{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRibosomal protein L11 (RPL11) is an essential component of the 60S ribosomal subunit that exerts critical extra‐ribosomal functions by acting as a sensor of ribosomal and nucleolar stress. Under conditions that impair ribosome biogenesis or induce DNA damage, RPL11 translocates from the nucleolus into the nucleoplasm where it binds directly to MDM2 (and even to a specific zinc‐finger domain of MDM2), thereby suppressing MDM2’s ubiquitin ligase activity and preventing p53 degradation. In doing so, RPL11 facilitates the stabilization and activation of p53—and even of the p53 family member TAp73—to promote cell cycle arrest and apoptosis as well as to coordinate the transcriptional recruitment of co‐activators such as p300/CBP at p53 target gene promoters. This regulatory signaling is further modulated by post‐translational modifications (for example, by NEDDylation) and is influenced by specific MDM2 mutations that disrupt RPL11 binding."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in the p53-mediated stress response, RPL11 serves as a crucial negative regulator of the oncogene c-Myc. By directly interacting with c-myc mRNA—including recruiting microRNA-containing complexes and impeding the binding of transcriptional coactivators such as TRRAP—RPL11 limits c-Myc transcriptional output and oncogenic activity. This dual capacity to both sense ribosomal stress and temper c-Myc expression underscores a feedback mechanism that tightly controls ribosomal biogenesis and cell proliferation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "17", "end_ref": "22"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMutations or haploinsufficiencies in RPL11 have been implicated in human disorders such as Diamond–Blackfan anemia (DBA), where they are associated with congenital malformations (notably, isolated thumb defects), growth retardation, and defective erythropoiesis. Furthermore, RPL11 deficiency or altered expression perturbs the balance of ribosomal subunit synthesis and global translation, thereby compromising normal cell proliferation and contributing to tumorigenesis in certain contexts. Transcriptional regulation (for example, via YY1) and proper ribosome assembly depend on RPL11 levels, emphasizing its pivotal roles both within the ribosome and as an extra-ribosomal modulator of cell homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "23", "end_ref": "33"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yanping Zhang, Gabrielle White Wolf, Krishna Bhat, et al. 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