RPL26 Gene

HGNC Family	L ribosomal proteins (RPL)
Name	ribosomal protein L26
Description	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L24P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Mutations in this gene result in Diamond-Blackfan anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRibosomal protein L26 (RPL26) operates as a key positive regulator of the p53 tumor suppressor by binding directly to the messenger RNA’s untranslated regions to enhance its translation. Under nonstressed conditions, the E3 ubiquitin ligase Mdm2 both degrades RPL26 and prevents its association with p53 mRNA, thereby maintaining low p53 levels; however, upon genotoxic stress this inhibition is relieved, permitting RPL26 to drive rapid p53 protein synthesis. RPL26 also antagonizes translational repressors such as nucleolin and interferes with microRNA‐mediated silencing of p53, ensuring robust p53 induction when cellular stress demands it."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its regulatory role in p53 expression, a mutation in RPL26 has been implicated in Diamond–Blackfan anemia. A de novo two-nucleotide deletion in RPL26 was found to cause significant defects in ribosome biogenesis—disrupting the maturation of both the small and large ribosomal subunits—and further delineates RPL26 as one of the ribosomal proteins linking aberrant ribosome assembly with altered p53 activity and congenital malformations."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond p53 control, RPL26 contributes to the broader DNA-damage response by influencing alternative splicing and the expression of other tumor suppressors such as p73. In response to ionizing radiation, inhibition of SMG1 enables RPL26 to bind p53 pre-mRNA and promote the recruitment of splicing factors that generate alternatively spliced isoforms, while RPL26 also facilitates p73 mRNA translation by interacting with the cap-binding protein eIF4E to enhance polysome assembly. Moreover, studies in pancreatic cancer models have demonstrated that upregulation of RPL26 supports cell cycle progression and modulates reactive oxygen species production, underscoring its impact on tumorigenesis. Collectively, these findings position RPL26 as a pivotal mediator of translational control in stress responses, with broad implications for tumor suppressor regulation and disease."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yaara Ofir-Rosenfeld, Kristy Boggs, Dan Michael, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2008.08.031"}], "href": "https://doi.org/10.1016/j.molcel.2008.08.031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18951086"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18951086"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jing Chen, Kexiao Guo, Michael B Kastan "}, {"type": "b", "children": [{"type": "t", "text": "Interactions of nucleolin and ribosomal protein L26 (RPL26) in translational control of human p53 mRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.349274"}], "href": "https://doi.org/10.1074/jbc.M112.349274"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22433872"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22433872"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Christina G Towers, Anna L Guarnieri, Doug S Micalizzi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Six1 oncoprotein downregulates p53 via concomitant regulation of RPL26 and microRNA-27a-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms10077"}], "href": "https://doi.org/10.1038/ncomms10077"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26687066"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26687066"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hanna T Gazda, Milena Preti, Mee Rie Sheen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Frameshift mutation in p53 regulator RPL26 is associated with multiple physical abnormalities and a specific pre-ribosomal RNA processing defect in diamond-blackfan anemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.22081"}], "href": "https://doi.org/10.1002/humu.22081"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22431104"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22431104"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jing Chen, John Crutchley, Dadong Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a DNA Damage-Induced Alternative Splicing Pathway That Regulates p53 and Cellular Senescence Markers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Discov (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/2159-8290.CD-16-0908"}], "href": "https://doi.org/10.1158/2159-8290.CD-16-0908"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28288992"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28288992"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Chaodong Li, Mei Ge, Yu Yin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing expression of ribosomal protein L26 and L29 by RNA interfering inhibits proliferation of human pancreatic cancer PANC-1 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-012-1404-x"}], "href": "https://doi.org/10.1007/s11010-012-1404-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22868929"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22868929"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Min Zhang, Jin Zhang, Wensheng Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p73 expression is regulated by ribosomal protein RPL26 through mRNA translation and protein stability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.13126"}], "href": "https://doi.org/10.18632/oncotarget.13126"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27825141"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27825141"}]}]}]}
Synonyms	L26, DBA11
Proteins	RL26_HUMAN
NCBI Gene ID	6154
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RPL26 has 10,632 functional associations with biological entities spanning 8 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 114 datasets.

Click the + buttons to view associations for RPL26 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RPL26 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RPL26 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of RPL26 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RPL26 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RPL26 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RPL26 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RPL26 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RPL26 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RPL26 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with RPL26 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with RPL26 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RPL26 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RPL26 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RPL26 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with RPL26 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RPL26 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RPL26 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing RPL26 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing RPL26 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing RPL26 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RPL26 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RPL26 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing RPL26 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RPL26 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RPL26 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with RPL26 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with RPL26 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of RPL26 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving RPL26 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving RPL26 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RPL26 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RPL26 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RPL26 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RPL26 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RPL26 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RPL26 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of RPL26 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing RPL26 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with RPL26 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing RPL26 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of RPL26 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.