RPL36A-HNRNPH2 Gene

Name RPL36A-HNRNPH2 readthrough
Description This locus represents naturally occurring read-through transcription between the neighboring ribosomal protein L36a and heterogeneous nuclear ribonucleoprotein H2 (H') genes on chromosome X. The read-through transcript produces a protein with similarity to the protein encoded by the upstream locus, ribosomal protein L36a. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jan 2011]
Summary
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In various in vivo and in vitro models of inflammation, loss of annexin A1 leads to excessive leukocyte recruitment and impaired resolution, highlighting its role in restoring tissue homeostasis through the induction of cell clearance and dampening proinflammatory signals."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAt the molecular level, annexin A1 acts through binding to specific G‐protein–coupled formyl peptide receptors (FPRs) to trigger downstream signaling events that curb inflammation. Its engagement with these receptors facilitates neutrophil apoptosis, enhances the phagocytic clearance (efferocytosis) of dying cells by macrophages, and modulates key intracellular pathways such as MAPK, RhoA–ROCK, and AMPK. Moreover, annexin A1 is secreted via nonclassical mechanisms—often involving ATP-binding cassette transporters—to mediate intercellular cross-talk essential for resolution of inflammation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond controlling early immune responses, annexin A1 plays a multifaceted role in maintaining and restoring tissue integrity. It supports endothelial barrier function—including the blood–brain barrier—and participates in vascular remodeling, wound healing, and even processes such as tumor angiogenesis and epithelial–mesenchymal transitions in cancer. In experimental models of ischemia, diabetic injury, and neuroinflammation, administration of annexin A1 or its mimetic peptides ameliorates tissue damage by promoting proresolving macrophage polarization and restoring cellular homeostasis. These findings underscore its potential as a therapeutic target to resolve chronic inflammation and facilitate tissue regeneration."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "20", "end_ref": "37"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Felicity N E Gavins, Simon Yona, Ahmad M Kamal, et al. 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NCBI Gene ID 100529097
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Predicted Functions View RPL36A-HNRNPH2's ARCHS4 Predicted Functions.
Co-expressed Genes View RPL36A-HNRNPH2's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View RPL36A-HNRNPH2's ARCHS4 Predicted Functions.

Functional Associations

RPL36A-HNRNPH2 has 2,113 functional associations with biological entities spanning 6 categories (molecular profile, disease, phenotype or trait, functional term, phrase or reference, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 31 datasets.

Click the + buttons to view associations for RPL36A-HNRNPH2 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles tissue samples with high or low expression of RPL36A-HNRNPH2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of RPL36A-HNRNPH2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Targets 2022 transcription factors binding the promoter of RPL36A-HNRNPH2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
ClinVar Gene-Phenotype Associations 2025 phenotypes associated with RPL36A-HNRNPH2 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 cellular components containing RPL36A-HNRNPH2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with RPL36A-HNRNPH2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of RPL36A-HNRNPH2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with RPL36A-HNRNPH2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
DisGeNET Gene-Disease Associations diseases associated with RPL36A-HNRNPH2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at RPL36A-HNRNPH2 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of RPL36A-HNRNPH2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of RPL36A-HNRNPH2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
HPA Cell Line Gene Expression Profiles cell lines with high or low expression of RPL36A-HNRNPH2 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset.
HPA Tissue Protein Expression Profiles tissues with high or low expression of RPL36A-HNRNPH2 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset.
JASPAR Predicted Human Transcription Factor Targets 2025 transcription factors regulating expression of RPL36A-HNRNPH2 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of RPL36A-HNRNPH2 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
KEGG Pathways 2026 pathways involving RPL36A-HNRNPH2 protein from the KEGG Pathways 2026 dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of RPL36A-HNRNPH2 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of RPL36A-HNRNPH2 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles cell lines with RPL36A-HNRNPH2 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of RPL36A-HNRNPH2 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles drug perturbations changing expression of RPL36A-HNRNPH2 gene from the NIBR DRUG-seq U2OS MoA Box dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of RPL36A-HNRNPH2 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at RPL36A-HNRNPH2 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of RPL36A-HNRNPH2 gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of RPL36A-HNRNPH2 gene from the RummaGEO Gene Perturbation Signatures dataset.
Tabula Sapiens Gene-Cell Associations cell types with high or low expression of RPL36A-HNRNPH2 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset.
TargetScan Predicted Conserved microRNA Targets microRNAs regulating expression of RPL36A-HNRNPH2 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset.
TargetScan Predicted Nonconserved microRNA Targets microRNAs regulating expression of RPL36A-HNRNPH2 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with RPL36A-HNRNPH2 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.
WikiPathways Pathways 2014 pathways involving RPL36A-HNRNPH2 protein from the Wikipathways Pathways 2014 dataset.