi.org/10.1007/s12031-020-01650-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32705527"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32705527"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Elena Pinero-Pinto, Verónica Pérez-Cabezas, Cristina Tous-Rivera, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutation in "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "ROBO"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "3 Gene in Patients with Horizontal Gaze Palsy with Progressive Scoliosis Syndrome: A Systematic Review."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Environ Res Public Health (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijerph17124467"}], "href": "https://doi.org/10.3390/ijerph17124467"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32580277"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32580277"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Liqa A Rousan, Abu Baker L Qased, Ziad A Audat, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Horizontal gaze palsy and progressive scoliosis with two novel ROBO3 gene mutations in two Jordanian families."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ophthalmic Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/13816810.2019.1592199"}], "href": "https://doi.org/10.1080/13816810.2019.1592199"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30985235"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30985235"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Arif O Khan, Darren T Oystreck, Nada Al-Tassan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bilateral synergistic convergence associated with homozygous ROB03 mutation (p.Pro771Leu)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ophthalmology (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ophtha.2008.08.010"}], "href": "https://doi.org/10.1016/j.ophtha.2008.08.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19041479"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19041479"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Khaled K Abu-Amero, Seema Kapoor, Ali Hellani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Horizontal gaze palsy and progressive scoliosis due to a deleterious mutation in ROBO3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ophthalmic Genet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/13816810.2011.580445"}], "href": "https://doi.org/10.3109/13816810.2011.580445"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21592015"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21592015"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Bret K Samelson, Bryan B Gore, Jennifer L Whiting, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A-kinase Anchoring Protein 79/150 Recruits Protein Kinase C to Phosphorylate Roundabout Receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M115.637470"}], "href": "https://doi.org/10.1074/jbc.M115.637470"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25882844"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25882844"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "A Anitha, Kazuhiko Nakamura, Kazuo Yamada, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic analyses of roundabout (ROBO) axon guidance receptors in autism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet B Neuropsychiatr Genet (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.b.30697"}], "href": "https://doi.org/10.1002/ajmg.b.30697"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18270976"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18270976"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "D M Miranda, K Wigg, Y Feng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association study between Gilles de la Tourette Syndrome and two genes in the Robo-Slit pathway located in the chromosome 11q24 linked/associated region."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet B Neuropsychiatr Genet (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.b.30580"}], "href": "https://doi.org/10.1002/ajmg.b.30580"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17671968"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17671968"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Shilong Han, Chuanwu Cao, Tao Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ROBO3 promotes growth and metastasis of pancreatic carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2015.06.004"}], "href": "https://doi.org/10.1016/j.canlet.2015.06.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26070964"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26070964"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Niklas Krebs, Lukas Klein, Florian Wegwitz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Axon guidance receptor ROBO3 modulates subtype identity and prognosis via AXL-associated inflammatory network in pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "JCI Insight (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/jci.insight.154475"}], "href": "https://doi.org/10.1172/jci.insight.154475"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35993361"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35993361"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Man-Si Cai, Ai-Ling Luo, Xiao-Ping Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Expression of ROBO3 and Its Effect on Cell Proliferation and Apoptosis in Pediatric Patients with Acute Myeloid Leukemia]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhongguo Shi Yan Xue Ye Xue Za Zhi (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.19746/j.cnki.issn.1009-2137.2022.05.004"}], "href": "https://doi.org/10.19746/j.cnki.issn.1009-2137.2022.05.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36208230"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36208230"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Chaonan Li, Zhen Wang, Binghui Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of ROBO3 promotes proliferation, migration and adhesion of AML cells and affects the survival of AML patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2023.04.030"}], "href": "https://doi.org/10.1016/j.bbrc.2023.04.030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37084487"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37084487"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Marcel Werner, Anna Dyas, Iwan Parfentev, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ROBO3s: a novel ROBO3 short isoform promoting breast cancer aggressiveness."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-022-05197-7"}], "href": "https://doi.org/10.1038/s41419-022-05197-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36057630"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36057630"}]}]}]}
Synonyms	RBIG1, HGPPS1, HGPPS
Proteins	ROBO3_HUMAN
NCBI Gene ID	64221
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ROBO3 has 5,566 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 119 datasets.

Click the + buttons to view associations for ROBO3 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ROBO3 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by ROBO3 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ROBO3 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ROBO3 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ROBO3 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ROBO3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ROBO3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ROBO3 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ROBO3 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ROBO3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ROBO3 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ROBO3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ROBO3 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ROBO3 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ROBO3 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ROBO3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ROBO3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with ROBO3 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with ROBO3 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ROBO3 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ROBO3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ROBO3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ROBO3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ROBO3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ROBO3 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ROBO3 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ROBO3 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ROBO3 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of ROBO3 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ROBO3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with ROBO3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ROBO3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ROBO3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ROBO3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ROBO3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ROBO3 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ROBO3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ROBO3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ROBO3 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with ROBO3 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of ROBO3 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.