{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent large‐scale kinome analyses have broadened our understanding of the many protein kinases encoded in the human genome, and while the precise functions of several remain to be fully elucidated, emerging evidence suggests that less‐characterized kinases like RPS6KC1 may play important regulatory roles. In the seminal kinome cataloguing study, over 500 putative kinases were identified and novel family members were reported, raising the possibility that RPS6KC1 might similarly participate in critically regulated phosphorylation cascades. In related studies of cell fate, programmed cell death pathways—especially those mediated by receptor‐interacting protein kinases (RIP) such as RIP1 and RIP3—were shown to orchestrate necroptosis and modulate inflammatory signaling in response to cytokines (for example, TNF‑α) and pathogen challenge. These investigations, which also noted caspase‑independent, kinase‐dependent modes of cell death, offer a conceptual framework within which RPS6KC1 might, by analogy, contribute to similar signal transduction events."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistic studies of programmed necrosis (necroptosis) and related inflammatory cell death have detailed how phosphorylation events—often mediated by kinases in the RIP family—promote formation of multimolecular complexes (necrosomes) that activate downstream effectors such as MLKL, leading to plasma membrane permeabilization and release of pro‐inflammatory mediators. In parallel, investigations into caspase‑8, FADD and other signaling adaptors have demonstrated that regulated kinase activity is pivotal in steering cells between apoptosis and necroptosis, thereby calibrating immune responses and tissue homeostasis. Given these findings, it is plausible that RPS6KC1, as a member of the broader kinase network identified in these studies, might function by phosphorylating key substrates within similar regulatory complexes or by modulating stress/immunological signaling pathways. Although direct experimental evidence linking RPS6KC1 to any specific cell death or inflammatory cascade remains to be determined, such analogies to the well‐established roles of RIP1, RIP3, and their partners provide an attractive hypothesis for its potential involvement."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn summary, while RPS6KC1 has yet to be functionally characterized in its own right, its inclusion in comprehensive kinase inventories and its potential structural relationship to kinases that drive regulated necroptosis and inflammatory signaling suggest that it could act as a modulator of phosphorylation‐dependent pathways critical for cell survival, death, and immune regulation. Such a role would be analogous to the established functions of RIP1, RIP3, and related kinases that govern necroptosis and inflammation, pointing to the possibility of RPS6KC1 serving as a novel target for intervention in diseases where aberrant cell death and inflammatory responses are central. Future experimental studies are needed to clarify its substrates, interacting partners, and specific contributions to these complex cellular processes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "20", "end_ref": "27"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "G Manning, D B Whyte, R Martinez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The protein kinase complement of the human genome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1075762"}], "href": "https://doi.org/10.1126/science.1075762"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12471243"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12471243"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Duan-Wu Zhang, Jing Shao, Juan Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1172308"}], "href": "https://doi.org/10.1126/science.1172308"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19498109"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19498109"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Sudan He, Lai Wang, Lin Miao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2009.05.021"}], "href": "https://doi.org/10.1016/j.cell.2009.05.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19524512"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19524512"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Young Sik Cho, Sreerupa Challa, David Moquin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2009.05.037"}], "href": "https://doi.org/10.1016/j.cell.2009.05.037"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19524513"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19524513"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jason W Upton, William J Kaiser, Edward S Mocarski "}, {"type": "b", "children": [{"type": "t", "text": "Virus inhibition of RIP3-dependent necrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Host Microbe (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.chom.2010.03.006"}], "href": "https://doi.org/10.1016/j.chom.2010.03.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20413098"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20413098"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "George Trichonas, Yusuke Murakami, Aristomenis Thanos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Receptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1009179107"}], "href": "https://doi.org/10.1073/pnas.1009179107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21098270"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21098270"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "William J Kaiser, Jason W Upton, Alyssa B Long, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RIP3 mediates the embryonic lethality of caspase-8-deficient mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature09857"}], "href": "https://doi.org/10.1038/nature09857"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21368762"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21368762"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Andrew Oberst, Christopher P Dillon, Ricardo Weinlich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature09852"}], "href": "https://doi.org/10.1038/nature09852"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21368763"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21368763"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Patrick-Simon Welz, Andy Wullaert, Katerina Vlantis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature10273"}], "href": "https://doi.org/10.1038/nature10273"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21804564"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21804564"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Sudan He, Yuqiong Liang, Feng Shao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1116302108"}], "href": "https://doi.org/10.1073/pnas.1116302108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22123964"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22123964"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Linde Duprez, Nozomi Takahashi, Filip Van Hauwermeiren, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RIP kinase-dependent necrosis drives lethal systemic inflammatory response syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2011.09.020"}], "href": "https://doi.org/10.1016/j.immuni.2011.09.