RPS27 Gene

HGNC Family	S ribosomal proteins (RPS)
Name	ribosomal protein S27
Description	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the S27e family of ribosomal proteins and component of the 40S subunit. The encoded protein contains a C4-type zinc finger domain that can bind to zinc and may bind to nucleic acid. Mutations in this gene have been identified in numerous melanoma patients and in at least one patient with Diamond-Blackfan anemia (DBA). Elevated expression of this gene has been observed in various human cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2018]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRPS27, also known as metallopanstimulin‐1 (MPS-1), is a multifunctional ribosomal protein that, beyond its canonical role in protein synthesis, participates in the regulation of cell cycle and stress response pathways. Notably, RPS27 is integrated into the p53–MDM2 axis, where it is transcriptionally repressed by p53 while its homolog RPS27L is induced by p53, and both proteins interact with MDM2 to modulate p53 ubiquitination and stability. This reciprocal regulation underscores the protein’s essential function in maintaining genomic integrity and its evolutionary conservation as a key player in growth regulation and cellular stress responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMutations and aberrant regulation of RPS27 have been implicated in a range of human diseases, including various cancer types and congenital disorders. For example, frameshift and splicing mutations in RPS27 have been identified in patients with Diamond–Blackfan anemia, while recurrent mutations in the 5′ untranslated region of RPS27 have been discovered in approximately 10% of melanoma cases, potentially altering the regulation of its expression. In other malignancies, such as gastric, colorectal, and thyroid cancers, deregulated RPS27 expression has been linked to alterations in pathways that control apoptosis, proliferation, and invasiveness. Together, these findings suggest that both structural mutations and misexpression of RPS27 contribute to oncogenic processes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to transcriptional regulation, RPS27 is subject to critical post‐translational modifications that modulate its stability and function. Neddylation by MDM2, for instance, stabilizes RPS27 and its homolog RPS27L, thereby promoting cell survival in cancer models, while altered intracellular ion concentrations (as seen in cystic fibrosis models) modulate RPS27 expression, suggesting it can also function as a signaling effector. Moreover, studies in head and neck squamous cell carcinoma have shown that overexpression of RPS27 can inhibit tumor growth via cell cycle arrest and changes in focal adhesion dynamics, and yet its expression in normal tissues such as the adult cerebellum remains to be fully characterized. Collectively, these observations emphasize the multifaceted roles of RPS27—from ribosome biogenesis to tumorigenesis—and reveal its potential as a prognostic marker and therapeutic target."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "X Xiong, Y Zhao, H He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ribosomal protein S27-like and S27 interplay with p53-MDM2 axis as a target, a substrate and a regulator."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2010.569"}], "href": "https://doi.org/10.1038/onc.2010.569"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21170087"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21170087"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "J Alberto Fernandez-Pol "}, {"type": "b", "children": [{"type": "t", "text": "Conservation of multifunctional ribosomal protein metallopanstimulin-1 (RPS27) through complex evolution demonstrates its key role in growth regulation in Archaea, eukaryotic cells, DNA repair, translation and viral replication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Genomics Proteomics (2011)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21518817"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21518817"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "J Alberto Fernandez-Pol "}, {"type": "b", "children": [{"type": "t", "text": "Increased serum level of RPMPS-1/S27 protein in patients with various types of cancer is useful for the early detection, prevention and therapy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Genomics Proteomics (2012)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22798506"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22798506"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "RuNan Wang, Kenichi Yoshida, Tsutomu Toki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of function mutations in RPL27 and RPS27 identified by whole-exome sequencing in Diamond-Blackfan anaemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Haematol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/bjh.13229"}], "href": "https://doi.org/10.1111/bjh.13229"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25424902"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25424902"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ken Dutton-Regester, Jared J Gartner, Rafi Emmanuel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A highly recurrent RPS27 5'UTR mutation in melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.2048"}], "href": "https://doi.org/10.18632/oncotarget.2048"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24913145"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24913145"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Zhong-Yin Yang, Ying Qu, Qing Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of metallopanstimulin-1 inhibits NF-κB signaling at different levels: the role of apoptosis induction of gastric cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.26331"}], "href": "https://doi.org/10.1002/ijc.26331"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21796632"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21796632"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Dongxing Cao, Yang Luo, Shaolan Qin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Metallopanstimulin-1 (MPS-1) mediates the promotion effect of leptin on colorectal cancer through activation of JNK/c-Jun signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-019-1911-8"}], "href": "https://doi.org/10.1038/s41419-019-1911-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31506433"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31506433"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Alfredo Floristán, Leah Morales, Douglas Hanniford, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional analysis of RPS27 mutations and expression in melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pigment Cell Melanoma Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/pcmr.12841"}], "href": "https://doi.org/10.1111/pcmr.12841"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31663663"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31663663"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jing Wan, Juan Lv, Chun Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RPS27 selectively regulates the expression and alternative splicing of inflammatory and immune response genes in thyroid cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Adv Clin Exp Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.17219/acem/147271"}], "href": "https://doi.org/10.17219/acem/147271"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35546566"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35546566"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yuemeng Dai, Spencer E Pierson, W Cross Dudney, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Extraribosomal function of metallopanstimulin-1: reducing paxillin in head and neck squamous cell carcinoma and inhibiting tumor growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.24791"}], "href": "https://doi.org/10.1002/ijc.24791"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19642098"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19642098"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Ángel G Valdivieso, Consuelo Mori, Mariángeles Clauzure, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CFTR modulates RPS27 gene expression using chloride anion as signaling effector."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Biochem Biophys (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.abb.2017.09.014"}], "href": "https://doi.org/10.1016/j.abb.2017.09.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28941802"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28941802"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Xiufang Xiong, Danrui Cui, Yanli Bi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neddylation modification of ribosomal protein RPS27L or RPS27 by MDM2 or NEDP1 regulates cancer cell survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.202000530RRR"}], "href": "https://doi.org/10.1096/fj.202000530RRR"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32779270"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32779270"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "J Alberto Fernandez-Pol "}, {"type": "b", "children": [{"type": "t", "text": "A Novel Marker for Purkinje Cells, Ribosomal Protein MPS1/S27: Expression of MPS1 in Human Cerebellum."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Genomics Proteomics (2016)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26708598"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26708598"}]}]}]}
Synonyms	MPS-1, S27, DBA17
Proteins	RS27_HUMAN
NCBI Gene ID	6232
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

RPS27 has 14,810 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 116 datasets.

Click the + buttons to view associations for RPS27 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

RPS27 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RPS27 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of RPS27 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of RPS27 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of RPS27 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of RPS27 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of RPS27 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of RPS27 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of RPS27 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with RPS27 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RPS27 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of RPS27 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of RPS27 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RPS27 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing RPS27 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing RPS27 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with RPS27 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with RPS27 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing RPS27 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of RPS27 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with RPS27 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with RPS27 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with RPS27 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving RPS27 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with RPS27 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with RPS27 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with RPS27 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with RPS27 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with RPS27 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at RPS27 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of RPS27 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of RPS27 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing RPS27 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of RPS27 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with RPS27 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing RPS27 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of RPS27 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of RPS27 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of RPS27 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of RPS27 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	transcription factor perturbations changing expression of RPS27 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.