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22195746"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22195746"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "James E Vince, W Wei-Lynn Wong, Ian Gentle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2012.01.012"}], "href": "https://doi.org/10.1016/j.immuni.2012.01.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22365665"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22365665"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Jason W Upton, William J Kaiser, Edward S Mocarski "}, {"type": "b", "children": [{"type": "t", "text": "DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Host Microbe (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.chom.2012.01.016"}], "href": "https://doi.org/10.1016/j.chom.2012.01.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22423968"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22423968"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Lukas Bossaller, Ping-I Chiang, Christian Schmidt-Lauber, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cutting edge: FAS (CD95) mediates noncanonical IL-1β and IL-18 maturation via caspase-8 in an RIP3-independent manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1202121"}], "href": "https://doi.org/10.4049/jimmunol.1202121"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23144495"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23144495"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "William J Kaiser, Haripriya Sridharan, Chunzi Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.462341"}], "href": "https://doi.org/10.1074/jbc.M113.462341"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24019532"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24019532"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Kim Newton, Debra L Dugger, Katherine E Wickliffe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1249361"}], "href": "https://doi.org/10.1126/science.1249361"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24557836"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24557836"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Dan Weng, Robyn Marty-Roix, Sandhya Ganesan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1403477111"}], "href": "https://doi.org/10.1073/pnas.1403477111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24799678"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24799678"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Christopher P Dillon, Ricardo Weinlich, Diego A Rodriguez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2014.04.018"}], "href": "https://doi.org/10.1016/j.cell.2014.04.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24813850"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24813850"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "J-X Li, J-M Feng, Y Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The B-Raf(V600E) inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2014.241"}], "href": "https://doi.org/10.1038/cddis.2014.241"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24901049"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24901049"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Xing Wang, Yun Li, Shan Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Direct activation of RIP3/MLKL-dependent necrosis by herpes simplex virus 1 (HSV-1) protein ICP6 triggers host antiviral defense."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1412767111"}], "href": "https://doi.org/10.1073/pnas.1412767111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25316792"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25316792"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Xiaqiong Wang, Wei Jiang, Yiqing Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ni.3015"}], "href": "https://doi.org/10.1038/ni.3015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25326752"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25326752"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Zhe Huang, Su-Qin Wu, Yaoji Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RIP1/RIP3 binding to HSV-1 ICP6 initiates necroptosis to restrict virus propagation in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Host Microbe (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.chom.2015.01.002"}], "href": "https://doi.org/10.1016/j.chom.2015.01.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25674982"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25674982"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Michio Onizawa, Shigeru Oshima, Ulf Schulze-Topphoff, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ni.3172"}], "href": "https://doi.org/10.1038/ni.3172"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25939025"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25939025"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "John Silke, James A Rickard, Motti Gerlic "}, {"type": "b", "children": [{"type": "t", "text": "The diverse role of RIP kinases in necroptosis and inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ni.3206"}], "href": "https://doi.org/10.1038/ni.3206"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26086143"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26086143"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Ting Zhang, Yan Zhang, Mingyao Cui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress-induced myocardial necroptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.4017"}], "href": "https://doi.org/10.1038/nm.4017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26726877"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26726877"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Yingying Zhang, Sheng Sean Su, Shubo Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms14329"}], "href": "https://doi.org/10.1038/ncomms14329"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28176780"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28176780"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Hao Zhou, Pingjun Zhu, Jun Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ripk3 induces mitochondrial apoptosis via inhibition of FUNDC1 mitophagy in cardiac IR injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Redox Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.redox.2017.07.007"}], "href": "https://doi.org/10.1016/j.redox.2017.07.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28732308"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28732308"}]}]}]}